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Clinical Subgroups in Patellofemoral Pain Syndrome

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ClinicalTrials.gov Identifier: NCT03201133
Recruitment Status : Completed
First Posted : June 28, 2017
Last Update Posted : April 18, 2019
Sponsor:
Information provided by (Responsible Party):
Marco Aurélio Vaz, PhD, Federal University of Rio Grande do Sul

Brief Summary:
Patellofemoral pain syndrome (PFPS) is a multifactorial pathology characterized by diffuse retropatellar and peripatellar pain in the knee joint, exacerbated by overloading activities on the patellofemoral joint. However, this disease showed high degree of patients not responsive to therapeutic strategies. This condition occurred because several factors is related to disease such as: (1) proximal factors (involving trunk and hip), (2) local factors (surrounding and or within the patellofemoral joint) and (3) distal factors (involving ankle and foot). Thus, the identification of clinical subgroups based in anatomic changes (proximal, local and distal factors) is a recent strategy that could help in the therapeutic strategies focused on the etiology of the disease, improve responsiveness to treatment, clinical and functional benefits.

Condition or disease Intervention/treatment
Patellofemoral Pain Syndrome Diagnostic Test: Neuromuscular evaluation

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Study Type : Observational
Actual Enrollment : 45 participants
Observational Model: Case-Control
Time Perspective: Retrospective
Official Title: Clinical Subgroups Identification in Patellofemoral Pain Syndrome Patients
Actual Study Start Date : September 1, 2017
Actual Primary Completion Date : October 25, 2017
Actual Study Completion Date : December 1, 2018

Group/Cohort Intervention/treatment
Patellofemoral pain syndrome with changes in proximal factors Diagnostic Test: Neuromuscular evaluation
(1) Muscle trunk endurance test; (2) Hip isometric strength (abductor, lateral rotation, extension); (3) Knee extensor isometric strength; (4) unilateral squat; (5) navicular drop test; (6) muscle architecture at rest of gluteus medius, gluteus maximus,vastus lateralis, vastus medialis and rectus femoris; (7) muscle activation during unilateral squat (gluteus and quadriceps muscles); (8) pennation angle of obliques vastus medialis; (9) medial patellofemoral ligament length; (10) knee pain.

Patellofemoral pain syndrome with changes in local factors Diagnostic Test: Neuromuscular evaluation
(1) Muscle trunk endurance test; (2) Hip isometric strength (abductor, lateral rotation, extension); (3) Knee extensor isometric strength; (4) unilateral squat; (5) navicular drop test; (6) muscle architecture at rest of gluteus medius, gluteus maximus,vastus lateralis, vastus medialis and rectus femoris; (7) muscle activation during unilateral squat (gluteus and quadriceps muscles); (8) pennation angle of obliques vastus medialis; (9) medial patellofemoral ligament length; (10) knee pain.

Patellofemoral pain syndrome with changes in distal factors Diagnostic Test: Neuromuscular evaluation
(1) Muscle trunk endurance test; (2) Hip isometric strength (abductor, lateral rotation, extension); (3) Knee extensor isometric strength; (4) unilateral squat; (5) navicular drop test; (6) muscle architecture at rest of gluteus medius, gluteus maximus,vastus lateralis, vastus medialis and rectus femoris; (7) muscle activation during unilateral squat (gluteus and quadriceps muscles); (8) pennation angle of obliques vastus medialis; (9) medial patellofemoral ligament length; (10) knee pain.




Primary Outcome Measures :
  1. Muscular strength tests of hip and knee muscles. [ Time Frame: 1 day ]
    Isometric torque of knee extensor muscles, hip abductor, extension and medial rotation muscles through hand-held dynamometer tests will be performed to create clinical subgroups after cluster analysis for a focused intervention in the second step.

  2. Muscle thickness measures [ Time Frame: 1 day ]
    Muscle thickness (in millimeters) of vastus lateralis, vastus medialis and rectus femoris muscle. Muscle thickness of gluteus medius, maximus and peroneus muscle through ultrasound equipment. Tests Test will be performed to create clinical subgroups after cluster analysis for a focused intervention in the second step.

  3. Muscle activation of knee, hip and foot muscles [ Time Frame: 1 day ]
    Muscle activation measures of quadriceps, gluteus maximus, gluteus medius and peroneus muscles during unilateral squat through surface electromyography. Tests will be performed to create clinical subgroups after cluster analysis for a focused intervention in the second step.

  4. Kinematics during unilateral squat [ Time Frame: 1 day ]
    Pelvis, hip, knee and ankle angular displacement during unilateral squat through kinematics analysis. Tests will be performed to create clinical subgroups after cluster analysis for a focused intervention in the second step.

  5. Fascicle length measures [ Time Frame: 1 day ]
    Fascicle length (in milimeters) of vastus lateralis, vastus medialis and rectus femoris muscle through ultrasound equipment. Tests Test will be performed to create clinical subgroups after cluster analysis for a focused intervention in the second step.

  6. Pennation angle measures [ Time Frame: 1 day ]
    Pennation angle (in °) of vastus lateralis, vastus medialis and rectus femoris muscle through ultrasound equipment. Tests Test will be performed to create clinical subgroups after cluster analysis for a focused intervention in the second step.



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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Female
Sampling Method:   Non-Probability Sample
Study Population
Patellofemoral pain syndrome women
Criteria

Inclusion Criteria:

  • Peripatellar or retropatellar pain in at least two of the following situations: squatting, running, kneeling, jumping, climbing or descending stairs and sitting for a prolonged period of time for at least three months.

Exclusion Criteria:

  • Engaged in systematic exercise with focus on lower limb in the last six months and Had an injury to the hip and ankle joint in the last 12 months.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03201133


Locations
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Brazil
Exercise Research Laboratory
Pôrto Alegre, Rio Grande Do Sul, Brazil, 90690200
Sponsors and Collaborators
Federal University of Rio Grande do Sul

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Responsible Party: Marco Aurélio Vaz, PhD, PhD, Federal University of Rio Grande do Sul
ClinicalTrials.gov Identifier: NCT03201133     History of Changes
Other Study ID Numbers: UFRGS 1.978.838
First Posted: June 28, 2017    Key Record Dates
Last Update Posted: April 18, 2019
Last Verified: April 2019

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
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Syndrome
Somatoform Disorders
Patellofemoral Pain Syndrome
Disease
Pathologic Processes
Mental Disorders
Joint Diseases
Musculoskeletal Diseases