Turmeric and Turmeric-containing Tablets and Sebum Production
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|ClinicalTrials.gov Identifier: NCT03065504|
Recruitment Status : Active, not recruiting
First Posted : February 28, 2017
Last Update Posted : November 7, 2017
|Condition or disease||Intervention/treatment||Phase|
|Skin Inflammation||Dietary Supplement: Turmeric Dietary Supplement: Turmeric-containing combination tablet Dietary Supplement: Placebo tablets||Not Applicable|
Turmeric (Curcuma longa) is a spice that has been shown to exhibit anti-inflammatory, antimicrobial, antioxidant, anti-neoplastic properties, and even potential to improve mental illnesses. In western herbalism, Turmeric is primarily used as an anti-inflammatory agent. In India, turmeric is used in Ayurevdic medicine for the treatment of acne. It has been used both internally and externally.
Curcumin is a phytochemical derived from turmeric and believed to be one of the key active components of turmeric. Curcumin is reported to have activity as an antibacterial and anti-inflammatory agent and has been used as a paste for skin eruptions and infections. Previous basic science work by Dr. Raja Sivamani's lab has shown that both turmeric and curcumin inhibit lipid synthesis in human sebocytes, the cells responsible for the production of sebum
The goal of this study is to evaluate how ingestion of turmeric and tablets that have a combination of herbs including turmeric may modulate sebum production.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||30 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Participant, Investigator, Outcomes Assessor)|
|Primary Purpose:||Basic Science|
|Official Title:||Pilot Study on the Effects of Oral Turmeric and Turmeric-containing Tablets on Sebum Production|
|Study Start Date :||November 2016|
|Actual Primary Completion Date :||October 23, 2017|
|Estimated Study Completion Date :||September 4, 2018|
Active Comparator: Turmeric group
2,000 mg turmeric per day - supplied by Banyan® Botanicals )
o Each tablet contains 500 mg of Turmeric (Curcuma longa). Subjects will take 2 tablets twice per day, with a total daily dose of 2,000 mg.
|Dietary Supplement: Turmeric|
Active Comparator: Turmeric-containing combination tablets
• 2,000 mg Healthy Skin™ Tablets, contains:
|Dietary Supplement: Turmeric-containing combination tablet|
Placebo Comparator: Placebo tablets group
||Dietary Supplement: Placebo tablets|
- Change in facial Sebum production at 4 weeks [ Time Frame: 4 weeks ]The investigators will use Sebutapes placed on the forehead to measure facial sebum production for 60 minutes at baseline and after 4 weeks. The tapes will collect the facial sebum produced during that time.
- Change from baseline in sebum profile, such as inflammatory markers, at 4 weeks [ Time Frame: 4 weeks ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03065504
|United States, California|
|University of California, Davis Dermatology Clinical Trials Unit|
|Sacramento, California, United States, 95816|
|Principal Investigator:||Raja K Sivamani, M.D.||University of California, Davis|