Protein Ingestion Before Training Low
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|ClinicalTrials.gov Identifier: NCT03147001|
Recruitment Status : Completed
First Posted : May 10, 2017
Last Update Posted : May 10, 2017
University of Aarhus
Innovation Fund Denmark
Information provided by (Responsible Party):
Mette Hansen, University of Aarhus
A randomized interventions study using a crossover design. Ten well trained triathletes or bikeriders will be included for to undergo two trail separated by about 3 weeks. The night before the trail each subject will performe a high intense interval trainings session on an ergometer bike. during the night an infusion of aminoacid tracers will be initiated. The subject is woken at 6.30 a.m. Blood samples and a musclebiopsy will be collected prior to the morning bike ride at 8.00a.m. Immediately before the morning bike ride is started the subject will ingest a drink of 0,5g protein or a non-caloric placebo (random order). During the bike ride and the following 4,5 hours blood will be drawn with regular intervals. at time point 0, 60 and 180 min after the training session biopsies are collected.
|Condition or disease||Intervention/treatment||Phase|
|Protein Metabolism||Other: Protein ingestion Other: Non-caloric placebo ingestion||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||9 participants|
|Intervention Model:||Crossover Assignment|
|Masking Description:||Masking was done by providing similar tasting drinks at both trails. One was placebo, one was protein a drink|
|Primary Purpose:||Health Services Research|
|Official Title:||Nutritional Strategies for Optimizing Adaptations and Recovery Following Training 'Low'.|
|Actual Study Start Date :||April 30, 2016|
|Actual Primary Completion Date :||January 10, 2017|
|Actual Study Completion Date :||January 10, 2017|
Experimental: Protein ingestion
Subjects ingested protein drinks
Other: Protein ingestion
A protein drink was ingested prior to the 90min bike ride in one of the completed trails (order randomised).
Placebo Comparator: Placebo
Subjects ingested a non-caloric placebo drink
Other: Non-caloric placebo ingestion
A placebo drink was ingested prior to the 90min bike ride in one of the completed trails (order randomised).
Primary Outcome Measures :
- Muscle protein fractional synthetic rate (FSR) [ Time Frame: FSR was measure over at time period of six hours ]
Secondary Outcome Measures :
- Tracer kinetics dilution model [ Time Frame: six hours ]A-V tracer dilution model was applied across the forearm.
- Muscle signalling [ Time Frame: Determined in biopsies sampled before and immediatly after 90min exercise in addition to one and four hours after exercise. ]Muscle signalling will be determined using western blotting in each muscle biopsy
- Nitrogen excretion [ Time Frame: Urine is collected during two periods. Collection period one: 12 hours prior to morning exercise. Collection period 2: During and four hours following exercise. Blood samples is drawn repeatedly from before to four hours after exercise. ]nitrogen excretion is determined by Plasma and urinary carbide analysis as well as plasma NH4+.
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