Effects of Polyphenols Supplementation on Cycling Endurance
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03214276|
Recruitment Status : Completed
First Posted : July 11, 2017
Last Update Posted : July 11, 2017
Endurance performance during high intensive exercises is mainly determined by the capacity of the aerobic metabolism. It generally induces muscle fatigue defined as the reversible decline in skeletal muscle contractile performance. Fatigue is multifactorial and is often associated with many physiological parameters including reduced neural input and disruptive metabolic changes in skeletal muscles such as lactic acidosis and the production of oxidative free radicals. Moreover, it could lead to oxidative stress as a result of an imbalance between reactive oxygen species (ROS) production and intrinsic antioxidant defense.
To alleviate oxidative stress, some ergogenic strategies have been tested. Numerous studies have reported that different types of supplementation such as selenium, vitamin E, vitamin C or polyphenols were of interest to protect against these mechanisms. Indeed, although some studies demonstrated no or harmful effects, most studies observed positive effects of antioxidants on oxidative stress or performance. More particularly, polyphenols, have great antioxidant capabilities and protective effects and it increases the synthesis and bioavailability of nitric oxide (NO)which is well known to be the most important mediator of vasodilation. To date, most of the studies exploring the effects of polyphenols on exercise investigated several days or weeks of supplementations on vascular, blood parameters (blood pressure, NO concentration, oxidative stress markers) or endurance performance. Conflicting results are often obtained. Only few studies investigated the effects of a single intake on immediate performance and recovery capacity. Therefore, the present work aimed to study the effects of an acute intake of a specific profile polyphenols from grape and apple on physical performances. More specifically, performance, in the present study, referred to high intensity cycling exercise until exhaustion revealing the capacity to maintain a constant strong effort hereafter named endurance. The hypothesis was that an acute of polyphenols would increase the time to exhaustion during a high intensity cycling exercise.
|Condition or disease||Intervention/treatment||Phase|
|Healthy||Dietary Supplement: Vinitrox polyphenols Dietary Supplement: Placebo||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||48 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Triple (Participant, Investigator, Outcomes Assessor)|
|Primary Purpose:||Basic Science|
|Official Title:||Effects of Acute Specific Grape and Apple Polyphenols Supplementation on Cycling Endurance Performance|
|Actual Study Start Date :||January 1, 2012|
|Actual Primary Completion Date :||June 1, 2012|
|Actual Study Completion Date :||July 1, 2012|
Active Comparator: Polyphenols
The preceding night and one hour before the endurance test, participants were asked to absorb two capsules of 250 mg of polyphenols (Vinitrox™)
Dietary Supplement: Vinitrox polyphenols
Vinitrox™ (Nexira - France) is a combination of specific profile polyphenols from grape and apple. The main polyphenol classes are proanthocyanidins (as catechins, B2 dimer), phenolic acids (as chlorogenic acids, gallic acids) and anthocyanins (as malvidin-3-glucoside). It was administrated the night and the morning before the endurance test (oral administration)
Placebo Comparator: placebo
The preceding night and one hour before the endurance test, participants were asked to absorb two capsules of placebo (similar appearance and flavour than active comparator).
Dietary Supplement: Placebo
Made with maltodextrin. It was administrated the night and the morning before the endurance test (oral administration).
- Time to exhaustion [ Time Frame: The total duration of the aerobic exercise (during the cycling aerobic exercise) ]Maximal duration during a cycling aerobic exercise (70% of maximal aerobic power)
- Heart rate [ Time Frame: Immediately before the endurance test, immediately after the endurance test and continuously recorded during three minutes during the recovery to determine half-recovery time ]Heart rate using a polar belt
- Gaz exchange [ Time Frame: Immediately before the endurance test, immediately after the endurance test and continuously recorded during three minutes during the recovery to determine half-recovery time ]oxygen intake using a portable gaz exchange analyzer
- blood pressure [ Time Frame: Immediately before the endurance test, immediately after the endurance test ]blood pressure measured at the arm
- Pain sensation [ Time Frame: Immediately after the endurance exercise and 48 hours after the endurance test ]Pain sensation using a visual analog scale
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03214276
|Principal Investigator:||Nicolas Babault, PhD||University of Burgundy|