Diagnostic of Iron Deficiency by Means of Non Invasive Measurement of Zink Protoporphyrin IX (ZnPP)
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|ClinicalTrials.gov Identifier: NCT03231865|
Recruitment Status : Completed
First Posted : July 27, 2017
Last Update Posted : June 8, 2018
|Condition or disease||Intervention/treatment|
|Iron-deficiency||Diagnostic Test: Non-invasive measurement of ZincProtoporphyrin IX|
Zinc-protoporphyrin (ZnPP) will be measured by a fluorescence technique. Restricted wave light (407/425 nm) is used to detect ZnPP in the bloodstream non-invasively through the oral mucosa. The spectroscopic measurements are translated into a ZnPP value (mumol/mol heme).
The non-invasive measurement of ZnPP is validated and compared to optical measurement of ZnPP in whole blood and high performance liquid chromatography (HPLC) measurement of ZnPP in whole blood.
The ZnPP value is compared to other iron-deficiency parameters: Ferritin, Transferrin saturation and soluble Transferrin receptor.
|Study Type :||Observational|
|Actual Enrollment :||300 participants|
|Official Title:||Diagnostic of Iron Deficiency by Means of Non Invasive Measurement of Zink Protoporphyrin IX|
|Actual Study Start Date :||July 27, 2017|
|Actual Primary Completion Date :||February 26, 2018|
|Actual Study Completion Date :||May 31, 2018|
Patients present themselves before an operation to the Anesthesiologist. They are screened for study eligibility.
Diagnostic Test: Non-invasive measurement of ZincProtoporphyrin IX
Within 30 seconds, a measurement is performed on the lip of a patient to determine a ZincProtoporphyrin value
- Validation of the non-invasive ZincProtoporphyrinIX measurement [ Time Frame: Baseline ]The value is compared to optical measurement of ZincProtoporphyrin in whole blood; in addition the value is compared to HPLC measurement in whole blood
- Comparison of the ZincProtoporyphyrinIX value to other iron-deficiency parameters [ Time Frame: Baseline ]The value is compared to Ferritin, Transferrin saturation and soluble transferrin receptor
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03231865
|University Hospital Zurich|
|Zurich, Switzerland, 8091|
|Principal Investigator:||Philipp Stein, MD||Institute of Anesthesiology, University and University Hospital Zurich|