Homeostatic and Non-homeostatic Processing of Food Cues in Anorexia Nervosa
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|ClinicalTrials.gov Identifier: NCT03075371|
Recruitment Status : Completed
First Posted : March 9, 2017
Last Update Posted : October 3, 2019
|Condition or disease||Intervention/treatment||Phase|
|Anorexia Nervosa Healthy||Other: Glucose Other: Placebo||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||85 participants|
|Intervention Model:||Crossover Assignment|
|Primary Purpose:||Basic Science|
|Official Title:||Homeostatic and Non-homeostatic Processing of Food Cues in Anorexia Nervosa|
|Actual Study Start Date :||September 2014|
|Actual Primary Completion Date :||December 2018|
|Actual Study Completion Date :||February 2019|
|Active Comparator: intragastric glucose administration||
75 g of glucose dissolved in 300 ml of water
|Placebo Comparator: intragastric water administration||
300 ml of tap water
- Resting state brain activity using fMRI [ Time Frame: 35 min ]Functional brain imaging will be employed to assess metabolic gut-brain signaling during a single blind, randomized cross-over design of gastric glucose vs. water infusion.
- Experimental fMRI task [ Time Frame: 20 min ]Participants will be asked to either view food or nonfood images or to down-regulate their emotional response by distracting themselves from the stimuli by solving an arithmetic task.
- Analysis of hormonal satiety signaling [ Time Frame: 30 min before scanning, 30 min after intragastric feeding, 60 min after intragastric feeding ]Blood is collected for the measurement of peripheral ghrelin. In total, three blood samples will be collected.
- Self-report questionnaire regarding eating behavior (Dutch Eating Behavior Questionnaire) [ Time Frame: 30 min ]Psychometric tests will be employed to assess eating behavior and eating disorder psychopathology (using the Dutch Eating Behavior Questionnaire).
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03075371
|University Hospital Heidelberg|
|Principal Investigator:||Joe Simon, Dr. Dipl. Psych.||University Hospital Heidelberg|