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Does OCT Imaging Allow us to See Blood Vessel Development in and Around Deposits of Fat and Calcium Inside Blood Vessels

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ClinicalTrials.gov Identifier: NCT03182348
Recruitment Status : Recruiting
First Posted : June 9, 2017
Last Update Posted : January 30, 2020
Sponsor:
Information provided by (Responsible Party):
University of Leicester

Brief Summary:

Cardiovascular disease is the leading cause of illness and death in the world. The disease involves narrowing of blood vessels due to deposits of fat which can become coated in calcium. It is treated by percutaneous coronary intervention in which a balloon is passed down the blood vessel to remove the obstruction and where appropriate a stent is placed in the blood vessel to scaffold it.

Early stage research suggests that the growth of small blood vessels in and around the deposits of fat and calcium leads to the growth of the deposit and may contribute to plaque rupture into the vessel leading to clot formation the process which leads to heart attacks. Drugs which prevent the development of these small blood vessel restrict the development of the deposit, and those that encourage the development of these small blood vessel also increase the development of the deposit. Researchers would like to find out more about the system of blood vessels around deposits of fat and calcium in the larger blood vessels. This involves looking just beneath the surface of the blood vessel wall, and requires a detailed and accurate image. Researchers on this project would like to find out if optical coherence tomography (OCT) is a suitable technique for imaging in this way.

OCT works like an ultrasound, but using light instead of sound waves. The additional imaging will prolong the clinical procedure by 10-15 minutes.


Condition or disease Intervention/treatment
Cardiovascular Disease Procedure: Optical coherence tomography

Detailed Description:

Cardiovascular disease is the leading cause of illness and death in the world. Central to the process of this disease is the narrowing of blood vessels due to deposits of fatty residue which can become coated in calcium. Significant narrowing of the blood vessels is treated by percutaneous coronary intervention in which a balloon is inflated and passed down the blood vessel to remove the obstruction and where appropriate a stent is placed in the blood vessel to scaffold it.

Potential participants are those who have been scheduled for a percutaneous coronary intervention, are stable, and have a diagnosis of angina pectoris, unstable angina or acute coronary syndrome. These patients will be identified and screened by their healthcare team. Potential participants will be given study information by their healthcare team, or identified to the research team who will provide study information. The initial approach may be in clinic, in hospital, or by post.

Participants will be asked to give written informed consent to participate in the study. At the clinical pre-procedure visit consent is sought, exclusion and inclusion criteria checked.

Procedure: On the day of the patients procedure they will receive standard clinical care comprising angiography (imaging of the blood vessel), angioplasty (removal of fatty deposits with a balloon) and stenting. Before and after the procedure the patient will receive medication and after care as per standard clinical care. Those patients who are clinically indicated for stenting will undergo OCT imaging prior to the angioplasty and stenting.

The researchers need to allow flexibility in the process of acquiring the OCT images, so they can optimize the quality of the image. Therefore, the speed of pullback (removal of the catheter) and choice of blood clearing agents will not be pre-specified. Serial images of the same part of the vessel may be taken.

As part of the clinical angioplasty procedure the patient will have a coronary guidewire passed down the artery usually from the groin to the heart which is used to position balloons and stents. OCT passes over the wire in the same way. From the patients perspective the procedure may take a small amount of additional time - maximum 10-15 minutes. We would like to be able to pass a second wire down the same coronary artery called a 'buddy wire' which is sometimes required in coronary procedures. This would be used to inflate a balloon at low pressure near the area of interest in the heart in order either to exclude blood or to oppose the OCT catheter to the vessel wall if required.

If a patient returns for subsequent percutaneous coronary intervention they will be invited to participate again.

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Study Type : Observational
Estimated Enrollment : 30 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Coronary Optical Coherence Tomography Correlation and Strain Mapping to Investigate Human Atherosclerosis: a Feasibility Study
Actual Study Start Date : September 2012
Estimated Primary Completion Date : March 30, 2020
Estimated Study Completion Date : March 30, 2020

Group/Cohort Intervention/treatment
Optical coherence tomography
As part of the clinical angioplasty procedure the patient will have a coronary guidewire passed down the artery usually from the groin to the heart which is used to position balloons and stents. OCT passes over the wire in the same way. From the patients perspective the procedure may take a small amount of additional time - maximum 10-15 minutes. We would like to be able to pass a second wire down the same coronary artery called a 'buddy wire' which is sometimes required in coronary procedures. This would be used to inflate a balloon at low pressure near the area of interest in the heart in order either to exclude blood or to oppose the OCT catheter to the vessel wall if required.
Procedure: Optical coherence tomography
As part of the clinical angioplasty procedure the patient will have a coronary guidewire passed down the artery usually from the groin to the heart which is used to position balloons and stents. OCT passes over the wire in the same way. From the patients perspective the procedure may take a small amount of additional time - maximum 10-15 minutes. We would like to be able to pass a second wire down the same coronary artery called a 'buddy wire' which is sometimes required in coronary procedures. This would be used to inflate a balloon at low pressure near the area of interest in the heart in order either to exclude blood or to oppose the OCT catheter to the vessel wall if required.
Other Name: OCT




Primary Outcome Measures :
  1. Markers of high risk coronary diseases [ Time Frame: through study completion, an average of 1 year (Aprox March 2018) ]
    Novel OCT features as potential markers of high risk coronary diseases



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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients scheduled for elective percutaneous coronary intervention or coronary angiography with a view to coronary intervention on routine clinical criteria with diagnosis of angina pectoris, unstable angina or acute coronary syndrome with angiographically significant stenosis(es) (>70%) of one or more native coronary arteries.
Criteria

Inclusion Criteria:

  • Patients scheduled for elective percutaneous coronary intervention or coronary angiography with a view to coronary intervention on routine clinical criteria with diagnosis of angina pectoris, unstable angina or acute coronary syndrome with angiographically significant stenosis(es) (>70%) of one or more native coronary arteries.

Exclusion Criteria:

  • Primary angioplasty for S T -elevation myocardial infarction. Clinically unstable patients.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03182348


Contacts
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Contact: David Adlam, BA,BM,BCH,DPhil,MRCP 01162502480 da134@le.ac.uk

Locations
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United Kingdom
NIHR Cardiovascular BRU Recruiting
Leicester, Leicestershire, United Kingdom, LE3 9QP
Principal Investigator: David Adlam, BA, BM, BCH, DPhil, MRCP         
Sponsors and Collaborators
University of Leicester
Investigators
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Principal Investigator: David Adlam, BA,BM,BCH,DPhil,MRCP NIHR Leicester Cardiovascular BRU
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Responsible Party: University of Leicester
ClinicalTrials.gov Identifier: NCT03182348    
Other Study ID Numbers: 0255
First Posted: June 9, 2017    Key Record Dates
Last Update Posted: January 30, 2020
Last Verified: January 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by University of Leicester:
Microvessels
Cardiovascular disease
OCT
Additional relevant MeSH terms:
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Cardiovascular Diseases