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Carbon Dioxide Laser and Cryotherapy in Treatment of Warts

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ClinicalTrials.gov Identifier: NCT03166137
Recruitment Status : Not yet recruiting
First Posted : May 25, 2017
Last Update Posted : May 25, 2017
Sponsor:
Information provided by (Responsible Party):
Kadija Yousef Badawy, Assiut University

Brief Summary:
Viral warts are common skin conditions seen in both children and adults. Human papilloma virus is responsible for verrucae. Cutaneous manifestation of the human papillomavirus, are extremely common particularly on the hands and feet. Warts can induce hard, thickened skin, black pinpoints, pain or tenderness with significant morbidity for the patients.

Condition or disease Intervention/treatment Phase
Common Warts Device: Carbon dioxide laser Device: Cryotherapy Not Applicable

Detailed Description:

A range of types of wart have been identified, varying in shape and site affected, as well as the type of human papillomavirus involved.

These include:

  • Common wart (Verruca vulgaris).
  • Flat wart (Verruca plana).
  • Filiform or digitate wart.
  • Genital wart (venereal wart, Condyloma acuminatum, Verruca acuminata).
  • Mosaic wart.
  • Periungual wart.
  • Plantar wart (verruca, Verruca plantaris). Despite the presence of several therapeutic options, treatment of warts can present a challenge and they are not uniformly effective. Viral warts often disappear without treatment. In case of pain, discomfort and long duration they can be treated . Treatment options include cryotherapy, electrocautery, salicylic acid, immune therapy, minor surgery or laser surgery.

Common warts have a distinctive appearance and can usually be diagnosed with the unaided eye; however, early growth stages and post-treatment warts are less easily diagnosed. Published dermoscopic features of common warts include frogspawn pattern, mosaic pattern and dotted, linear, globular or coiled vessels. Mosaic pattern consists of relatively flattened, rounded structures of similar size, resembling a jigsaw puzzle. Frogspawn pattern consists of densely packed papillae, each containing red dot or loop, surrounded by a whitish halo. Vascular structures seen dermoscopically in common warts as red or black dotted, linear, globular and coiled vessels. Haemorrhages are possible additional features, with black dots corresponding to thrombosed vessels. Hairpin vessels were usually seen in non-wart lesions.

In this study, we aim to compare two therapeutic modalities, the clinical effectiveness and safety of carbon dioxide laser and cryotherapy in the treatment of viral warts together with dermoscopic evaluation of viral warts before and after treatment.


Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Comparative Evaluation of Carbon Dioxide Laser and Cryotherapy by Dermoscopy in Treatment of Viral Wart
Estimated Study Start Date : August 1, 2017
Estimated Primary Completion Date : August 1, 2018
Estimated Study Completion Date : August 1, 2019

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Warts

Arm Intervention/treatment
Experimental: Carbon dioxide laser group
(group A): thirty patients will be treated by application of carbon dioxide laser.
Device: Carbon dioxide laser
Radiation by carbon dioxide laser

Active Comparator: Cryotherapy group
(group B): thirty patients will be treated by cryotherapy application.
Device: Cryotherapy
Device using cooling effect




Primary Outcome Measures :
  1. Number and size of the lesions. [ Time Frame: Two months ]
    Dermoscopic evaluation



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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Patients with common warts male or females any age.
  2. Patient is able to read and understand English and will give written informed consent to participate.
  3. Patient elects to undergo carbon dioxide laser therapy or cryotherapy for treatment of common warts.
  4. Warts to be treated will be located only on the hands.

Exclusion Criteria:

  1. Non cooperative patients.
  2. Patients on other lines of treatment.
  3. Pregnant and lactating females.
  4. Patients receiving topical treatment in the previous two weeks.
  5. Secondary infection.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03166137


Contacts
Contact: Nagwa Essa, PD 00201280994337 nagwaessa@yahoo.com
Contact: Hanan Ahmed, MD 01064447881 hanan_morsy2003@yahoo.com

Sponsors and Collaborators
Assiut University

Publications of Results:
Responsible Party: Kadija Yousef Badawy, Principal Investigator, Assiut University
ClinicalTrials.gov Identifier: NCT03166137     History of Changes
Other Study ID Numbers: Laser,Cryotherapy,Wart
First Posted: May 25, 2017    Key Record Dates
Last Update Posted: May 25, 2017
Last Verified: May 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Kadija Yousef Badawy, Assiut University:
Warts,Laser,Cryotherapy

Additional relevant MeSH terms:
Warts
Papillomavirus Infections
DNA Virus Infections
Virus Diseases
Skin Diseases, Viral
Tumor Virus Infections
Skin Diseases, Infectious
Skin Diseases