Gingival Bleeding and Von Willebrand Disease Typ 2 and 3
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|ClinicalTrials.gov Identifier: NCT03078595|
Recruitment Status : Completed
First Posted : March 13, 2017
Last Update Posted : August 22, 2017
|Condition or disease|
|Gingival Bleeding Von Willebrand Diseases|
Show Detailed Description
|Study Type :||Observational|
|Actual Enrollment :||48 participants|
|Official Title:||Is Gingival Bleeding a Symptom of Patients With Type 2 and 3 Von Willebrand Disease? A Case-Control Study|
|Actual Study Start Date :||July 16, 2015|
|Actual Primary Completion Date :||April 4, 2017|
|Actual Study Completion Date :||April 4, 2017|
von Willebrand disease type 2 and 3
Examinations (haematologically and periodontally) of von Willebrand disease patients with type 2 and 3 and healthy controls to evaluate whether type 2 and 3 VWD determines an increased susceptibility to gingival bleeding in response to the oral biofilm
For each case (VWD) a respective haematologically healthy control is recruited from the gingivitis and periodontitis patients of the Department of Periodontology, Centre for Dentistry and Oral Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt/Main. Each control is matched to one of the respective cases for sex, age (±5 years), self-reported smoking status (current smoker/non-smoker), number of remaining teeth (±2 teeth), and periodontal diagnosis (gingivitis, chronic or aggressive periodontitis).
- Gingival Bleeding Index (GBI) [ Time Frame: cross-sectional: only one assessment ]A periodontal probe is gently moved through the gingival sulcus. Bleeding is assessed at 6 sites per tooth (mesio-buccal, buccal, disto-buccal, disto-oral, oral, mesio-oral). The frequency of bleeding sites of the total number of assessed sites is calculated as index.
- Bleeding on Probing (BOP) [ Time Frame: cross-sectional: only one assessment ]Using a periodontal probe probing pocket depths (PPD) are assessed with a force of 0.2 N at 6 sites per tooth (mesio-buccal, buccal, disto-buccal, disto-oral, oral, mesio-oral). After 30 seconds bleeding on probing is scored at each site. The frequency of bleeding sites of the total number of assessed sites is calculated as index.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03078595
|Center for Dentistry and Oral Medicine (Carolinum), Johann Wolfgang Goethe-University|
|Frankfurt am Main, Hessen, Germany, 60596|
|Dept. of Periodontology, Center of Dentistry and Oral Medicine, Johann Wolfgang Goethe-University|
|Frankfurt am Main, Germany, 60590|