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Effect of Grape Juice Consumption on the Parameters of Oxidative Stress and Muscle Fatigue in Judo Athletes

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ClinicalTrials.gov Identifier: NCT03186573
Recruitment Status : Completed
First Posted : June 14, 2017
Last Update Posted : January 26, 2018
Sponsor:
Information provided by (Responsible Party):
Maria Júlia Vieira da Cunha Goulart, Federal University of Health Science of Porto Alegre

Brief Summary:
This project aims to evaluate if after 14 days of grape juice ingestion there is improvement of the parameters of strength, fatigue and oxidative stress in judo fighters. The study will be a randomized, blind, crossover clinical trial of 20 Judo athletes. Judo wrestling simulations will be performed on 3 different days.

Condition or disease Intervention/treatment Phase
Oxidative Stress Muscle Fatigue Polyphenol Free Radical Oxidation of Tissue Dietary Supplement: Grape juice Dietary Supplement: Maltodextrin Not Applicable

Detailed Description:
Grape juice has a high concentration of phenolic compounds and is capable of modulating biochemical parameters and oxidative stress. By naturally containing carbohydrates grape juice can help acutely minimize fatigue during exercise as well as long-term oxidative stress parameters in athletes. This project aims to evaluate if after 14 days of grape juice ingestion there is improvement of the parameters of strength, fatigue and oxidative stress in judo fighters. The study will be a randomized, blind, crossover clinical trial of 20 Judo athletes. Judo wrestling simulations will be performed on 3 different days. Each exercise session will consist of four 7-minute bouts, with 14-minute rest between them. The athletes will perform a first fight simulation without ingestion of any beverage (control group 1), and then will be randomized to determine the order of participation in the groups: maltodextrin (group 2 placebo) and grape juice (intervention group 3). Analyzes of oxidative stress; Muscle strength and fatigue; Perceived effort rate; Lactate; Heart rate; Analysis of food consumption and body composition.Two-way ANOVA will be used to evaluate the relation of the intervention and physical exercise, besides parameters of strength and fatigue. The level of significance adopted will be 5% and for the analysis, the SPSS summer 23 statistical program will be used.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 12 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Intervention Model Description: Randomized clinical trial
Masking: Double (Participant, Investigator)
Masking Description: Double blind study
Primary Purpose: Prevention
Official Title: Effect of Grape Juice Consumption on the Parameters of Oxidative Stress and Muscle Fatigue in Judo Athletes: A Randomized Clinical Trial
Actual Study Start Date : May 11, 2017
Actual Primary Completion Date : June 22, 2017
Actual Study Completion Date : August 17, 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Fatigue

Arm Intervention/treatment
No Intervention: Control Group
The athletes will not receive any drink and will do the simulations of the fight.
Active Comparator: Intervention group
(Intervention, grape juice) - athletes will receive 400 ml per day of grape juice (containing 66g of carbohydrates) for 14 days and will do the fight simulations.
Dietary Supplement: Grape juice
400ml diary of grape juice

Placebo Comparator: Placebo Group
(Placebo, grape-flavored maltodextrin carbohydrate) - athletes will receive400ml of drink daily with 66g of maltodextrin for 14 days and will do the fight simulations; The amount of maltodextrin is equal to the amount of carbohydrate present in grape juice.
Dietary Supplement: Maltodextrin
400ml diary of maltodextrin




Primary Outcome Measures :
  1. Oxidative stress In Blood Collection [ Time Frame: 15 days ]
    A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage.


Secondary Outcome Measures :
  1. Borg in scale. [ Time Frame: 15 days ]
    Specific to muscle fatigue, a state arrived at through prolonged and strong contraction of a muscle. Studies in athletes during prolonged submaximal exercise have shown that muscle fatigue increases in almost direct proportion to the rate of muscle glycogen depletion. Muscle fatigue in short-term maximal exercise is associated with oxygen lack and an increased level of blood and muscle lactic acid, and an accompanying increase in hydrogen-ion concentration in the exercised muscle.


Other Outcome Measures:
  1. Lactate in numbers [ Time Frame: 15 days ]
    Specific to muscle fatigue, a state arrived at through prolonged and strong contraction of a muscle. Studies in athletes during prolonged submaximal exercise have shown that muscle fatigue increases in almost direct proportion to the rate of muscle glycogen depletion. Muscle fatigue in short-term maximal exercise is associated with oxygen lack and an increased level of blood and muscle lactic acid, and an accompanying increase in hydrogen-ion concentration in the exercised muscle.

  2. Upper and lower limb strength in repetitions or numbers in meters [ Time Frame: 15 days ]
    Specific to muscle fatigue, a state arrived at through prolonged and strong contraction of a muscle. Studies in athletes during prolonged submaximal exercise have shown that muscle fatigue increases in almost direct proportion to the rate of muscle glycogen depletion. Muscle fatigue in short-term maximal exercise is associated with oxygen lack and an increased level of blood and muscle lactic acid, and an accompanying increase in hydrogen-ion concentration in the exercised muscle.

  3. Palmar grip strength - in strength and time [ Time Frame: 15 days ]
    Specific to muscle fatigue, a state arrived at through prolonged and strong contraction of a muscle. Studies in athletes during prolonged submaximal exercise have shown that muscle fatigue increases in almost direct proportion to the rate of muscle glycogen depletion. Muscle fatigue in short-term maximal exercise is associated with oxygen lack and an increased level of blood and muscle lactic acid, and an accompanying increase in hydrogen-ion concentration in the exercised muscle.

  4. muscle pain [ Time Frame: 15 days ]
    Specific to muscle fatigue, a state arrived at through prolonged and strong contraction of a muscle. Studies in athletes during prolonged submaximal exercise have shown that muscle fatigue increases in almost direct proportion to the rate of muscle glycogen depletion. Muscle fatigue in short-term maximal exercise is associated with oxygen lack and an increased level of blood and muscle lactic acid, and an accompanying increase in hydrogen-ion concentration in the exercised muscle.



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Ages Eligible for Study:   15 Years to 24 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Judo athletes, federated, who hold state, federal and international competitions of both sexes, aged between 15 and 24 years and any weight category of the sport, except free weight.

Exclusion Criteria:

  • Recent injury (last 3 months) that prevents training or competition;
  • Food restriction on grape juice;
  • Being in the phase of fast weight loss in pre competition..

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03186573


Locations
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Brazil
Cláudia Dornelles Schneider
Porto Alegre, Rio Grande Do Sul, Brazil
Sponsors and Collaborators
Federal University of Health Science of Porto Alegre
Investigators
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Principal Investigator: Cláudia Dornelles Schneider Federal University of Health Science of Porto Alegre
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Responsible Party: Maria Júlia Vieira da Cunha Goulart, Nutricionist, Federal University of Health Science of Porto Alegre
ClinicalTrials.gov Identifier: NCT03186573    
Other Study ID Numbers: UFCSPAPortoAlegre
First Posted: June 14, 2017    Key Record Dates
Last Update Posted: January 26, 2018
Last Verified: September 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Fatigue