Evaluation of Fetal Cardiac Function and Vascular Hemodynamics in Intrauterine Growth Restriction
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|ClinicalTrials.gov Identifier: NCT03108040|
Recruitment Status : Completed
First Posted : April 11, 2017
Last Update Posted : February 18, 2020
Intrauterine growth restriction (IUGR) is one of the major contributors to perinatal mortality and morbidity and is characterized by complex hemodynamic changes involving placental and fetal arterial, cardiac and venous circulations .However, the temporal sequence of these modifications in relation to other hemodynamic changes of the fetal arterial and venous circulations is unknown.
The aim of this study was to evaluate cardiac function and other hemodynamic changes in a group of fetuses with IUGR and clinical impact on perinatal outcome .
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||534 participants|
|Official Title:||Evaluation of Non Invasive Fetal Cardiac Functions and Fetal Arterial&Venous Doppler Study in Intrauterine Growth Restriction as Predictive Parameters of Perinatal Outcome|
|Actual Study Start Date :||May 10, 2017|
|Actual Primary Completion Date :||July 10, 2019|
|Actual Study Completion Date :||January 10, 2020|
- Myocardial performance index [ Time Frame: 5 minutes ]Ratio between isovolumetric time to ejection time
- Aortic isthmus flow index [ Time Frame: 5 minutes ]Aortic isthmus flow index = Ratio of (systolic velocity time integral+diastolic velocity time integral) / systolic velocity time integral
- Cerebroplacental ratio [ Time Frame: 5 minutes ]cerebroplacental ratio = Rtio middle cerebral artery pulsatility index / umbilical artery pulsatility index
- Preload Index in inferior vena cava [ Time Frame: 5 minutes ]Preload Index in inferior vena cava = ratio of peak systolic velocity in atrial contraction /peak systolic velocity ventricular systole
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03108040
|Advanced Fetal Cair Unit - Assiut University|