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Sebum Collection and Skin Barrier Function Analysis (Sebum)

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ClinicalTrials.gov Identifier: NCT03112876
Recruitment Status : Completed
First Posted : April 13, 2017
Last Update Posted : April 13, 2017
Sponsor:
Information provided by (Responsible Party):
University of California, Davis

Brief Summary:

The goal is this study is to evaluate how the skin surface lipid composition is correlated with overall sebum production, barrier function, and inflammatory disease status. We hypothesize that there will be differences in the skin surface composition among subjects of various groups:

  1. Young vs older healthy population
  2. Atopic dermatitis vs Acne vs Healthy controls
  3. Active smokers vs non-smoker controls

Condition or disease Intervention/treatment
Smoking Acne Atopic Dermatitis Aging Other: Skin Surface Lipid Collection and Skin Barrier Function

Detailed Description:
This study will be conducted through the use of painless tapes to collect lipid. These will be applied to the skin and removed. Secondly, the barrier function will be evaluated through the use of non-invasive painless devices that measure sebum, skin water loss, and skin hydration.

Study Type : Observational
Actual Enrollment : 41 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Sebum Collection for Analysis and Correlation to Sebum Production, Barrier Function, and With Cutaneous and Internal Inflammatory Disease
Actual Study Start Date : June 27, 2014
Actual Primary Completion Date : February 26, 2016
Actual Study Completion Date : February 26, 2016

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
Young Age - Healthy
These subjects are between the age of 12 and 35 years. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other: Skin Surface Lipid Collection and Skin Barrier Function
All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other Names:
  • lipid profile
  • sebum secretion rate
  • skin water loss
  • skin hydration

Old Age -Healthy
These subjects are 55 years of age and older. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other: Skin Surface Lipid Collection and Skin Barrier Function
All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other Names:
  • lipid profile
  • sebum secretion rate
  • skin water loss
  • skin hydration

Active Smoker
These subjects are active smokers who smoke often. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other: Skin Surface Lipid Collection and Skin Barrier Function
All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other Names:
  • lipid profile
  • sebum secretion rate
  • skin water loss
  • skin hydration

Dermatological skin condition: Acne vulgaris
These subjects have acne vulgaris. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other: Skin Surface Lipid Collection and Skin Barrier Function
All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other Names:
  • lipid profile
  • sebum secretion rate
  • skin water loss
  • skin hydration

Dermatological skin condition: Atopic dermatitis
These subjects have atopic dermatitis. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other: Skin Surface Lipid Collection and Skin Barrier Function
All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other Names:
  • lipid profile
  • sebum secretion rate
  • skin water loss
  • skin hydration




Primary Outcome Measures :
  1. Lipid Profile-aging [ Time Frame: 1 day ]
    The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.

  2. Lipid Profile-acne [ Time Frame: 1 day ]
    The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.

  3. Lipid Profile-atopic dermatitis [ Time Frame: 1 day ]
    The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.

  4. Lipid Profile-smoking [ Time Frame: 1 day ]
    The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.


Secondary Outcome Measures :
  1. Skin Barrier Function- aging [ Time Frame: 1 day ]
    The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.

  2. Skin Barrier Function- acne [ Time Frame: 1 day ]
    The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.

  3. Skin Barrier Function- atopic dermatitis [ Time Frame: 1 day ]
    The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.

  4. Skin Barrier Function- smoking [ Time Frame: 1 day ]
    The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.



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Ages Eligible for Study:   12 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Study patients will be recruited from the UC Davis Department of Dermatology, UC Davis undergraduate campus, Sacramento State University, and from the greater Sacramento area.
Criteria

Inclusion Criteria:

  • Subjects that are 12 years of age or older

Exclusion Criteria:


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03112876


Locations
United States, California
UC Davis Department of Dermatology
Sacramento, California, United States, 95816
Sponsors and Collaborators
University of California, Davis
Investigators
Principal Investigator: Raja K Sivamani, MD UC Davis

Additional Information:
Publications:
Responsible Party: University of California, Davis
ClinicalTrials.gov Identifier: NCT03112876     History of Changes
Other Study ID Numbers: 605131
First Posted: April 13, 2017    Key Record Dates
Last Update Posted: April 13, 2017
Last Verified: April 2017

Keywords provided by University of California, Davis:
younger age
older age
atopic dermatitis
acne
smoker

Additional relevant MeSH terms:
Dermatitis
Dermatitis, Atopic
Eczema
Skin Diseases
Skin Diseases, Genetic
Genetic Diseases, Inborn
Skin Diseases, Eczematous
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases