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Impact of HMGB1 on Diastolic Dysfunction in Hypertensive Patients

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ClinicalTrials.gov Identifier: NCT03177408
Recruitment Status : Not yet recruiting
First Posted : June 6, 2017
Last Update Posted : June 6, 2017
Sponsor:
Information provided by (Responsible Party):
Jing Li, Affiliated Hospital of Hebei University

Brief Summary:
This study evaluated the association between HMGB1 and diastolic dysfunction in hypertensive patients. HMGB1 level were tested in all patients, and diastolic function determined by echocardiographic.

Condition or disease
Diastolic Dysfunction Hypertension Inflammation

Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Impact of HMGB1 on Diastolic Dysfunction in Hypertensive Patients
Estimated Study Start Date : August 15, 2017
Estimated Primary Completion Date : December 31, 2017
Estimated Study Completion Date : December 31, 2017



Primary Outcome Measures :
  1. Differences of HMGB1 levels between hypertensive patients with and without diastolic dysfunction [ Time Frame: on the day of admission ]
    Blood samples of all individuals are collected on the day of admission and HMGB1 levels are tested. Echocardiographic assessment is performed with echocardiography device by using 2.5-3.5 Mega Hertz(MHz) transducer in the lateral decubitis position.


Secondary Outcome Measures :
  1. Differences of HMGB1 levels between grades of diastolic dysfunction [ Time Frame: on the day of admission ]
    Blood samples of all individuals are collected on the day of admission and HMGB1 levels are tested. Echocardiographic assessment is performed with echocardiography device by using 2.5-3.5 Mega Hertz(MHz) transducer in the lateral decubitis position.



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Ages Eligible for Study:   30 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
The study sample is recruited from the patients examined in the physical examination center of our hospital.
Criteria

Inclusion Criteria:

All of the hypertensive patients in both diastolic dysfunction and control groups were either newly diagnosed or were aware of hypertension without using any pharmacotherapy.

Exclusion Criteria:

Individuals already under treatment for hypertension were not include.


Responsible Party: Jing Li, Doctor, Affiliated Hospital of Hebei University
ClinicalTrials.gov Identifier: NCT03177408     History of Changes
Other Study ID Numbers: 2017032901
First Posted: June 6, 2017    Key Record Dates
Last Update Posted: June 6, 2017
Last Verified: June 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Jing Li, Affiliated Hospital of Hebei University:
Diastolic Dysfunction
Hypertension
HMGB1

Additional relevant MeSH terms:
Hypertension
Inflammation
Vascular Diseases
Cardiovascular Diseases
Pathologic Processes