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Canderel:Effects on Blood Glucose Concentration and Appetite Scores

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ClinicalTrials.gov Identifier: NCT03232008
Recruitment Status : Recruiting
First Posted : July 27, 2017
Last Update Posted : July 27, 2017
Sponsor:
Information provided by (Responsible Party):
Dr Christopher Corpe, King's College London

Brief Summary:
This study investigates the effects of Canderel, an aspartame and acesulfame-k blend artificial sweetener powder, on post-postprandial blood glucose levels and appetite scores. Participants will be randomly given either the placebo drink (3g of maltodextrin dissolved in 250ml of water) or the Canderel drink (3g of Canderel dissolved in 250ml of water) alongside an isocaloric breakfast. Blood glucose measurements will be obtained through finger pricking and appetite will be measured using self-reported visual analog scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after breakfast.

Condition or disease Intervention/treatment Phase
Artificial Sweetener Effects on Blood Glucose and Appetite Appetitive Behavior Dietary Supplement: Canderel drink Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: The Effects of Canderel (Aspartame and Acesulfame-k Blend) on Blood Glucose Concentration and Appetite Scores in Humans: a Randomised Controlled Trial
Actual Study Start Date : September 1, 2015
Estimated Primary Completion Date : February 28, 2018
Estimated Study Completion Date : February 28, 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Blood Sugar
Drug Information available for: Aspartame

Arm Intervention/treatment
Experimental: Canderel
Canderel drink (3g in 250ml water)
Dietary Supplement: Canderel drink
1.4% aspartame and 0.95% acesulfame-k and 95% maltodextrin; 3g dissolved in 250ml of water

No Intervention: Control
3g of maltodextrin in 250 ml of water



Primary Outcome Measures :
  1. Change in Blood glucose [ Time Frame: 0-180min (Measured from baseline to 90min every 15min; 90-180min every 30min) ]
    Capillary blood obtained from fingerprick and measured using glucose monitor

  2. Change in Appetite [ Time Frame: 0-180min (Measured from baseline to 90min every 15min; 90-180min every 30min) ]
    Feelings of hunger, desire to eat, fullness and alertness measured using Visual Analog Scale (VAS)



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Ages Eligible for Study:   18 Years to 64 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Healthy male and female adults (18-64)

Exclusion Criteria:


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03232008


Contacts
Contact: Kirnjot Mehat 44 (0)20 7836 5454 ext 4247 kirnjot.mehat@kcl.ac.uk

Locations
United Kingdom
King's College London Recruiting
London, United Kingdom, SE1 9NH
Contact: Christopher P Corpe    +44 (0) 20 7848 4269    christopher.corpe@kcl.ac.uk   
Sponsors and Collaborators
King's College London
Investigators
Principal Investigator: Dr. Christopher Corpe King's College London

Responsible Party: Dr Christopher Corpe, Dr. Christopher Corpe, King's College London
ClinicalTrials.gov Identifier: NCT03232008     History of Changes
Other Study ID Numbers: KCLMScNutr2017
First Posted: July 27, 2017    Key Record Dates
Last Update Posted: July 27, 2017
Last Verified: July 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Product Manufactured in and Exported from the U.S.: No

Keywords provided by Dr Christopher Corpe, King's College London:
Blood glucose
Appetite