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Trial record 64 of 228 for:    yeast

Kinetics of Serum β-D-glucan During Peritonitis With Candida in Resuscitation (PERIGLUC1)

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ClinicalTrials.gov Identifier: NCT03140748
Recruitment Status : Recruiting
First Posted : May 4, 2017
Last Update Posted : October 4, 2018
Sponsor:
Information provided by (Responsible Party):
Centre Hospitalier Universitaire, Amiens

Brief Summary:
Intraabdominal fungal infections with Candida are constantly increasing. Their diagnosis and treatment is difficult. Morbidity and mortality are high. Β-D-Glucan has been proposed as a marker of systemic fungal infection in candidemia. Moreover, its kinetics is associated with therapeutic success. On the other hand, there are no data on intraabdominal infections that are much more frequent. The objective of the study is to evaluate the initial levels of β-D-glucan and its daily kinetics during the treatment of fungal peritonitis in resuscitation compared to a control group with a yeast-free peritonitis.

Condition or disease Intervention/treatment Phase
Peritonitis Infectious Candida Infection Other: To evaluate the initial levels and kinetics of serum β-D-glucan Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 60 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Screening
Official Title: Kinetics of Serum β-D-glucan During Peritonitis With Candida in Resuscitation
Actual Study Start Date : May 1, 2018
Estimated Primary Completion Date : June 1, 2020
Estimated Study Completion Date : June 1, 2020

Arm Intervention/treatment
Patients with fungal peritonitis Other: To evaluate the initial levels and kinetics of serum β-D-glucan
To evaluate the initial levels and kinetics of serum β-D-glucan during fungal peritonitis compared to a control group of yeast-free peritonitis

Patients with peritonitis without yeast Other: To evaluate the initial levels and kinetics of serum β-D-glucan
To evaluate the initial levels and kinetics of serum β-D-glucan during fungal peritonitis compared to a control group of yeast-free peritonitis




Primary Outcome Measures :
  1. Blood determination of serum β-D-glucan kinetics in patients with peritonitis [ Time Frame: 28 days ]
    Blood determination of serum β-D-glucan kinetics in patients with peritonitis



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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Major Patient (age ≥ 18 years)
  • Community or associated peritonitis, operated and hospitalized in resuscitation
  • Affiliation to a social security scheme

Exclusion Criteria:

  • Allergy known to echinocandins
  • Dying Patient
  • Limitation of care
  • Predictable duration of follow-up ≤ 10 days
  • Transfusion within 3 months
  • Patient minor, patient under guardianship or curatorship

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03140748


Contacts
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Contact: Hervé DUPONT, PhD +33322668375 dupont.herve@chu-amiens.fr

Locations
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France
CHU Amiens Picardie Recruiting
Amiens, Picardie, France, 80054
Contact: Hervé DUPONT, p    +33322668375    dupont.herve@chu-amiens.fr   
Sponsors and Collaborators
Centre Hospitalier Universitaire, Amiens

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Responsible Party: Centre Hospitalier Universitaire, Amiens
ClinicalTrials.gov Identifier: NCT03140748     History of Changes
Other Study ID Numbers: PI2016_843_0036
First Posted: May 4, 2017    Key Record Dates
Last Update Posted: October 4, 2018
Last Verified: October 2018

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Peritonitis
Candidiasis
Infection
Intraabdominal Infections
Peritoneal Diseases
Digestive System Diseases
Mycoses