A Study to Quantify Tumour Perfusion for Spine Metastasis Treated With Stereotactic Body Radiotherapy (SBRT)
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ClinicalTrials.gov Identifier: NCT03072979
Recruitment Status : Unknown
Verified March 2017 by Radiation Oncology, National University Hospital, Singapore. Recruitment status was: Recruiting
First Posted : March 8, 2017
Last Update Posted : March 8, 2017
National University Hospital, Singapore
National University, Singapore
Information provided by (Responsible Party):
Radiation Oncology, National University Hospital, Singapore
Pre-clinical evidence suggests that radiotherapy reduces tumour-associated vasculature. The investigators will conduct a single-arm prospective study to quantify the reduction in tumour vasculature post-radiotherapy
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Layout table for eligibility information
Ages Eligible for Study:
21 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
A total of 18 patients from National University Hospital (NUH) will be enrolled. Informed consent will be taken from patients prior to trial entry at NUH.
Age ≥21 years of age
Proven metastatic disease, excluding haematological and germ cell neoplasms
Life expectancy >3 months, Eastern Cooperative Oncology group (ECOG) 0-2
The patient must not have an allergy to gadolinium contrast that will limit the ability to image the tumour by MRI safely even with the use of premedication
eGFR < 30 mL/min or if patient is suffering from acute renal insufficiency
Prior radiotherapy to the specified region
Recent surgery to affected spinal levels, or patients requiring immediate surgical intervention
Spinal instability score (SINS) >12
Symptomatic cord compression (Bilksy grade 2 or 3), or worsening neurological deficits