Frozen-thawed Embryo Transfer in a Naturally Stimulated Cycle: Does hCG Triggering Bring Any Advantage in Comparison to Testing LH Surge With Home Tests?
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|ClinicalTrials.gov Identifier: NCT03115320|
Recruitment Status : Terminated (High cancellation rate in LH test group in interim analysis)
First Posted : April 14, 2017
Last Update Posted : June 4, 2020
|Condition or disease||Intervention/treatment||Phase|
|Infertility||Drug: Human chorionic gonadotropin Other: Home ovulation test||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||62 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||A Protocol for a Randomized, Two-Parallel-group Study to Compare the Efficacy of Testing LH Surge at Home Versus Medically Triggered Ovulation With hCG (Pregnyl®) in the Naturally Stimulated Cycle in the Frozen-thawed Embryo Transfer|
|Actual Study Start Date :||January 2017|
|Actual Primary Completion Date :||November 2019|
|Actual Study Completion Date :||December 2019|
Experimental: Pregnyl (Human chorionic gonadotropin)
In this group, patients have natural cycle in frozen-thawed embryo transfer and the ovulation is confirmed by administration of hCG (Pregnyl® 5000 IU). The day of transferring embryo is depending on the day of administration of hCG and the age of the embryo. The day zero day is defined by ovulation triggered by hCG.
Drug: Human chorionic gonadotropin
Human chorionic gonadotropin (Pregnyl, 5000IU) is used in the medication group to confirme the ovulation.
Other Name: Home ovulation test
Home ovulation test
The patients randomized to the LH surge group perform the ovulation home test daily from the urine. Thus, the ovulation in this group is corfimed by the urine test. The day of transferring embryo is depending on the positive ovulation test and the age of the embryo. The day zero day is defined by positive ovulation test.
Other: Home ovulation test
The ovulation in the natural menstrual cycle is confirmed by the home ovulation tests from the urine.
- Live birth rate [ Time Frame: At possible delivery (about 40 weeks) ]
- Ongoing pregnancy rate [ Time Frame: After two weeks ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03115320
|Tampere University Hospital|
|Principal Investigator:||Helena Tinkanen||Tampere University Hospital|