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Dynamic Hyperinflation In Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients

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ClinicalTrials.gov Identifier: NCT03230617
Recruitment Status : Not yet recruiting
First Posted : July 26, 2017
Last Update Posted : July 27, 2017
Sponsor:
Information provided by (Responsible Party):
Nisreen Mtk, Assiut University

Brief Summary:
Chronic obstructive pulmonary disease is a common respiratory condition that is characterized by inflammation of the large and small peripheral airways , the alveoli and adjacent capillary networks. Severe airflow obstruction that imposes a significant load on the respiratory system is a major manifestation of Chronic obstructive pulmonary disease. The reduced expiratory airflow also causes air trapping at the end of expiration , producing alveolar pressure that are higher than atmospheric pressure before the next breath. This condition is intrinsic positive end-expiratory pressure .

Condition or disease Intervention/treatment
Pulmonary Disease, Chronic Obstructive Device: Mechanical ventilator

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Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Other
Time Perspective: Cross-Sectional
Official Title: Evaluation Of Dynamic Hyperinflation In Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients
Estimated Study Start Date : September 1, 2017
Estimated Primary Completion Date : September 1, 2018
Estimated Study Completion Date : December 31, 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: COPD Lung Diseases

Group/Cohort Intervention/treatment
Intrinsic positive end expiratory pressure > 5
chronic obstructive pulmonary disease patient with intrinsic positive end expiratory pressure more than5
Device: Mechanical ventilator
Mechanical ventilation, in the healthcare setting or home, helps patients breathe by assisting the inhalation of oxygen into the lungs and the exhalation of carbon dioxide. Depending on the patient's condition, mechanical ventilation can help support or completely control breathing.

Auto positive end expiratory pressure < 5
chronic obstructive pulmonary disease patient with intrinsic positive end expiratory pressure less than5
Device: Mechanical ventilator
Mechanical ventilation, in the healthcare setting or home, helps patients breathe by assisting the inhalation of oxygen into the lungs and the exhalation of carbon dioxide. Depending on the patient's condition, mechanical ventilation can help support or completely control breathing.




Primary Outcome Measures :
  1. The duration of mechanical ventilation [ Time Frame: 1 month ]


Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
All patient who diagnosed as chronic obstructive pulmonary disease admitted to the respiratory intensive care unit, chest department, Assiut university hospital, who are mechanically ventilated.
Criteria

Inclusion Criteria:

  • patient with acute exacerbation of Chronic obstructive pulmonary disease and respiratory failure who are intubated and mechanically ventilated.

Exclusion Criteria:

  • patient with neuromuscular diseases.
  • patient with pulmonary vascular diseases e.g pulmonary embolism.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03230617


Contacts
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Contact: Suzan Salama, MSc 0101423616 Suzansalama61@yahoo.com
Contact: Aliae Abd Rabou, MD 01222302352 aliaehussein@Gmail.com

Locations
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Egypt
Assiut University Not yet recruiting
Assiut, Egypt
Contact: Nisreen Marghany Taha, MD    01019293548    Nisreen.new@Gmail.com   
Sponsors and Collaborators
Assiut University

Publications:
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Responsible Party: Nisreen Mtk, principal investigator, Assiut University
ClinicalTrials.gov Identifier: NCT03230617     History of Changes
Other Study ID Numbers: EDHMVCP
First Posted: July 26, 2017    Key Record Dates
Last Update Posted: July 27, 2017
Last Verified: July 2017

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
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Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Chronic Disease
Respiratory Tract Diseases
Disease Attributes
Pathologic Processes