Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing (GENEPIC)
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ClinicalTrials.gov Identifier: NCT03065686 |
Recruitment Status :
Recruiting
First Posted : February 28, 2017
Last Update Posted : March 4, 2021
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Cleft Lip and Palate | Genetic: identification of genetic factors | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 30 participants |
Allocation: | N/A |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Basic Science |
Official Title: | Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing GENEPIC |
Actual Study Start Date : | November 30, 2016 |
Estimated Primary Completion Date : | November 30, 2022 |
Estimated Study Completion Date : | November 30, 2022 |

Arm | Intervention/treatment |
---|---|
Experimental: Identification of genetic factors
Clinical questionnaire and analysis of genetic data obtained by exome high-throughput sequencing
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Genetic: identification of genetic factors
Clinical questionnaire and analysis of genetic data obtained by exome high-throughput sequencing |
- Identification of genetic factors [ Time Frame: Day 1 ]Identification of genetic factors implicated in orofacial cleft using whole exome sequencing (WES).

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Ages Eligible for Study: | Child, Adult, Older Adult |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Subject with a NSCL/P or CL/P of unknown etiology,
- national health care insurance holders
Exclusion Criteria:
- Subject with a CL/P of known etiology,
- Subject with a NSCL/P and an IRF6 mutation

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03065686
Contact: Bénédicte DEMEER, MD | +33 3 22 08 75 81 | demeer.benedicte@chu-amiens.fr |
France | |
CHU Amiens Picardie | Recruiting |
Amiens, France, 80054 | |
Contact: Bénédicte DEMEER, MD +33 3 22 08 75 81 demeer.benedicte@chu-amiens.fr |
Principal Investigator: | Bénédicte DEMEER, MD | CHU Amiens |
Responsible Party: | Centre Hospitalier Universitaire, Amiens |
ClinicalTrials.gov Identifier: | NCT03065686 |
Other Study ID Numbers: |
PI2015_843_0016 |
First Posted: | February 28, 2017 Key Record Dates |
Last Update Posted: | March 4, 2021 |
Last Verified: | March 2021 |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
Cleft Lip and Palate CL/P WES |
Cleft Lip Lip Diseases Mouth Diseases Stomatognathic Diseases |
Mouth Abnormalities Stomatognathic System Abnormalities Congenital Abnormalities |