Homeostatic and Non-homeostatic Processing of Food Cues in Anorexia Nervosa
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|ClinicalTrials.gov Identifier: NCT03075371|
Recruitment Status : Recruiting
First Posted : March 9, 2017
Last Update Posted : October 27, 2017
|Condition or disease||Intervention/treatment||Phase|
|Anorexia Nervosa Healthy||Other: Glucose Other: Placebo||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||25 participants|
|Intervention Model:||Crossover Assignment|
|Primary Purpose:||Basic Science|
|Official Title:||Homeostatic and Non-homeostatic Processing of Food Cues in Anorexia Nervosa|
|Actual Study Start Date :||September 2014|
|Estimated Primary Completion Date :||December 2017|
|Estimated Study Completion Date :||February 2018|
|Active Comparator: intragastric glucose administration||
75 g of glucose dissolved in 300 ml of water
|Placebo Comparator: intragastric water administration||
300 ml of tap water
- Resting state brain activity using fMRI [ Time Frame: 35 min ]Functional brain imaging will be employed to assess metabolic gut-brain signaling during a single blind, randomized cross-over design of gastric glucose vs. water infusion.
- Experimental fMRI task [ Time Frame: 20 min ]Participants will be asked to either view food or nonfood images or to down-regulate their emotional response by distracting themselves from the stimuli by solving an arithmetic task.
- Analysis of hormonal satiety signaling [ Time Frame: 30 min before scanning, 30 min after intragastric feeding, 60 min after intragastric feeding ]Blood is collected for the measurement of peripheral ghrelin. In total, three blood samples will be collected.
- Self-report questionnaire regarding eating behavior (Dutch Eating Behavior Questionnaire) [ Time Frame: 30 min ]Psychometric tests will be employed to assess eating behavior and eating disorder psychopathology (using the Dutch Eating Behavior Questionnaire).
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03075371
|Contact: Joe Simon, Dr. Dipl. Psych.||+49 (0)6221 firstname.lastname@example.org|
|University Hospital Heidelberg||Recruiting|
|Contact: Joe Simon, Dr. Dipl. Psych. email@example.com|
|Principal Investigator:||Joe Simon, Dr. Dipl. Psych.||University Hospital Heidelberg|