Inspiratory Muscle Training in Chronic Kidney Disease
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|ClinicalTrials.gov Identifier: NCT03082404|
Recruitment Status : Not yet recruiting
First Posted : March 17, 2017
Last Update Posted : March 17, 2017
|Condition or disease||Intervention/treatment||Phase|
|Chronic Kidney Disease||Other: Inspiratory muscle training||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||25 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Official Title:||Effects of High-intensity Inspiratory Muscle Training in Chronic Kidney Disease: Randomized Clinical Trial|
|Estimated Study Start Date :||April 3, 2017|
|Estimated Primary Completion Date :||May 2, 2017|
|Estimated Study Completion Date :||June 2, 2017|
Experimental: Inspiratory muscle training group
Six times a week (three supervised at hemodialysis unit and other three times at home), 5 series, 10 repetitions, two-minutes interval or according to the patient tolerance.
Other: Inspiratory muscle training
Inspiratory muscle training will be performed during the first hour of hemodialysis treatment and the protocol will consist of five series with 10 repetitions, each series with a two-minute interval of according to patient tolerance. The overload will be adjusted weekly, beginning with 50% of the maximum inspiratory pressure, during the first week, 60% of maximum inspiratory pressure in the second and third week and 70% of maximum inspiratory pressure in the fourth and fifth weeks. Maximum inspiratory pressure will be evaluated before the protocol period and adjusted weekly by manovacuometry.
Other Name: High intensity inspiratory muscle training
No Intervention: Control group
The patients in this group will be evaluated at baseline and reassessed after five weeks of follow-up.
- Functional capacity [ Time Frame: Five weeks ]Functional capacity will be assessed by the distance walked in six-minute walk test (6MWT)
- Muscle strength of inspiratory muscle [ Time Frame: Five weeks ]Muscle strength will be assessed by manovacuometry
- Proximal strength of lower limbs [ Time Frame: Five weeks ]Proximal strength of lower limbs will be assessed by the number of repetitions performed in sit-and-stand test (SST).
- Endothelial function [ Time Frame: Five weeks ]Endothelial function will be assessed by flow mediated dilation technique
- Quality of Life [ Time Frame: Five weeks ]The quality of life will be assessed by questionnaire Kidney Disease and Quality-of-Life Short-Form (KDQOL-SFTM)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03082404
|Contact: Rodrigo DM Plentz, PhD||(+55) firstname.lastname@example.org|
|Contact: Rodrigo DM Plentz, PhD||(+55) email@example.com|
|Principal Investigator:||Rodrigo DM Plentz, PhD||Federal University of Health Sciences of Porto Alegre|