Reducing the Duration of Untreated Psychosis (ReduceDUP)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT03102151
Recruitment Status : Recruiting
First Posted : April 5, 2017
Last Update Posted : April 5, 2017
University of California, Los Angeles
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
Steven Lopez, University of Southern California

Brief Summary:
The study examines the possible effect of a community campaign to decrease the duration of untreated psychosis in persons with their first episode of a psychotic disorder.

Condition or disease Intervention/treatment
First Episode Psychosis Other: Community Campaign La CLAVE

Detailed Description:
The study examines whether a community campaign can reduce over time the duration of untreated psychosis (DUP) among persons with first episode psychosis (FEP). The DUP of mental health patients with FEP who sought services at a public outpatient or an inpatient facility was assessed for a 15 month period prior to the campaign launch. This serves as the baseline or historical control. The DUP will continue to be assessed for another 3 years. The hypothesis being tested is that there will be a significant decrease in DUP between baseline, one-year, two-year and three-year follow-ups. This study is being carried out with Latinos in Los Angeles County because as a group, particularly among Spanish-speaking immigrants, Latinos are at high risk for prolonged DUP.

Study Type : Observational
Estimated Enrollment : 145 participants
Observational Model: Ecologic or Community
Time Perspective: Prospective
Official Title: Reducing the Duration of Untreated Psychosis Through Community Education
Study Start Date : May 2014
Estimated Primary Completion Date : August 2018
Estimated Study Completion Date : September 2018

Resource links provided by the National Library of Medicine

Intervention Details:
  • Other: Community Campaign La CLAVE
    A community campaign to teach community residents and professional networks the signs and symptoms of psychosis using social media, community talks, and advertising.

Primary Outcome Measures :
  1. Latency to Treatment (LTT) a novel interview based assessment tool to measure the Duration of Untreated Psychosis [ Time Frame: At the time of recruitment into the study ]
    The time from the onset of psychosis to the time the subject receives appropriate mental health treatment. The metric is number of weeks that the person went without treatment from illness onset. The number of weeks is the variable of interest that will be aggregated.

Secondary Outcome Measures :
  1. Psychosis literacy, a questionnaire based inquiry for which the respondents answer either open-ended questions (e.g., What is serious mental Illness?) or "Yes-no" questions ("e.g., Can you recognize a serious mental illness in others?) [ Time Frame: At the time of recruitment in to study ]
    The responses to the interview are either written down or audio-recorded. Raters then listen or read the responses and code them. The responses are aggregated as frequencies (e.g., the number of symptoms identified) or as percentages (e.g., the proportion of respondents who reported that they can recognize a serious mental illness in others).

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   15 Years to 65 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Living in the catchment area of San Fernando Mental Health Outpatient clinic, a clinic with the Los Angeles County Department of Mental Health

Inclusion Criteria:

  • Meet Diagnostic and Statistical Manual-4 criteria for a psychotic disorder
  • of Latino origin

Exclusion Criteria:

  • has a neurological disorder or suffers from brain trauma

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT03102151

Contact: Steven Lopez, PhD 213 740-6310
Contact: Alex Kopelowicz, MD

United States, California
San Fernando Mental Health Center Recruiting
Granada Hills, California, United States, 91344
Contact: Alex Kopelowicz, MD   
Sponsors and Collaborators
University of Southern California
University of California, Los Angeles
National Institute of Mental Health (NIMH)
Principal Investigator: Steven Lopez, PhD University of Southern California

Responsible Party: Steven Lopez, Professor, University of Southern California Identifier: NCT03102151     History of Changes
Other Study ID Numbers: USCLaCLAVE
1R01MH103830 ( U.S. NIH Grant/Contract )
First Posted: April 5, 2017    Key Record Dates
Last Update Posted: April 5, 2017
Last Verified: March 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Additional relevant MeSH terms:
Psychotic Disorders
Mental Disorders
Schizophrenia Spectrum and Other Psychotic Disorders