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Trial record 16 of 40 for:    "Hashimoto thyroiditis" OR "Hashimoto Disease"

Involvement of Viral Infections in the Pathogenesis of Chronic Lymphocytic Thyroiditis (Etude thyrovir)

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ClinicalTrials.gov Identifier: NCT03114267
Recruitment Status : Completed
First Posted : April 14, 2017
Last Update Posted : April 14, 2017
Sponsor:
Information provided by (Responsible Party):
Centre Hospitalier Universitaire, Amiens

Brief Summary:

Autoimmune diseases represent a heterogeneous group of pathologies whose etiopathogenic mechanisms are most often unknown. Autoimmune diseases are the leading cause of morbidity and mortality in young women and autoimmune thyroid diseases are the most common.

Viral infections are the main environmental factors suspected of triggering autoimmune diseases. Several viruses are certainly involved, all of which are possibly capable of triggering an autoimmune response. However, the precise identification of the viruses involved remains to be established.

It has been shown for the first time by the 2005 PHRC that enteroviral RNA is present in perioperative specimens of thyroid tissue. However, this case-control study did not show any difference between the thyroid group and the group other thyroid pathologies It has been recently published that Parvovirus is possibly involved in thyroiditis: the parvoviral genome is present in the thyroid tissue of Hashimoto thyroiditis operated and more precisely is present within the thyrocytes itself.


Condition or disease Intervention/treatment
Autoimmune Diseases Chronic Lymphocytic Thyroiditis Other: Comparison of the prevalences of the parvovirus genome

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Study Type : Observational
Actual Enrollment : 64 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Involvement of Viral Infections in the Pathogenesis of Chronic Lymphocytic Thyroiditis
Actual Study Start Date : January 6, 2012
Actual Primary Completion Date : January 6, 2015
Actual Study Completion Date : January 6, 2015

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Group/Cohort Intervention/treatment
Patient with chronic lymphocytic thyroiditis Other: Comparison of the prevalences of the parvovirus genome
Comparison of the prevalences of the parvovirus genome between cases and controls and then of other viruses according to the results of parvoviruses and data from the literature

Healthy subjects Other: Comparison of the prevalences of the parvovirus genome
Comparison of the prevalences of the parvovirus genome between cases and controls and then of other viruses according to the results of parvoviruses and data from the literature




Primary Outcome Measures :
  1. Analysis of the viral genome by PCR carried out in the Virology department, Analysis of the presence of capsid protein [ Time Frame: 1 day ]


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients were recruited after PHRC 2005. Written information for the extension of the study will be sent with a copy of the summary of the scientific publication on Enterovirus (PHRC 2005).
Criteria

Inclusion Criteria:

  • Patients participating in PHRC 2005 "involvement of enteroviruses in TLC pathogenesis"
  • Inclusion of TLC: presence of a significant lymphocyte infiltrate within the thyroid parenchyma defined by the presence of clusters of more than 30 to 50 lymphocytes
  • Inclusion of controls: absence of significant lymphocyte infiltrate

Exclusion Criteria:

  • Persons refusing to participate in research

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03114267


Locations
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France
CHU Amiens Picardie
Amiens, Picardie, France, 80054
Sponsors and Collaborators
Centre Hospitalier Universitaire, Amiens

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Responsible Party: Centre Hospitalier Universitaire, Amiens
ClinicalTrials.gov Identifier: NCT03114267     History of Changes
Other Study ID Numbers: PI11-PR-DESAILLOUD-1
First Posted: April 14, 2017    Key Record Dates
Last Update Posted: April 14, 2017
Last Verified: April 2017

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Thyroiditis
Hashimoto Disease
Thyroiditis, Autoimmune
Autoimmune Diseases
Virus Diseases
Immune System Diseases
Thyroid Diseases
Endocrine System Diseases