Interrelation Between Bronchial Asthma and Smoking
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03207620|
Recruitment Status : Recruiting
First Posted : July 5, 2017
Last Update Posted : January 15, 2019
|Condition or disease|
The mechanisms by which cigarette smoking contributes to disease severity in asthma are incompletely understood, but it has been suggested that cigarette smoking may change inflammation and airway remodelling in asthma to become more similar to that in COPD (chronic obstructive pulmonary disease).
Any form of tobacco use, especially cigarette smoking, plays an important role in this disease. Asthmatic smokers are prone to several negative outcomes. Cigarette smoking by itself is associated with airway inflammation and features of airway remodelling including increased epithelial proliferation, squamous cell metaplasia, goblet cell hyperplasia, smooth muscle hypertrophy, and increases in bronchial glands mass.
Corticosteroid insensitivity is an important clinical feature of asthma, particularly in patients with severe disease and smokers. The mechanisms of corticosteroid insensitivity in asthmatic patients are poorly understood.
One of the major problems in the treatment of smoking asthma patients is the lack of efficacy data in this group of patients as smokers have almost always been excluded from studies on asthma due to perceived concerns about recruiting patients with COPD. Therefore, there is a lack of specific information about the treatment of asthma in smokers. The asthmatic smoker is a special phenotype with important therapeutic and prognostic clinical implications.
|Study Type :||Observational|
|Estimated Enrollment :||104 participants|
|Official Title:||Interrelation Between Bronchial Asthma and Smoking|
|Actual Study Start Date :||August 9, 2018|
|Estimated Primary Completion Date :||August 1, 2019|
|Estimated Study Completion Date :||February 1, 2020|
- serum periostin [ Time Frame: one day ]detect its level in serum
- Serum eotaxin [ Time Frame: One day ]detect its level in serum
- Spirometry [ Time Frame: one day ]pre- and post bronchodilator FEV1 will be measured.
- Sputum cytology [ Time Frame: one day ]detect proportion of eosinophils and neutrophils in sputum cytology.
- airway corticosteroid sensitivity [ Time Frame: one month ]Airway corticosteroid sensitivity will be assessed by change in pre-bronchodilator FEV1 (forced expiratory volume at one second) .
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03207620
|Contact: Atef F Al-karn, MDemail@example.com|
|Contact: Mohamed F Abd El-Ghany, MDfirstname.lastname@example.org|
|Assuit University Hospital||Recruiting|
|Assiut, Egypt, Assiut university 71515|
|Contact: Safaa A Eid, master 01002569966 email@example.com|
|Contact: Atef F Al-karn, MD 01006474200 firstname.lastname@example.org|
|Principal Investigator:||Safaa A Eid, master||Assiut University|