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Trial record 19 of 100 for:    Recruiting, Not yet recruiting, Available Studies | "Bone Transplantation"

Concentrated Growth Factors in Regenerative Therapy in Furcation Involvements in Humans

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ClinicalTrials.gov Identifier: NCT03180658
Recruitment Status : Recruiting
First Posted : June 8, 2017
Last Update Posted : June 8, 2017
Sponsor:
Information provided by (Responsible Party):
Jing Qiao, Peking University

Brief Summary:
Objective: To compare the effect of guided tissue regeneration (GTR) + concentrated growth factors (CGF) + bone graft and CGF + bone graft in the treat of II° furcations of human mandibular molars. Methods: At least thirty II°furcation involvements in mandibular molars will be included and randomly divided into two groups. The experimental group will accept GTR + CGF + bone graft therapy, and the control group will accept CGF + bone graft therapy. The clinical examination and cone beam computed tomography (CBCT) will be performed at baseline and 1 year post-surgery.

Condition or disease Intervention/treatment Phase
Concentrated Growth Factors Periodontal Regeneration Furcation Defects Procedure: GTR + CGF + bone graft Procedure: CGF + bone graft Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 30 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: The Effect of Concentrated Growth Factors in Regenerative Therapy in Furcation Involvements in Humans
Actual Study Start Date : May 1, 2017
Estimated Primary Completion Date : May 1, 2020
Estimated Study Completion Date : July 1, 2020

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Bone Grafts

Arm Intervention/treatment
Experimental: experimental
GTR+CGF+bone graft, CGF
Procedure: GTR + CGF + bone graft
Guided tissue regeneration (GTR) combined with CGF and bone graft to treat mandibular furcation involvements
Other Name: CGF Centrifuge machine

Active Comparator: controlled
CGF+bone graft
Procedure: CGF + bone graft
CGF combined with bone graft to treat mandibular furcation involvements
Other Name: CGF Centrifuge machine




Primary Outcome Measures :
  1. clinical measurement [ Time Frame: 1 year ]
    Probing depth

  2. clinical parameter [ Time Frame: 1 year ]
    clinical attachment loss


Secondary Outcome Measures :
  1. radiographic parameter [ Time Frame: 1 year ]
    cone beam computerized tomographic scanning



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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • II° furcation involvements in mandibular molars
  • after periodontal therapy.

Exclusion Criteria:

  • not healthy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03180658


Contacts
Contact: qiao jing, doctor 86-13241892143 donaldshushu@aliyun.com

Locations
China, Beijing
Peking university School and Hospital of Stomatology Recruiting
Beijing, Beijing, China, 100081
Contact: jing qiao, doctor         
Sponsors and Collaborators
Jing Qiao
Investigators
Study Chair: yan zu zhang, doctor dean

Responsible Party: Jing Qiao, Principal Investigator, Peking University
ClinicalTrials.gov Identifier: NCT03180658     History of Changes
Other Study ID Numbers: 81600868
First Posted: June 8, 2017    Key Record Dates
Last Update Posted: June 8, 2017
Last Verified: June 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
Furcation Defects
Periodontal Diseases
Mouth Diseases
Stomatognathic Diseases
Mitogens
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action