Scalp Block: Hemodynamic Stability and Patient Comfort In Craniotomy Patients (Scalp block)
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|ClinicalTrials.gov Identifier: NCT03177252|
Recruitment Status : Withdrawn (Investigator decided not to go forward with the trial.)
First Posted : June 6, 2017
Last Update Posted : October 22, 2020
|Condition or disease||Intervention/treatment||Phase|
|Tumor, Brain Anesthesia, Local||Drug: Lidocaine Drug: Sodium chloride Drug: Bupivacaine||Phase 1|
Avoidance of hemodynamic fluctuations in the heart rate and or the blood pressure perioperatively, rapid postoperative recovery, and adequate postoperative pain relief are some of the important goals of neurosurgical anesthesia. Scalp block in association with general anesthesia is used to achieve these goals. Previous studies have been published related to the effect of scalp block on the perioperative outcomes on the craniotomy patients. The results reported so far are controversial and one cannot at this point define a positive effect for post-operative pain relief. This disparity in results may be the consequences of the size of the patient population. However scalp block is an accepted practice in the craniotomy patients. The investigators believe this is the first study which assesses the effectiveness of scalp block for asleep craniotomy with the largest sample size study so far conducted in the literature related to this topic. The aim of this study is to assess the effectiveness of scalp block for the perioperative comfort of the craniotomy patients undergoing resection for supratentorial tumors.
After the consent for the participation and enrollment in the study is done, patients will be randomized to two groups, a study group will receive a scalp block with a mixture of 2% lidocaine and 0.5% bupivacaine while the control group will receive the scalp block with saline. Intraoperatively, all patients will be preoxygenated, fentanyl (1-2mcg/kg) will be given and anesthesia will be induced with propofol (1-2mg/kg) and lidocaine (1-1.5mg/kg). Tracheal intubation will be facilitated by using either rocuronium (0.6 mg/kg) or succinylcholine (1-1.5mg/kg) intravenously. The lungs will be ventilated with a fresh gas flow of oxygen for 2 minutes before tracheal intubation with cuffed oral endotracheal tube. Anesthesia will be maintained with inhalational anesthetic Isoflurane, Sevoflurane or Desflurane (0.8-1 MAC) and fentanyl infusion (1-2mcg/kg) with the dose adjusted according to the patient's hemodynamics. Bilateral BIS or EEG to maintain an adequate level of depth of anesthesia will be used whenever feasible. After intubation, a scalp block will be performed. The randomization of the scalp block syringes will be provided by the pharmacy and neither the scalp block performer nor the attending will be aware of the syringe content. To standardize the block, a pain specialist is involved. Response to the pinning will be assessed using the hemodynamic parameters and rescue analgesics (fentanyl bolus 50 - 100 mcg) and/or propofol bolus 50 - 100 mg will be given as a bolus if significant response is noted. Significant response being a rise in the patient's heart rate and/or the blood pressure more than 20% from the patient's baseline heart rate and/or the blood pressure just before pinning. Similarly, response to the surgical incision will be noted and rescue analgesics will be given if needed. Intraoperative propofol requirement and opioid requirements will be recorded. The post-operative orders for pain control will be standardized for all the patients.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||0 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Care Provider)|
|Primary Purpose:||Supportive Care|
|Official Title:||Scalp Block: Hemodynamic Stability and Patient Comfort In Craniotomy Patients|
|Estimated Study Start Date :||October 1, 2020|
|Estimated Primary Completion Date :||September 30, 2021|
|Estimated Study Completion Date :||September 30, 2021|
Experimental: Scalp block with lidocaine and bupivacaine
-2% lidocaine will be given
-0.5% bupivacaine will be given
Placebo Comparator: Scalp block with saline
Drug: Sodium chloride
-Normal saline will be given
- Overall perioperative comfort of the patient as measured by hemodynamic fluctuations [ Time Frame: Up to 48 hours ]Hemodynamic fluctuations during pinning of the head with a Mayfield head-holder and skin incision which represents the most extreme painful stimulation for the entire surgery (significant response being rise in the patient's heart rate and/or the blood pressure more than 20% from the patient's baseline heart rate and/or the blood pressure prior pinning)
- Overall perioperative comfort as measured by opioid requirements [ Time Frame: Up to 48 hours ]Overall perioperative opioid requirements until the next morning of the surgery as an overall evaluation of the patient's comfort.
- Cost-effectiveness of scalp block [ Time Frame: Up to 48 hours ]
Scalp block for the craniotomy
- lowers overall administration of opioids, which will decrease the side effects of opioids
- improve the immediate postoperative pain which may decrease the occurrence of chronic postoperative pain and
- may result in the early discharge from the hospital contributing to shorter hospital stay reducing the financial burden for both the patient and the hospital.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03177252
|Principal Investigator:||Umeshkumar Athiraman, M.D.||Washington University School of Medicine|