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QUILT-2.022 NANT-008 in Combination w/ 5-fluorouracil, Bevacizumab, Leucovorin & Oxaliplatin in Subjects With Pancreatic Cancer

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ClinicalTrials.gov Identifier: NCT03127124
Recruitment Status : Recruiting
First Posted : April 25, 2017
Last Update Posted : August 13, 2018
Sponsor:
Information provided by (Responsible Party):
NantPharma, LLC

Brief Summary:
This is a phase 1b/2 study to evaluate the safety and efficacy of NANT-008 in combination with 5-fluorouracil, bevacizumab, leucovorin, and oxaliplatin in patients with metastatic pancreatic adenocarcinoma.

Condition or disease Intervention/treatment Phase
Pancreatic Adenocarcinoma Metastatic Drug: NANT-008 Drug: Fluorouracil Injectable Product Drug: Avastin Injectable Product Drug: Leucovorin Calcium Injection Drug: Eloxatin Injectable Product Phase 1 Phase 2

Detailed Description:
Phase 1b is designed to evaluate the recommended phase 2 dose (RP2D) of NANT-008 and dose-limiting toxicities (DLTs) of NANT-008 in combination with metronomic 5-FU, bevacizumab, leucovorin, and oxaliplatin in subjects with advanced metastatic pancreatic carcinoma. In phase 2, subjects will receive the combination of RP2D of NANT-008 from phase 1b in combination with metronomic 5-FU, bevacizumab, leucovorin, and oxaliplatin. Phase 2 is designed to evaluate the efficacy of the tested regimen as assessed by 1-year survival rate in subjects with advanced metastatic pancreatic adenocarcinoma.

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 64 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: An Open-label, Multicenter, Single-arm, Phase 1b/2 Study of NANT-008 in Combination With 5-fluorouracil, Bevacizumab, Leucovorin, and Oxaliplatin in Patients With Metastatic Pancreatic Adenocarcinoma.
Actual Study Start Date : February 27, 2018
Estimated Primary Completion Date : October 2018
Estimated Study Completion Date : December 2018

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: NANT-008 in combination with other agents
NANT-008 will be administered in combination with 5-fluorouracil, bevacizumab, leucovorin, and oxaliplatin in patients with metastatic pancreatic adenocarcinoma.
Drug: NANT-008
Paclitaxel: benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-(2aR, 4S, 4aS, 6R, 9S, 11S, 12S, 12aR, 12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a, 3, 4, 4a, 5, 6, 9, 10, 11, 12, 12a, 12b-dodecahydro-4,11-dihydroxy-4a, 8, 13, 13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-y1ester,(αR,βS)-(9CI)

Drug: Fluorouracil Injectable Product
5-fluoro-2,4 (1H,3H)-pyrimidinedione.

Drug: Avastin Injectable Product
Recombinant humanized monoclonal IgG1 antibody

Drug: Leucovorin Calcium Injection
Calcium N -[p -[[[(6RS )-2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl]methyl]amino]benzoyl]-L-glutamate (1:1).

Drug: Eloxatin Injectable Product
cis-[(1 R,2 R)-1,2-cyclohexanediamine-N,N'] [oxalato(2-)- O,O'] platinum.




Primary Outcome Measures :
  1. Phase 1b Primary Endpoint [ Time Frame: 12 weeks ]
    Determine the recommended phase 2 dose (RP2D) of NANT-008 and dose-limiting toxicities (DLTs) of NANT-008

  2. Phase 2 Primary Endpoint [ Time Frame: 1 year ]
    Evaluate the efficacy of the tested regimen as assessed by the 1 year survival rate


Secondary Outcome Measures :
  1. Phase 1b Secondary Endpoint [ Time Frame: 12 weeks ]
    To determine overall safety profile of the combination treatment

  2. Phase 2 Secondary Endpoint [ Time Frame: 1 year ]
    Obtain additional data on the safety and tolerance of this study treatment at the RP2D

  3. Phase 2 Secondary Endpoint [ Time Frame: 1 year ]
    Obtain preliminary data on the Objective response rate (ORR)

  4. Phase 2 Secondary Endpoint [ Time Frame: 1 year ]
    Obtain preliminary data on the Progression-free survival (PFS)

  5. Phase 2 Secondary Endpoint [ Time Frame: 1 year ]
    Obtain preliminary data on the Overall survival (OS)

  6. Phase 2 Secondary Endpoint [ Time Frame: 1 year ]
    Obtain preliminary data on the Duration of Response (DOR)

  7. Phase 2 Secondary Endpoint [ Time Frame: 1 year ]
    Obtain preliminary data on the Patient-reported outcomes (PROs) of pancreatic cancer symptoms.



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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Male or female subject is between ≥ 18 and ≤ 65 years of age at the time of signing the informed consent form (ICF).
  2. Able to understand and provide a signed informed consent that fulfills the relevant IRB or IEC guidelines.
  3. Histologically confirmed, unresectable, locally advanced or metastatic pancreatic adenocarcinoma.
  4. ECOG performance status of 0 to 1.
  5. Have at least 1 measurable lesion and/or non-measurable disease evaluable according to RECIST Version 1.1.
  6. Have not received any prior treatment other than radiation therapy for symptomatic pain relief.
  7. Resolution of all toxic side effects of prior chemotherapy, radiotherapy, or surgical procedures to CTCAE grade ≤ 1, with the exception of alopecia.
  8. Must be willing to provide pre- and post-treatment blood samples for exploratory analyses.
  9. Ability to attend required study visits and return for adequate follow-up, as required by this protocol.
  10. Must have a recent FFPE tumor biopsy specimen following the conclusion of the most recent anticancer treatment and be willing to release the specimen for tumor molecular profiling analysis. If an historic specimen is not available, the subject must be willing to undergo a biopsy during the screening period.
  11. Agreement to practice effective contraception (both male and female subjects, if the risk of conception exists).
  12. Must have a stable, functioning stent at least 2 weeks before the beginning of the study (metal stents are preferred as per NCCN guidelines) if subject has had a previous biliary or pancreatic duct obstruction requiring stent placement.

