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Parasitic Causes of Secretory Diarrhea in Children and Chronically Ill Adult.

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ClinicalTrials.gov Identifier: NCT03166670
Recruitment Status : Unknown
Verified May 2017 by Asmaa Elderwy, Assiut University.
Recruitment status was:  Not yet recruiting
First Posted : May 25, 2017
Last Update Posted : October 26, 2017
Sponsor:
Information provided by (Responsible Party):
Asmaa Elderwy, Assiut University

Brief Summary:
Diarrhea is one of the most common reasons for people to seek medical advice - but it can range from being a mild, temporary condition, to be life threading condition. It is estimated that there are 2 billion cases of diarrheal disease every year globally, and that 1.9 million children below the age of 5 years, mostly in developing countries, die annually.

Condition or disease Intervention/treatment
Diarrhea, Secretory Diagnostic Test: stool examination Diagnostic Test: real time polymerase chain reaction

Detailed Description:
Secretory diarrhea has many causes as infection with bacteria, viruses or protozoa. It results from increased chloride secretion, decreased sodium absorption, or increased mucosal permeability . Parasitic pathogens induce Secretory diarrhea as they infect and damage the absorptive villus tips, leaving Secretory crypts unbalanced, to cause net secretion and diarrhea. Parasitic causes include Cryptosporidium parvum or hominis ,Capillaria philippinensis and Giardia lamblia. Cryptosporidiosis is also recognized as a cause of prolonged and persistent diarrhea in children and persons with impaired immunity. The disease is transmitted via the fecal-oral route from infected hosts. It can be also transmitted following animal contact, ingestion of water (mainly during swimming), or through food. Cryptosporidium has emerged as the most frequently recognized cause of water-associated outbreaks of gastroenteritis. This is because of the oocyst stage in its life cycle; Cryptosporidium can resist disinfection, including chlorination, and can survive for a prolonged period in the environment.

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Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Other
Time Perspective: Cross-Sectional
Official Title: Parasitic Causes of Secretory Diarrhea in Children and Chronically Ill Adult.
Estimated Study Start Date : December 1, 2017
Estimated Primary Completion Date : July 1, 2018
Estimated Study Completion Date : October 30, 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Diarrhea

Group/Cohort Intervention/treatment
study group
children with acute secretory diarrhea
Diagnostic Test: stool examination
collection of stool specimen and microscopic examination for parasites

Diagnostic Test: real time polymerase chain reaction
evaluation of genotype of cryptosporidium in stool specimen

Control group
normal healthy children
Diagnostic Test: stool examination
collection of stool specimen and microscopic examination for parasites

Diagnostic Test: real time polymerase chain reaction
evaluation of genotype of cryptosporidium in stool specimen




Primary Outcome Measures :
  1. percentage of patients with positive stool analysis for cryptosporidium [ Time Frame: 2 days ]
    Use of microscopic examination and real time polymerase chain reaction



Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

-Children presented with secretory diarrhea(acute watery diarrhea) attend to out clinic lab of Assiut University pediatric hospital or admitted in pediatric hospital(gastroenterology department) during the study period.

2-adult patients having acute watery diarrhea attend to out clinic labs of Assiut University hospital or admitted in gastroenterology, nephrology and oncology department of hospital during the study period.

Criteria

Inclusion Criteria:

  1. Children presented with secretory diarrhea(acute watery diarrhea) attend to out clinic lab of Assiut University pediatric hospital or admitted in pediatric hospital(gastroenterology department) during the study period.
  2. adult patients having acute watery diarrhea attend to out clinic labs of Assiut University hospital or admitted in gastroenterology, nephrology and oncology department of hospital during the study period.

Exclusion Criteria:

  1. viral and bacterial causes of diarrhea
  2. Patients who were already diagnosed as intestinal inflammatory disease as irritable bowel syndrome.
  3. Autoimmune conditions, such as ulcerative colitis, Crohn's disease and coeliac disease.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03166670


Contacts
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Contact: Hebat_Allah G Rashed, Professor.D 01003997231 hebagr@yahoo.com

Sponsors and Collaborators
Assiut University
Investigators
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Principal Investigator: Asmaa M Abd elaziz, MD Assuit University, Faculty of medicine

Publications:
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Responsible Party: Asmaa Elderwy, Principal Investigator, Assiut University
ClinicalTrials.gov Identifier: NCT03166670     History of Changes
Other Study ID Numbers: PSDCC
First Posted: May 25, 2017    Key Record Dates
Last Update Posted: October 26, 2017
Last Verified: May 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
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Diarrhea
Chronic Disease
Signs and Symptoms, Digestive
Signs and Symptoms
Disease Attributes
Pathologic Processes