Effect of Genetic Polymorphisms on Platinum Based Chemotherapy in Non Small Cell Lung Cancer
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This Study evaluate the effect of Polymorphism in the Excision repair cross-complementing group 5 (ERCC5) (rs1047768 and rs751402) gene on the clinical outcome of Platinum-based regimens used in the treatment of Non-Small Cell Lung Cancer (NSCLC) patients
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
clinical oncology department at Al Demerdash hospital
Newly diagnosed with immunohistochemically and pathologically confirmed non-small cell lung cancer (NSCLC).
Eastern Cooperative Oncology Group performance status (ECOG PS) = 0-2.
Age >18 years.
Adequate bone marrow reserve
Presence of Central nervous system(CNS) metastases.
Inadequate liver function
Inadequate renal function
Serious comorbid systemic disorder incompatible with the study.