Assessment of Severity and Outcome of Addicted Cases.
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|ClinicalTrials.gov Identifier: NCT03206411|
Recruitment Status : Recruiting
First Posted : July 2, 2017
Last Update Posted : July 2, 2017
- Addiction to drugs and alcohol is increasingly becoming a worldwide trend that is prevalent in both rich and poor countries . Substance abuse shows a significant warming to the health, social and economic build of families, communities and nations. Extent of worldwide psychoactive substance use is estimated at 2 billion alcohol users and 185 million drug users .
- Substance abuse (including alcohol and drugs) is an important risk factor for poor health globally due to their intoxicating effects or their toxic effects on organs and tissues that lead to the development of diseases, injuries and other health conditions
- Drug abuse is associated with the increased risk of cardiovascular diseases. A study on the need for hospitalization in approximately 4800 drug users found that 223 of these were admitted to hospital due to cardiovascular diseases .
- The majority of abused substances or their metabolites are excreted through the kidneys and renal complications of drug abuse are very common .The involvement of the kidney due to drug abuse is either attributed to their elimination through the kidney, or a direct nephrotoxic effect. The damage may be acute and reversible, or chronic and can leads to end stage renal failure .
- Addiction is responsible for different types of liver diseases including fatty liver, hepatitis and liver failure. . Intravenous drug addiction by sharing of contaminated needle is very important risk factor for the development of liver diseases, particularly hepatitis B and hepatitis C. Globally, 90% of new hepatitis C infections are attributed to drug injection . In the long run, substance abuse has negative effects on sexual functions and leads to the onset of sexual disorders. .
- Long term use of alcohol was reported to inhibit of hypothalamic-pituitary-adrenal axis and reduces the release of gonadotropins from the pituitary . Morphine administration suppresses LH release and reduces the levels of testosterone, which affects testicular function.
|Condition or disease||Intervention/treatment|
|Addiction, Substance||Diagnostic Test: Renal and liver function tests , ECG , Sex Hormones Profile|
|Study Type :||Observational|
|Estimated Enrollment :||80 participants|
|Official Title:||Assessment of Severity and Outcome of Addicted Cases Admitted to Neurology and Psychiatry Hospital in Assiut University.|
|Actual Study Start Date :||December 1, 2016|
|Estimated Primary Completion Date :||November 30, 2017|
|Estimated Study Completion Date :||November 30, 2018|
- Diagnostic Test: Renal and liver function tests , ECG , Sex Hormones Profile
Renal Function tests as creatinine , Uric Acid , Blood urea. Liver Function tests as AST , ALT, ALP ECG (Electrocardiogram recording) SEX hormones as LH , FSH , and Testosterone
- Sex Hormones Profile [ Time Frame: 1 day ]Measure the changes in the Sex Hormones (LH , FSH and Testosterone) due to drug addiction in different people.
- Liver Function tests. [ Time Frame: 1 day ]Measure the changes in the liver enzymes (AST,ALT and ALP) due to drug addiction in different people.
- Renal Functions tests. [ Time Frame: 1 day ]Measure the changes in the renal function due to drug addiction in different people.
- ECG [ Time Frame: 1 day ]Record the changes in the Electrocradiogram due to addiction
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03206411
|Contact: Sarah A. Mohammed||0201062031286||Sara_abdelsamee@yahoo.com|