Exclusion Criteria:

  1. History of previous systemic chemotherapy or investigational therapy.
  2. History of other active malignancies or brain metastasis except: controlled basal cell carcinoma or squamous cell carcinoma; prior history of in situ cancer (eg, breast, melanoma, squamous cell carcinoma of the skin, cervical) and > 5 years without evidence of disease; prior history of prostate cancer that is not under active systemic treatment (except hormonal therapy) and with undetectable PSA (< 0.2 ng/mL).
  3. Inadequate organ function, evidenced by the following laboratory results:

    1. White blood cell (WBC) count < 3,500 cells/mm3
    2. Absolute neutrophil count < 1,500 cells/mm3.
    3. Platelet count < 100,000 cells/mm3.
    4. Hemoglobin < 9 g/dL.
    5. Total bilirubin greater than the upper limit of normal (ULN) at time of enrollment; unless the subject has known history of Gilbert's syndrome.
    6. Aspartate aminotransferase (AST [SGOT]) or alanine aminotransferase (ALT [SGPT]) > 2.5 × ULN (> 5 × ULN in subjects with liver metastases).
    7. Alkaline phosphatase levels > 2.5 × ULN (> 5 × ULN in subjects with liver metastases, or >10 × ULN in subjects with bone metastases).
    8. Serum creatinine > 2.0 mg/dL or 177 μmol/L.
    9. International normalized ratio (INR) or activated partial thromboplastin time (aPTT) or partial thromboplastin time (PTT) >1.5 × ULN.
  4. Pre-existing peripheral neuropathy > grade 1 based on NCI CTCAE V4.03.
  5. Dihydropyrimidine dehydrogenase gene polymorphism (DPYD*2A) (must be tested prior to inclusion).
  6. Current chronic daily treatment (continuous for > 3 months) with systemic corticosteroids (dose equivalent to or greater than 10 mg/day methylprednisolone), excluding inhaled steroids. Short-term steroid use to prevent IV contrast allergic reaction or anaphylaxis in subjects who have known contrast allergies is allowed.
  7. Positive results of screening test for human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis C virus (HCV).
  8. Undergone major surgery, other than diagnostic surgery (ie, surgery done to obtain a biopsy for diagnosis without removal of an organ), within 4 weeks prior to day 1 of treatment in this study or surgical wound has not fully healed.
  9. History of connective tissue disorders (eg, lupus, scleroderma, arteritis nodosa).
  10. Evidence of gastric ulcers, gastrointestinal fistulas, and gastrointestinal perforations.
  11. History of interstitial lung disease, history of slowly progressive dyspnea and unproductive cough, sarcoidosis, silicosis, idiopathic pulmonary fibrosis, pulmonary hypersensitivity pneumonitis or multiple allergies that in the opinion of the Investigator may put them at increased risk of interstitial pneumonitis.
  12. Uncontrolled hypertension (systolic > 150 mm Hg and/or diastolic > 100 mm Hg) or clinically significant (ie, active) cardiovascular disease, cerebrovascular accident/stroke, or myocardial infarction within 6 months prior to first study medication; unstable angina; congestive heart failure of New York Heart Association grade 2 or higher; or serious cardiac arrhythmia requiring medication.
  13. Recent history of clinically significant hemoptysis.
  14. Known hypersensitivity to any component of the study medication(s).
  15. Pregnant and nursing women.
  16. Assessed by the investigator to be unable or unwilling to comply with the requirements of the protocol.
  17. Concurrent or prior use of a strong CYP3A4 inhibitor (including ketoconazole, itraconazole, posaconazole, clarithromycin, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, voriconazole, and grapefruit products) or strong CYP3A4 inducers (including phenytoin, carbamazepine, rifampin, rifabutin, rifapentin, phenobarbital, and St John's Wort) within 14 days before study day 1.
  18. Concurrent or prior use of a strong CYP2C8 inhibitor (gemfibrozil) or moderate CYP2C8 inducer (rifampin) within 14 days before study day 1.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03127124


Contacts
Contact: NantPharma Clinical Review Team 800-988-6083 clinical.trials@NantKwest.com

Locations
United States, California
Chan Soon-Shiong Institutes for Medicine Recruiting
El Segundo, California, United States, 90245
Contact: Nant Pharma Clinical Review Team    800-988-6083    clinical.trials@NantKwest.com   
Sponsors and Collaborators
NantPharma, LLC

Responsible Party: NantPharma, LLC
ClinicalTrials.gov Identifier: NCT03127124     History of Changes
Other Study ID Numbers: QUILT-2.022
First Posted: April 25, 2017    Key Record Dates
Last Update Posted: August 13, 2018
Last Verified: August 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Studies a U.S. FDA-regulated Drug Product: Yes
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
Adenocarcinoma
Carcinoma
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Bevacizumab
Oxaliplatin
Fluorouracil
Levoleucovorin
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Physiological Effects of Drugs
Growth Inhibitors
Antineoplastic Agents
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Antimetabolites, Antineoplastic
Immunosuppressive Agents
Immunologic Factors
Antidotes
Protective Agents