Turmeric and Turmeric-containing Tablets and Sebum Production
|Skin Inflammation||Dietary Supplement: Turmeric Dietary Supplement: Turmeric-containing combination tablet Dietary Supplement: Placebo tablets|
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
|Official Title:||Pilot Study on the Effects of Oral Turmeric and Turmeric-containing Tablets on Sebum Production|
- Change in facial Sebum production at 4 weeks [ Time Frame: 4 weeks ]The investigators will use Sebutapes placed on the forehead to measure facial sebum production for 60 minutes at baseline and after 4 weeks. The tapes will collect the facial sebum produced during that time.
- Change from baseline in sebum profile, such as inflammatory markers, at 4 weeks [ Time Frame: 4 weeks ]
|Study Start Date:||November 2016|
|Estimated Study Completion Date:||October 23, 2017|
|Estimated Primary Completion Date:||October 23, 2017 (Final data collection date for primary outcome measure)|
Active Comparator: Turmeric group
2,000 mg turmeric per day - supplied by Banyan® Botanicals )
o Each tablet contains 500 mg of Turmeric (Curcuma longa). Subjects will take 2 tablets twice per day, with a total daily dose of 2,000 mg.
|Dietary Supplement: Turmeric|
Active Comparator: Turmeric-containing combination tablets
• 2,000 mg Healthy Skin™ Tablets, contains:
|Dietary Supplement: Turmeric-containing combination tablet|
Placebo Comparator: Placebo tablets group
||Dietary Supplement: Placebo tablets|
Turmeric (Curcuma longa) is a spice that has been shown to exhibit anti-inflammatory, antimicrobial, antioxidant, anti-neoplastic properties, and even potential to improve mental illnesses. In western herbalism, Turmeric is primarily used as an anti-inflammatory agent. In India, turmeric is used in Ayurevdic medicine for the treatment of acne. It has been used both internally and externally.
Curcumin is a phytochemical derived from turmeric and believed to be one of the key active components of turmeric. Curcumin is reported to have activity as an antibacterial and anti-inflammatory agent and has been used as a paste for skin eruptions and infections. Previous basic science work by Dr. Raja Sivamani's lab has shown that both turmeric and curcumin inhibit lipid synthesis in human sebocytes, the cells responsible for the production of sebum
The goal of this study is to evaluate how ingestion of turmeric and tablets that have a combination of herbs including turmeric may modulate sebum production.
Please refer to this study by its ClinicalTrials.gov identifier: NCT03065504
|Contact: Alexandra R Vaughn, B.S.||firstname.lastname@example.org|
|United States, California|
|University of California, Davis Dermatology Clinical Trials Unit||Recruiting|
|Sacramento, California, United States, 95816|
|Contact: Manisha Notay, MBBS 916-734-6550 email@example.com|
|Principal Investigator: Raja Sivamani, MD MS CAT|
|Principal Investigator:||Raja K Sivamani, M.D.||University of California, Davis|