Effect of Oily Fish Intake, Sex, Age, BMI, and APOE Genotype on Plasma Long Chain n-3 Fatty Acid Composition
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|ClinicalTrials.gov Identifier: NCT03245749|
Recruitment Status : Completed
First Posted : August 10, 2017
Last Update Posted : August 14, 2017
|Condition or disease|
|Plasma Omega-3 Status|
The marine long chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are beneficial to cardiovascular and cognitive health and the concentration of EPA and DHA present in blood and tissue lipids is positively correlated with these effects.
As a result, national and global authorities recommend regular consumption of oily fish in order to provide approximately 500 mg EPA+DHA per day in a healthy population. However, the associations between EPA and DHA intake and blood and tissue status, and therefore physiological benefits, are highly variable and the factors influencing this heterogeneity are not well understood.
This study aims to investigate the effect of habitual oily fish intake as well as sex, age, BMI, and Apolipoprotein E (APOE) genotype on LC n-3 PUFA status in plasma phosphatidylcholine, non-esterified fatty acids, cholesteryl esters and triacylglycerols in order to obtain greater knowledge of the determinants of LC n-3 PUFA status with the potential to develop more robust, and perhaps subgroup specific, recommendations for EPA and DHA intake.
|Study Type :||Observational|
|Actual Enrollment :||374 participants|
|Official Title:||Effect of Oily Fish Intake, Sex, Age, BMI, and APOE Genotype on Plasma Long Chain n-3 Fatty Acid Composition|
|Actual Study Start Date :||June 2003|
|Actual Primary Completion Date :||September 2005|
|Actual Study Completion Date :||March 2006|
- Plasma long chain n-3 polyunsaturated fatty acid concentrations [ Time Frame: Baseline ]Concentrations of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) in plasma phosphatidylcholine, non-esterified fatty acids, cholesteryl esters and triacylglycerols
- APOE genotyping [ Time Frame: Baseline ]APOE genotype determined from blood sample
- Anthropometric measurements [ Time Frame: Baseline ]Height and weight to determine BMI
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03245749
|University of Glasgow|
|Glasgow, United Kingdom|
|Newcastle upon Tyne, United Kingdom|
|Univeristy of East Anglia|
|Norwich, United Kingdom|
|University of Reading|
|Reading, United Kingdom|
|University of Southampton|
|Southampton, United Kingdom|
|Principal Investigator:||Philip C Calder||University of Southampton|