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Sensory-motor Interactions in the Perception of Vowels: a Study in Repetition - Suppression (NEUROPHONE)

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ClinicalTrials.gov Identifier: NCT03102983
Recruitment Status : Recruiting
First Posted : April 6, 2017
Last Update Posted : April 6, 2017
Sponsor:
Collaborator:
Gipsa-Lab, Département Parole et Cognition
Information provided by (Responsible Party):
University Hospital, Grenoble

Brief Summary:
The aim of our study is to show by fMRI the involvement of the motor system in the perception of speech, and more particularly how this implication is modulated by the degree of prototypicity of the stimuli.

Condition or disease Intervention/treatment Phase
Healthy Other: MRI functional Not Applicable

Detailed Description:

Each participant will undergo two visits:

Phase 1: The Gipsa-Lab Laboratory's Department of Speech and Cognition. This first visit will make it possible to make recordings of their vowel productions and to verify that the participants correspond to the criteria necessary for the study (passing the Edinburgh manual laterality test and auditory thresholds checked using a " An audiogram). It will also be an opportunity to provide them with the consent documents and the fact sheet, which will give them time to read it before the MRI exam. The duration of this first visit will be approximately 1 hour.

Phase 2: fMRI review in the 3Tesla MRI Unit at the Grenoble University Hospital Center. Participants will first undergo a medical examination in order to verify their absence of contraindication to the MRI examination. At the end of this medical examination, the consent of participation will be signed. The participants will then be able to carry out the MRI examination for a duration of about 1h15, then the behavioral judgment test of perceptual distance. The total duration of this second visit will be approximately 1h45.


Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 25 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Sensory-motor Interactions in the Perception of Vowels: a Study in Repetition - Suppression
Actual Study Start Date : October 6, 2016
Estimated Primary Completion Date : April 6, 2018
Estimated Study Completion Date : May 6, 2018

Arm Intervention/treatment
Experimental: Healthy Volonteers Other: MRI functional
vowels records and MRI session




Primary Outcome Measures :
  1. Evaluate the involvement of the speech motor system in the perception of vowels, using functional magnetic resonance imaging (fMRI). [ Time Frame: One hour and forty five minutes ]
    fMRI measured



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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Medicall exam before MRI
  • Pregnant Women
  • Patients aged 18-45 years, Right-handed
  • without neurologic and/or psychiatric troubles
  • normal audition
  • Audition normale
  • French mother tongue
  • Social security affiliation

Exclusion Criteria:

  • protected person
  • MRI contraindication
  • claustrophobia
  • respirtaory and cardiovascular pathology
  • toxic substances taking

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03102983


Contacts
Contact: Marjorie DOLE, PhD marjorie.dole-faress@gipsa-lab.fr
Contact: Coriandre VILAIN, PhD coriandre.vilain@gipsa-lab.fr

Locations
France
CHU Grenoble-Alpes Recruiting
Grenoble, Isère, France, 38043
Contact: Marjorie DOLE, phd         
Sponsors and Collaborators
University Hospital, Grenoble
Gipsa-Lab, Département Parole et Cognition
Investigators
Principal Investigator: Alexandre KRAINIK, PhD University Hospital, Grenoble

Responsible Party: University Hospital, Grenoble
ClinicalTrials.gov Identifier: NCT03102983     History of Changes
Other Study ID Numbers: 38RC16.026
First Posted: April 6, 2017    Key Record Dates
Last Update Posted: April 6, 2017
Last Verified: March 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by University Hospital, Grenoble:
MRI, Functional