Study of the Prognosis of Infectious Endocarditis (EPEI) (EPEI)
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|ClinicalTrials.gov Identifier: NCT03211975|
Recruitment Status : Recruiting
First Posted : July 11, 2017
Last Update Posted : September 13, 2018
Infectious endocarditis (IE) is the localization and proliferation of blood-borne germs in the endocardium. It remains a complicated disease to manage due to its low incidence, diagnostic difficulties, the change in epidemiology in recent decades and high mortality rates. The annual incidence is estimated at 3-10 cases per 100,000 people.
The epidemiology of AR has changed significantly in recent years due to new risk factors. Indeed, the frequency of rheumatic heart disease, which was the first predisposing factor, decreased markedly in the industrialized countries, replaced by new predisposing factors: the presence of valvular prostheses or intracardiac materials (the risk of AR is multiplied by 50 Compared with the general population), hemodialysis, nosocomial infections, immunosuppression, increased use of injectable treatments and, above all, an aging population with an increase in degenerative diseases such as aortic stenosis and l Mitral insufficiency.
The diagnosis of IA is based on DUKE criteria. But the clinical presentation is sometimes atypical especially in case of infection on prosthesis where the diagnosis is based mainly on the results of the blood cultures and the ultrasound data.
The lesions visualized in ultrasound are: vegetations, abscesses, pseudo-aneurysms and fistulas constituting the degenerated abscess evolution, the perforation of the cusps of the native valve or the bioprosthesis giving rise to a jet of Eccentric regurgitation.
The evolution of endocarditis and its prognosis vary according to many factors: the type of germ responsible, the precocity of the diagnosis, the existence of a complication, the site of occurrence. These complications of endocarditis are frequent, sometimes revealing. EI is complicated by heart failure, atrioventricular conduction disorders, peri-vascular abscesses, embolic, neurological, renal and septic complications. Despite improvements in diagnosis and therapeutic methods, diagnosis is sometimes difficult, management remains very complicated and morbidity and mortality remain high. Studies are still needed to study the prognosis and to determine the predictive factors for hospital mortality and long-term mortality.
|Condition or disease||Intervention/treatment|
|Endocarditis Infective||Other: To study the evolution of the prognosis of infectious endocarditis on native valves and on prostheses|
|Study Type :||Observational|
|Estimated Enrollment :||645 participants|
|Official Title:||Study of the Prognosis of Infectious Endocarditis (EPEI): Prospective and Retrospective Follow-up of a Cohort of Patients Hospitalized for Infectious Endocarditis|
|Actual Study Start Date :||February 27, 2017|
|Estimated Primary Completion Date :||February 25, 2032|
|Estimated Study Completion Date :||February 25, 2032|
- Other: To study the evolution of the prognosis of infectious endocarditis on native valves and on prostheses
To study the evolution of the prognosis of infectious endocarditis on native valves and on prostheses
- Analysis of hospital mortality and long-term overall mortality. [ Time Frame: 1 day ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03211975
|Contact: Christophe TRIBOUILLOY, PhDfirstname.lastname@example.org|
|CHU Amiens Picardie||Recruiting|
|Amiens, Picardie, France, 80054|
|Contact: Christophe TRIBOUILLOY, PhD +33322455885 email@example.com|