Expanded Access to Provide Loxo-195 for the Treatment of Cancers With a NTRK Gene Fusion
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Loxo-195 expanded access is for minor and adult patients with cancer having a change in a particular gene (NTRK1, NTRK2, or NTRK3 gene fusion). The patients are ineligible for an ongoing Loxo-195 clinical trial or have other considerations that prevent access to Loxo-195 through an existing clinical trial. Expanded access is intended to treat individual patients with different types of cancers with a NTRK gene fusion, including blood cancers, who have previously received tropomyosin receptor kinase (TRK) inhibitor therapy.
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Layout table for eligibility information
Ages Eligible for Study:
1 Month and older (Child, Adult, Older Adult)
Sexes Eligible for Study:
Diagnosis of cancer with a NTRK1, NTRK2, and NTRK3 gene fusion
Previous treatment with a kinase inhibitor with known activity on TRK inhibition
Unable to participate in an ongoing Loxo-195 clinical trial
Medically suitable for treatment with Loxo-195
Currently enrolled in an ongoing clinical study with a TRK inhibitor