Neuroplasticity in an Extended Amygdala Network as a Target Mechanism for Attention Bias Modification Outcome
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|ClinicalTrials.gov Identifier: NCT03092609|
Recruitment Status : Recruiting
First Posted : March 28, 2017
Last Update Posted : March 29, 2018
|Condition or disease||Intervention/treatment||Phase|
|Anxiety||Behavioral: Attention Bias Modification Behavioral: Attention Control||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||100 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Neuroplasticity in an Extended Amygdala Network as a Target Mechanism for Attention Bias Modification Outcome|
|Actual Study Start Date :||December 15, 2017|
|Estimated Primary Completion Date :||September 14, 2020|
|Estimated Study Completion Date :||September 14, 2020|
|Experimental: Attention Bias Modification||
Behavioral: Attention Bias Modification
Attention bias modification (ABM) sessions will consist of a modified dot-probe task that only contains incongruent trials (i.e., target-dot - neutral stimulus 100% pairing).
|Active Comparator: Attention Control||
Behavioral: Attention Control
Attention control (AC) sessions, will consist of a standard dot-probe task (i.e., target-dot - neutral/threat stimulus 50% pairing). Thus, for AC participants, bias should remain the same, while ABM participants should show a reduced bias to threat.
- Attentional Bias [ Time Frame: Baseline and after 6 weeks of the intervention ]Reaction time difference to congruent and incongruent trials in the dot-probe task, which measure heightened attentional bias to threat.
- State and Trait Anxiety [ Time Frame: Baseline and after 6 weeks of the intervention ]Anxiety as measured by the Speilberger State-Trait Anxiety Inventory
- MRI measures of gray matter volume [ Time Frame: Baseline and after 6 weeks of the intervention ]T1-weighted MRI measures of gray matter volume
- MRI measures of structural and functional connectivity [ Time Frame: Baseline and after 6 weeks of the intervention ]Diffusion-tensor weighted MRI based measures of structural connectivity and functional MRI based measures of functional connectivity.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03092609
|Contact: Lin Fang, PhDfirstname.lastname@example.org|
|United States, Michigan|
|Northern Michigan University||Recruiting|
|Marquette, Michigan, United States, 49855|
|Contact: Lin Fang, PhD 906-227-2954 email@example.com|
|Principal Investigator:||Joshua M Carlson, PhD||Northern Michigan University|