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Clinical Applications of Advanced Ophthalmic Imaging

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT03135327
Recruitment Status : Recruiting
First Posted : May 1, 2017
Last Update Posted : November 7, 2019
Information provided by (Responsible Party):
Jianhua (Jay) Wang, MD, PhD, University of Miami

Brief Summary:
This study to determine the clinical application of advanced ophthalmic imaging devices such as optical coherence tomography (OCT), retinal function imager (RFI), slit-lamp biomicroscopy (SLB), PERG in diseased eyes and normal controls.

Condition or disease Intervention/treatment
Multiple Sclerosis Dry Eye Syndromes Diabetic Retinopathy Presbyopia Myopia Dementia Other: No intervention

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Study Type : Observational
Estimated Enrollment : 5000 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Clinical Applications of Advanced Ophthalmic Imaging
Actual Study Start Date : January 1, 2007
Estimated Primary Completion Date : December 31, 2020
Estimated Study Completion Date : December 31, 2020

Resource links provided by the National Library of Medicine

Intervention Details:
  • Other: No intervention
    No intervention

Primary Outcome Measures :
  1. Retinal microstructure using OCT. [ Time Frame: 10 years ]
    Optical coherence tomography is used to measure the thickness of intraretinal layers. The measurement is in micrometer.

  2. Retinal vasculature by optical coherence tomography angiography (OCTA) [ Time Frame: 10 years ]
    Retinal vascular network density in percentage.

  3. Conjunctival vasculature by functional slit-lamp (FSLB) [ Time Frame: 10 years ]
    Conjunctival vascular network density in percentage.

  4. Corneal epithelial thickness and tear film thickness [ Time Frame: 10 years ]
    Corneal epithelial thickness in micrometers measured using ultra-high resolution OCT.

Secondary Outcome Measures :
  1. Retinal blood flow velocity by retinal function imager (RFI) [ Time Frame: 10 years ]
    Retinal blood flow velocity in mm/s

  2. Conjunctival blood flow velocity by functional slit-lamp (FSLB) [ Time Frame: 10 years ]
    Conjunctival blood flow velocity in mm/s

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
patients with diseases and normal controls.

Inclusion Criteria:

Self-reported normal healthy subjects Clinical diagnosis of Alzheimer's Disease, mild cognitive impairment, multiple sclerosis, dry eye, myopia, diabetic.

Who can keep the eye open for imaging.

Exclusion Criteria: who can not read and sign the ICF.


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT03135327

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Contact: Jianhua Wang, MD, PhD 3054825010

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United States, Florida
Bascom Palmer Eye Institute Recruiting
Miami, Florida, United States, 33136
Contact: Jianhua Wang, MD, PHD    305-482-5010   
Sponsors and Collaborators
University of Miami

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Responsible Party: Jianhua (Jay) Wang, MD, PhD, Associate Professor, University of Miami Identifier: NCT03135327     History of Changes
Other Study ID Numbers: 20070492
First Posted: May 1, 2017    Key Record Dates
Last Update Posted: November 7, 2019
Last Verified: November 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Multiple Sclerosis
Diabetic Retinopathy
Dry Eye Syndromes
Demyelinating Autoimmune Diseases, CNS
Autoimmune Diseases of the Nervous System
Nervous System Diseases
Demyelinating Diseases
Autoimmune Diseases
Immune System Diseases
Retinal Diseases
Eye Diseases
Diabetic Angiopathies
Vascular Diseases
Cardiovascular Diseases
Diabetes Complications
Diabetes Mellitus
Endocrine System Diseases
Refractive Errors
Lacrimal Apparatus Diseases