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HFCS, Apple Juice, Excess Free Fructose & asthma-the FHS-OS

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT03189251
Recruitment Status : Completed
First Posted : June 16, 2017
Last Update Posted : June 16, 2017
Jaime Uribarri, M.D.
Katherine L. Tucker, Ph.D.
Information provided by (Responsible Party):
Luanne R DeChristopher, DeChristopher, Luanne R.

Brief Summary:
Perform an exploratory analysis of association between consumption of high excess free fructose (EFF) beverages (high fructose corn syrup sweetened soft drinks, fruit drinks, apple juice) and Chronic Bronchitis (CB)/history of CB, and asthma/ history of asthma.

Condition or disease Intervention/treatment
Asthma Other: Dietary intakes

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Study Type : Observational
Actual Enrollment : 2657 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Moderate Intake of High Fructose Corn Syrup Sweetened Soft Drinks, Fruit Drinks and Apple Juice Increases Asthma Risk - the Framingham Offspring Cohort
Actual Study Start Date : June 1971
Actual Primary Completion Date : June 2001

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Asthma
Drug Information available for: Fructose

Intervention Details:
  • Other: Dietary intakes
    Analysis of association between consumption of high excess free fructose (EFF) beverages (high fructose corn syrup sweetened soft drinks, fruit drinks, apple juice)

Primary Outcome Measures :
  1. Asthma [ Time Frame: Exams 3 - 7, 17 years of follow-up ]
    Incident asthma defined as self-reported asthma (at each exam), including wheezing or asthma (have you had asthma/ wheeze since the last exam of short duration, long duration or with respiratory infections)

Information from the National Library of Medicine

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Ages Eligible for Study:   5 Years to 70 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Participants in the Framingham Heart Study (Offspring) cohort

Inclusion Criteria:

  • Participants in the FHS Offspring who answered questions in the FFQ about soft drinks, fruit drinks and fruit juice consumption; Participants with non-missing data for the exposures and potentially confounding variables of interest.

Exclusion Criteria:

  • Extreme energy intake on food frequency questionnaire (defined as ≤600 kcal/day or ≥4800 kcal/day)

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Responsible Party: Luanne R DeChristopher, Independent Researcher, DeChristopher, Luanne R. Identifier: NCT03189251    
Other Study ID Numbers: EFF, HFCS, asthma-the FHS-OS
First Posted: June 16, 2017    Key Record Dates
Last Update Posted: June 16, 2017
Last Verified: June 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases