EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved)
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT03057951 |
Recruitment Status :
Completed
First Posted : February 20, 2017
Results First Posted : June 6, 2022
Last Update Posted : June 6, 2022
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This is a study in adults with chronic heart failure. People with chronic heart failure may need to be hospitalised for their condition. Some people with chronic heart failure may eventually die from their condition. The purpose of the study is to find out whether a medicine called empagliflozin lowers the chances of patients having to go to hospital for heart failure and whether it improves their survival. The study is open to patients with a type of chronic heart failure called chronic heart failure with preserved ejection fraction.
Participants stay in the study until researchers have enough information about how effective empagliflozin is. It is expected that participants who enter at the very beginning of the enrolment period may be in the study for over 3 years, while participants who enter near the end of the enrolment period may be in the study for less than 2 years. The participants are put into 2 groups. It is decided by chance who gets into which group. One group gets empagliflozin tablets every day and the other group gets placebo tablets every day. Placebo tablets look like empagliflozin tablets but contain no medicine.
Participants visit the doctors regularly. During these visits, the doctors collect information about the participant's health. The doctors want to know how many patients had to go to hospital because of heart failure or who died from cardiovascular disease.
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Heart Failure | Drug: Empagliflozin Drug: Placebo | Phase 3 |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 5988 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double (Participant, Investigator) |
Primary Purpose: | Treatment |
Official Title: | A Phase III Randomised, Double-blind Trial to Evaluate Efficacy and Safety of Once Daily Empagliflozin 10 mg Compared to Placebo, in Patients With Chronic Heart Failure With Preserved Ejection Fraction (HFpEF) |
Actual Study Start Date : | March 2, 2017 |
Actual Primary Completion Date : | April 26, 2021 |
Actual Study Completion Date : | April 26, 2021 |

Arm | Intervention/treatment |
---|---|
Experimental: 10 mg Empagliflozin |
Drug: Empagliflozin
once daily
Other Name: JARDIANCE, JARDIANZ, GIBTULIO |
Placebo Comparator: Placebo |
Drug: Placebo
once daily |
- Time to First Event of Adjudicated Cardiovascular (CV) Death or Adjudicated Hospitalisation for Heart Failure (HHF) [ Time Frame: From randomization until completion of the planned treatment phase, up to 1403 days. ]
Failure with preserved Ejection Fraction (HFpEF). The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].
Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
- Occurrence of Adjudicated Hospitalisation for Heart Failure (HHF) (First and Recurrent) [ Time Frame: From randomization until completion of the planned treatment phase, up to 1403 days. ]Reported is the total number of adjudicated HHF events (first and recurrent) which occurred.
- eGFR (CKD-EPI) cr Slope of Change From Baseline [ Time Frame: At baseline, week 4, 12, 32, 52, 76, 100, 124, 148, 172 and week 196, up to 1043 days. ]
Glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula with serum creatinine measurement (eGFR(CKD-EPI)cr) slope of change from baseline.
Available on-treatment change-from-baseline data were used. The slope represents the long term effect of eGFR change from baseline and provides the yearly rate of decline.
Timepoints after baseline were included in calculation of slope of change from baseline.
The slope per patient was calculated using a random coefficient model with terms for treatment, region, baseline status of diabetes, age, sex, left ventricular ejection fraction (LVEF) and glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula (eGFR (CKD-EPI)cr) at baseline and in addition the factors "time", "treatment-by-time interaction", and "baseline eGFR (CKD-EPI)cr-by-time interaction".
- Time to the First Event in the Composite Renal Endpoint: Chronic Dialysis, Renal Transplant, or Sustained Reduction in eGFR (CKD-EPI)cr [ Time Frame: From randomization until completion of the planned treatment phase, up to 1403 days. ]
Chronic dialysis was defined as dialysis with a frequency of twice per week or more for at least 90 days.
Sustained was determined by two or more consecutive post-baseline central laboratory measurement separated by at least 30 days.
Reduction in glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula with serum creatinine measurement (eGFR (CKD-EPI)cr) was defined as reduction in eGFR from baseline ≥40%, eGFR <15 mL/min/1.73 m^2 for patients with baseline eGFR ≥30 mL/min/1.73 m^2, or eGFR <10 mL/min/1.73 m^2 for patients with baseline eGFR <30 mL/min/1.73 m^2.
The incidence rate per 100 patient years (100 * number of patients with event / time at risk [years]) is reported. Time at risk [year] is calculated as: Sum of time at risk [days] over all patients in a treatment group / 365.25.
Abbreviation:
Patient-years (pt-yrs).
- Time to First Adjudicated Hospitalisation for Heart Failure (HHF) [ Time Frame: From randomization until completion of the planned treatment phase, up to 1403 days. ]
Time to first adjudicated HHF. The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].
Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
- Time to Adjudicated Cardiovascular (CV) Death [ Time Frame: From randomization until completion of the planned treatment phase, up to 1403 days. ]
Time to adjudicated CV death. The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].
Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
- Time to All-cause Mortality [ Time Frame: From randomization until completion of the planned treatment phase, up to 1403 days. ]
Time to all-cause mortality. The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].
Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
- Time to Onset of Diabetes Mellitus (DM) in Patients With Pre-DM [ Time Frame: From randomization until completion of the planned treatment phase, to 1403 days. ]
Time to onset of DM (defined as HbA1c ≥6.5% or as diagnosed by the investigator) in patients with pre-DM.
Pre-DM was defined as no history of DM and no HbA1c ≥6.5% before treatment, and a pre-treatment HbA1c value of ≥5.7% and <6.5%.
The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].
Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
- Change From Baseline in Kansas City Cardiomyopathy Questionaire (KCCQ) Clinical Summary Score at Week 52 [ Time Frame: At baseline and at week 12, week 32 and week 52. ]
The KCCQ is a 23-item self-administered questionnaire designed to evaluate physical limitations, symptoms (frequency, severity, and changes over time), social limitations, self-efficacy, and quality of life in patients with Heart Failure. The KCCQ-clinical summary score comprises the following domains: Symptom frequency, symptom burden and physical limitation. The score is calculated by summing domain responses and then transforming scores to a 0-100 unit scale with higher scores indicating better health status.
For patients who died, a worst score (score of 0) was imputed for the score at all subsequent scheduled visits after the date of death where the score would have been assessed.
Change from baseline in KCCQ-score at week 52 was modeled using a MMRM with visit (week 12, 32 and 52) as repeated measures, adjusted mean (standard error) at week 52 is reported.
- Occurrence of All-cause Hospitalisation (First and Recurrent) [ Time Frame: From randomization until completion of the planned treatment phase, up to 1403 days. ]Occurrence of all-cause hospitalisation (first and recurrent). Total number of all cause hospitalisations is reported.

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion criteria:
- Male or female patient, age >= 18 years at screening. For Japan only: Age >=20 years at screening
- Patients with chronic HF (Chronic Heart Failure) NYHA (New York Heart Association classification) class II-IV and preserved EF (Ejection Fraction)(LVEF (Left Ventricular Ejection Fraction) > 40 %) and elevated NT-proBNP (N-terminal of the prohormone brain natriuretic peptide) > 300 pg/ml for patients without AF, OR > 900 pg/ml for patients with AF, analysed at the Central laboratory at Visit 1
- Structural heart disease within 6 months prior to Visit 1, OR documented HHF (Hospitalisation for Heart Failure) within 12 months prior to Visit 1
- Stable dose of oral diuretics, if prescribed
- Signed and dated written ICF (informed consent form)
- Further inclusion criteria apply
Exclusion criteria:
- Myocardial infarction, coronary artery bypass graft surgery or other major cardiovascular surgery, stroke or TIA (Transient Ischaemic Attack) in past 90 days prior to Visit 1
- Heart transplant recipient or listed for heart transplant
- Acute decompensated HF (Heart Failure)
- Systolic blood pressure (SBP) >= 180 mmHg at Visit 2.
- Symptomatic hypotension and/or a SBP < 100 mmHg
- Indication of liver disease,
- Impaired renal function, defined as eGFR (Estimated Glomerular Filtration Rate) < 20 mL/min/1.73 m2 (CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration Equation))cr or requiring dialysis
- History of ketoacidosis
- Current use or prior use of a SGLT (Sodium-glucose co-transporter) -2 inhibitor or combined SGLT-1 and 2 inhibitor
- Currently enrolled in another investigational device or drug trial
- Known allergy or hypersensitivity to empagliflozin or other SGLT-2 inhibitors
- Women who are pregnant, nursing, or who plan to become pregnant while in the trial
- Further exclusion criteria may apply

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03057951


United States, Alabama | |
Pinnacle Research Group, LLC | |
Anniston, Alabama, United States, 36207 | |
University of Alabama at Birmingham | |
Birmingham, Alabama, United States, 35249 | |
Heart Center Research, LLC | |
Huntsville, Alabama, United States, 35801 | |
United States, California | |
University of California San Francisco | |
Fresno, California, United States, 93701 | |
La Mesa Cardiac Center | |
La Mesa, California, United States, 91942 | |
Purushotham, Akther & Roshan Kotha, MD Inc. | |
La Mesa, California, United States, 91942 | |
Long Beach Center for Clinical Research | |
Long Beach, California, United States, 90807 | |
VA Greater Los Angeles Healthcare System | |
Los Angeles, California, United States, 90073 | |
Merced Vein and Vascular Center | |
Merced, California, United States, 95340 | |
Valley Clinical Trials, Inc. | |
Northridge, California, United States, 91325 | |
University of California Irvine | |
Orange, California, United States, 92865 | |
Covigilant Research, LLC | |
Riverside, California, United States, 92506 | |
University of California San Francisco | |
San Francisco, California, United States, 94143 | |
University of California | |
Torrance, California, United States, 90502 | |
Orange County Research Center | |
Tustin, California, United States, 92780 | |
Blue Coast Cardiology | |
Vista, California, United States, 92083 | |
United States, Colorado | |
South Denver Cardiology Associates, PC | |
Littleton, Colorado, United States, 80120 | |
United States, Florida | |
Integrated Heart Care | |
Boca Raton, Florida, United States, 33434 | |
Southeast Clinical Research, LLC | |
Chiefland, Florida, United States, 32626 | |
Morton Plant Mease Health Care | |
Clearwater, Florida, United States, 33756 | |
Accel Research Sites | |
DeLand, Florida, United States, 32720 | |
Integrative Research Associates | |
Fort Lauderdale, Florida, United States, 33312 | |
Nature Coast Clinical Research | |
Inverness, Florida, United States, 34452 | |
East Coast Institute for Research, LLC | |
Jacksonville, Florida, United States, 32216 | |
Jacksonville Center for Clinical Research | |
Jacksonville, Florida, United States, 32216 | |
Elite Clinical Research | |
Miami, Florida, United States, 33144 | |
Cardiovascular Research Center of South Florida | |
Miami, Florida, United States, 33173 | |
Orlando Health Inc. | |
Orlando, Florida, United States, 32806 | |
Peninsula Research, Inc. | |
Ormond Beach, Florida, United States, 32174 | |
Clearwater Cardiovascular Consultants | |
Safety Harbor, Florida, United States, 34695 | |
Sarasota Memorial Hospital | |
Sarasota, Florida, United States, 34239 | |
University of South Florida | |
Tampa, Florida, United States, 33606 | |
Advent Health Medical Group | |
Tampa, Florida, United States, 33613 | |
United States, Georgia | |
Grady Clinical Research Center | |
Atlanta, Georgia, United States, 30303 | |
Columbus Regional Research Institute | |
Columbus, Georgia, United States, 31904 | |
Cardiovascular Group PC | |
Lawrenceville, Georgia, United States, 30046 | |
Meridian Clinical Research, LLC | |
Savannah, Georgia, United States, 31406 | |
Atlanta Heart Specialists, LLC | |
Tucker, Georgia, United States, 30084 | |
United States, Illinois | |
Northwest Heart Clinical Research, LLC | |
Arlington Heights, Illinois, United States, 60005 | |
Mount Sinai Hospital | |
Chicago, Illinois, United States, 60608 | |
Advocate Health and Hospitals Corporation | |
Naperville, Illinois, United States, 60540 | |
Captain James A. Lovell Federal Health Care Center | |
North Chicago, Illinois, United States, 60064 | |
Rockford Cardiovascular Associates | |
Rockford, Illinois, United States, 61107 | |
United States, Indiana | |
Midwest Cardiovascular Research and Education Foundation | |
Elkhart, Indiana, United States, 46514 | |
St. Francis Medical Group-Indiana Heart Physicians, Inc | |
Indianapolis, Indiana, United States, 46237 | |
Reid Hospital | |
Richmond, Indiana, United States, 47374 | |
Beacon Medical Group Clinical Research | |
South Bend, Indiana, United States, 46601 | |
United States, Iowa | |
Iowa Heart Center | |
Des Moines, Iowa, United States, 50314 | |
United States, Kentucky | |
Norton Heart Specialists | |
Louisville, Kentucky, United States, 40202 | |
Research Integrity, LLC | |
Owensboro, Kentucky, United States, 42303 | |
United States, Louisiana | |
Grace Research, LLC | |
Bossier City, Louisiana, United States, 71111 | |
Clinical Trials of America, LLC | |
Monroe, Louisiana, United States, 71201 | |
LSU Health Sciences Center | |
New Orleans, Louisiana, United States, 70112 | |
United States, Maine | |
Maine Research Associates | |
Lewiston, Maine, United States, 04240 | |
United States, Maryland | |
Anne Arundel Medical Center | |
Annapolis, Maryland, United States, 21401 | |
Maryland Cardiovascular Specialists | |
Baltimore, Maryland, United States, 21229 | |
MedStar Health Research Institute | |
Baltimore, Maryland, United States, 21237 | |
Metropolitan Cardiovascular Consultants | |
Beltsville, Maryland, United States, 20705 | |
MD Medical Research | |
Oxon Hill, Maryland, United States, 20745 | |
United States, Massachusetts | |
Tufts Medical Center | |
Boston, Massachusetts, United States, 02111 | |
Massachusetts General Hospital | |
Boston, Massachusetts, United States, 02114 | |
East Mountain Medical Associates, PC | |
Great Barrington, Massachusetts, United States, 01230 | |
United States, Michigan | |
Alpena General Hospital | |
Alpena, Michigan, United States, 49707 | |
McLaren Northern Michigan Hospital | |
Petoskey, Michigan, United States, 49770 | |
United States, Minnesota | |
Regions Hospital | |
Saint Paul, Minnesota, United States, 55101 | |
United States, Mississippi | |
Jackson Heart Clinic, P.A. | |
Jackson, Mississippi, United States, 39216 | |
United States, Missouri | |
Saint Luke's Hospital of Kansas City | |
Kansas City, Missouri, United States, 64111 | |
Saint Louis University | |
Saint Louis, Missouri, United States, 63110 | |
St. Louis Center for Clinical Research | |
Saint Louis, Missouri, United States, 63128 | |
St. Louis Heart and Vascular, P.C. | |
Saint Louis, Missouri, United States, 63136 | |
United States, Montana | |
Deaconess Billings Clinic Research Center | |
Billings, Montana, United States, 59101 | |
Bozeman Health Clinical Research | |
Bozeman, Montana, United States, 59718 | |
United States, Nebraska | |
Nebraska Heart Institute | |
Grand Island, Nebraska, United States, 68803 | |
CHI Health Midlands | |
Papillion, Nebraska, United States, 68046 | |
United States, Nevada | |
Healthcare Partners LLC | |
Las Vegas, Nevada, United States, 89109 | |
Palm Research Center | |
Las Vegas, Nevada, United States, 89128 | |
United States, New Jersey | |
Advanced Heart Care, LLC | |
Bridgewater, New Jersey, United States, 08807 | |
Garden State Heart Care, PC | |
Manalapan, New Jersey, United States, 07726 | |
United States, New York | |
Capital Cardiology Associates, PC | |
Albany, New York, United States, 12211 | |
CHEAR Center LLC | |
Bronx, New York, United States, 10455 | |
Cardiac Care and Vascular Medicine, PLLC | |
Bronx, New York, United States, 10469 | |
Trinity Medical WNY, PC | |
Cheektowaga, New York, United States, 14227 | |
North Shore University Hospital | |
Manhasset, New York, United States, 11030 | |
Long Island Cardiovascular Consultants | |
New Hyde Park, New York, United States, 11042 | |
Mount Sinai - PRIME | |
New York, New York, United States, 10025 | |
Harlem Cardiology | |
New York, New York, United States, 10035 | |
Laurelton Heart Specialist, PC | |
Rosedale, New York, United States, 11422 | |
Saratoga Clinical Research, LLC | |
Saratoga Springs, New York, United States, 12866 | |
Northwell Health | |
Southampton, New York, United States, 11968 | |
Stony Brook University Medical Center | |
Stony Brook, New York, United States, 11794 | |
United States, North Carolina | |
Asheville Cardiology Associates | |
Asheville, North Carolina, United States, 28803 | |
Kernodle Clinic West | |
Burlington, North Carolina, United States, 27215 | |
The University of North Carolina at Chapel Hill | |
Chapel Hill, North Carolina, United States, 27599-5021 | |
Novant Health Heart and Vascular Institute | |
Charlotte, North Carolina, United States, 28204 | |
Clinical Research of Gastonia | |
Gastonia, North Carolina, United States, 28054 | |
Clinical Trials of America, Inc | |
Lenoir, North Carolina, United States, 28645 | |
United States, Ohio | |
VA Northeast Ohio Healthcare System | |
Cleveland, Ohio, United States, 44104-1702 | |
Rama Research LLC | |
Marion, Ohio, United States, 43302 | |
United States, Oklahoma | |
South Oklahoma Heart Research Group | |
Oklahoma City, Oklahoma, United States, 73135 | |
United States, Pennsylvania | |
Doylestown Health Cardiology | |
Doylestown, Pennsylvania, United States, 18901 | |
Lycoming Internal Medicine, Inc | |
Jersey Shore, Pennsylvania, United States, 17740 | |
Richard M Kastelic and Associates | |
Johnstown, Pennsylvania, United States, 15905 | |
York Hospital, WellSpan Health | |
York, Pennsylvania, United States, 17403 | |
United States, South Carolina | |
Lowcountry Center for Veterans Research | |
Charleston, South Carolina, United States, 29401 | |
Palmetto Health | |
Columbia, South Carolina, United States, 29203 | |
Clinical Research of Rock Hill | |
Rock Hill, South Carolina, United States, 29732 | |
Palmetto Research Center, LLC | |
Spartanburg, South Carolina, United States, 29302 | |
United States, South Dakota | |
Sanford Research | |
Sioux Falls, South Dakota, United States, 57104 | |
United States, Tennessee | |
The Stern Cardiovascular Center | |
Germantown, Tennessee, United States, 38138 | |
Apex Cardiology/ Research Associates of Jackson | |
Jackson, Tennessee, United States, 38301 | |
Methodist University Hospital | |
Memphis, Tennessee, United States, 38104 | |
United States, Texas | |
Seton Heart Institute | |
Austin, Texas, United States, 78705 | |
Baylor Heart and Vascular Hospital | |
Dallas, Texas, United States, 75226 | |
Soltero Cardiovascular Research Center | |
Dallas, Texas, United States, 75226 | |
University of Texas Southwestern Medical Center | |
Dallas, Texas, United States, 75390-8837 | |
University of North Texas Health Science Center | |
Fort Worth, Texas, United States, 76107 | |
University of Texas Medical Branch at Galveston | |
Galveston, Texas, United States, 77555 | |
Angiocardiac Care of Texas | |
Houston, Texas, United States, 77025 | |
The Methodist Hospital | |
Houston, Texas, United States, 77030 | |
Biopharma Informatic, Inc. Research Center | |
Houston, Texas, United States, 77084 | |
Private Practice Leadership, LLC | |
Katy, Texas, United States, 77493 | |
Baylor Scott and White Health | |
Plano, Texas, United States, 75024 | |
United States, Utah | |
Alpine Research Organization | |
Farmington, Utah, United States, 84025 | |
United States, Virginia | |
Cardiac Health Management Network, P.C. | |
Chester, Virginia, United States, 23836 | |
Cardiology Consultants of Danville, Inc | |
Danville, Virginia, United States, 24541 | |
Carient Heart and Vascular | |
Manassas, Virginia, United States, 20109 | |
Hunter Holmes McGuire VA Medical Center | |
Richmond, Virginia, United States, 23249 | |
Medical College of Virginia Hospitals | |
Richmond, Virginia, United States, 23298 | |
Roanoke Heart Institute PLC | |
Roanoke, Virginia, United States, 24014 | |
Salem VA Medical Center | |
Salem, Virginia, United States, 24153 | |
United States, Washington | |
Virginia Mason Medical Center | |
Seattle, Washington, United States, 98101 | |
United States, Wisconsin | |
Cardiology Associates of Bellin Health | |
Green Bay, Wisconsin, United States, 54301 | |
Meriter Wisconsin Heart | |
Madison, Wisconsin, United States, 53713 | |
Marshfield Clinic | |
Marshfield, Wisconsin, United States, 54449 | |
Aspirus Research Institute | |
Wausau, Wisconsin, United States, 54401 | |
Argentina | |
Hospital Interzonal General de Agudos Dr Jose Penna | |
Bahia Blanca, Argentina, B8001DDU | |
Hospital Italiano Regional del Sur, Bahia Blanca | |
Bahia Blanca, Argentina, B8001HXM | |
CIPREC | |
Caba, Argentina, C1119ACN | |
Hospital Italiano de Buenos Aires | |
Caba, Argentina, C1199ABB | |
Instituto Cardiovascular de Buenos Aires | |
Ciudad Autonoma Buenos Aires, Argentina, C1428ART | |
Glenny Corp. S.A. Bioclinica Argentina | |
Ciudad Autonoma Buenos Aires, Argentina, C1430CKE | |
Centro Médico Viamonte | |
Ciudad Autonoma de Bs As, Argentina, C1120AAC | |
Consultorios Asociados de Endocrinología e Invest Clínica | |
Ciudad Autonoma de BuenosAires, Argentina, C1425AGC | |
Sanatorio Güemes | |
Ciudad Autónoma de Bs As, Argentina, C1180AAX | |
Instituto Medico Elsa Perez SRL (IMEP) | |
Ciudadela, Argentina, 1702 | |
Clinica Privada Colombo- Fundacion Clinica Colombo | |
Cordoba, Argentina, X5002AOQ | |
Instituto Médico DAMIC S.R.L. | |
Cordoba, Argentina, X5003DCE | |
Clinica Coronel Suarez SA | |
Coronel Suarez, Argentina, B7540GHD | |
Instituto de Cardiología de Corrientes | |
Corrientes, Argentina, W3400AMZ | |
Sanatorio Mayo Privado SA | |
Córdoba, Argentina, 5000 | |
Centro de Investigaciones Clinicas Instituto del Corazon | |
Córdoba, Argentina, X5000EVQ | |
Sanatorio Allende S.A. | |
Córdoba, Argentina, X5000JHQ | |
Hospital Privado | |
Córdoba, Argentina, X5016KEH | |
Hospital Italiano de La Plata | |
La Plata, Argentina, B1900AXI | |
Centro de Investigaciones Médicas | |
Mar del Plata, Argentina, B7600FYK | |
Hospital Privado de Comunidad | |
Mar del Plata, Argentina, B7602CBM | |
CER Instituto Médico | |
Quilmes, Argentina, B1878DVB | |
Instituto de Investigaciones Clínicas de Quilmes | |
Quilmes, Argentina, B1878GEG | |
Instituto de Investigaciones Clinicas de Rosario | |
Rosario, Argentina, 2000 | |
Instituto Medico Fundación Grupo Colaborativo Rosario | |
Rosario, Argentina, 2000 | |
Sanatorio Británico | |
Rosario, Argentina, 2000 | |
Sanatorio Plaza | |
Rosario, Argentina, 2000 | |
Instituto CAICI | |
Rosario, Argentina, S2000PBJ | |
CORDIS S.A., Salta | |
Salta, Argentina, A4400ANW | |
Centro Cardiovascular Salta | |
Salta, Argentina, A4406BFP | |
Corporacion Medica de Gral. San Martin S.A. | |
San Martin, Argentina, B1650CSQ | |
Instituto de Cardiología | |
San Miguel de Tucuman, Argentina, T4000JCU | |
Clinica Mayo | |
San Miguel de Tucuman, Argentina, T4000 | |
Investigaciones Clinicas Tucuman | |
San Miguel de Tucumán, Argentina, T4000ICL | |
Centro Medico Luquez | |
San Vicente, Argentina, X5006CBI | |
Centro de Investigaciones Clínicas del Litoral | |
Santa Fe, Argentina, S3000FWO | |
Hospital "Dr. José Maria Cullen" | |
Santa Fé, Argentina, S3000EOZ | |
Clínica Olivos | |
Vicente Lopez, Argentina, 1602 | |
CEMEDIC - Centro de Especialidades Medicas | |
Villa Luro, Argentina, C1440CFD | |
Australia, New South Wales | |
Pendlebury Research | |
Kotara, New South Wales, Australia, 2289 | |
John Hunter Hospital | |
New Lambton Heights, New South Wales, Australia, 2305 | |
Australia, Queensland | |
CORE Research Group | |
Milton, Queensland, Australia, 4064 | |
Gold Coast University Hospital | |
Southport, Queensland, Australia, 4215 | |
Australia, South Australia | |
Royal Adelaide Hospital | |
Adelaide, South Australia, Australia, 5000 | |
Adelaide Medical Research | |
Ashford, South Australia, Australia, 5035 | |
Flinders Medical Centre | |
Bedford Park, South Australia, Australia, 5042 | |
Heart and Vascular Research | |
Fullarton, South Australia, Australia, 5063 | |
The Queen Elizabeth Hospital | |
Woodville South, South Australia, Australia, 5011 | |
Australia, Victoria | |
The Northern Hospital | |
Epping, Victoria, Australia, 3076 | |
Peninsula Private Hospital | |
Frankston, Victoria, Australia, 3199 | |
University Hospital Geelong | |
Geelong, Victoria, Australia, 3220 | |
Australia, Western Australia | |
Mount Hospital | |
Perth, Western Australia, Australia, 6000 | |
Belgium | |
C.H.U. de Charleroi | |
Charleroi, Belgium, 6000 | |
AZ Sint-Blasius | |
Dendermonde, Belgium, 9200 | |
Ziekenhuis Oost-Limburg - Campus Sint-Jan | |
Genk, Belgium, 3600 | |
AZ Maria Middelares | |
Gent, Belgium, 9000 | |
Grand Hôpital de Charleroi | |
Gilly, Belgium, 6060 | |
Jessa Ziekenhuis - Campus Virga Jesse | |
Hasselt, Belgium, 3500 | |
La Louvière - UNIV CHU Tivoli | |
La Louvière, Belgium, 7100 | |
UZ Leuven | |
Leuven, Belgium, 3000 | |
Liège - HOSP CHR de la Citadelle | |
Liège, Belgium, 4000 | |
Brazil | |
FGM - Clínica Paulista de Doenças Cardiovasculares | |
Bela Vista, Brazil, 01323-000 | |
Hospital Felicio Rocho | |
Belo Horizonte, Brazil, 30110-060 | |
Hospital Vera Cruz | |
Belo Horizonte, Brazil, 30140-092 | |
L2IP -Instituto de Pesquisas Clínicas Ltda. | |
Brasília, Brazil, 70200-730 | |
ICDF - Instituto de Cardiologia do Distrito Federal | |
Brasília, Brazil, 70673-900 | |
CECAP - Centro de Cardiologia Clínica | |
Brasília, Brazil, 70710-100 | |
Irmandade da Santa Casa de Misericordia de Curitiba | |
Campina Grande do Sul, Brazil, 83430-000 | |
Centro Especializado em Cardiol Loema Instituto de Pesq Clin | |
Campinas, Brazil, 13010-001 | |
IPECC - Instituto de Pesquisa Clínica de Campinas | |
Campinas, Brazil, 13060-080 | |
CAEP - Centro Avançado de Estudos e Pesquisas Ltda.,Campinas | |
Campinas, Brazil, 13087-567 | |
Hospital Universitário | |
Canoas, Brazil, 92425-900 | |
IPCEM - Instituto de Pesquisa Clínica para Estudos Multicêntricos - Universidade de Caxias do Sul | |
Caxias do Sul, Brazil, 95070-560 | |
Irmandade da Santa Casa de Misericórdia de Curitiba | |
Curitiba, Brazil, 80230-130 | |
Via Medica | |
Goiânia, Brazil, 74223-130 | |
HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás | |
Goiânia, Brazil, 74605-020 | |
ICM - Instituto do Coracao de Marilia | |
Marília, Brazil, 17515-000 | |
Hospital São Vicente de Paulo | |
Passo Fundo, Brazil, 99010-080 | |
Santa Casa de Misericórdia de Porto Alegre | |
Porto Alegre, Brazil, 90035-074 | |
Centro de Pesquisas em Diabetes | |
Porto Alegre, Brazil, 90035-170 | |
Hospital de Clínicas de Porto Alegre | |
Porto Alegre, Brazil, 90035-903 | |
Instituto de Cardiologia Rio Grande do Sul | |
Porto Alegre, Brazil, 90620-001 | |
Hospital Agamenon Magalhaes | |
Recife, Brazil, 52051-380 | |
H.C.da Fac. de Medicina de Ribeirao Preto | |
Ribeirao Preto, Brazil, 14048-900 | |
Hospital Universitário Pedro Ernesto UERJ | |
Rio de Janeiro, Brazil, 20551-030 | |
CCBR - Rio de Janeiro - BR | |
Rio de Janeiro, Brazil, 22271-100 | |
Cardresearch Cardiologia Assistencial e de Pesquisas Ltda | |
Santa Efigenia, Brazil, 30150-240 | |
Pesquisare | |
Santo André, Brazil, 09080-110 | |
Praxis Pesquisa Médica | |
Santo André, Brazil, 09090-790 | |
Hospital de Base - Fac Med de Sao Jose do Rio Preto | |
Sao Jose do Rio Preto, Brazil, 15090-000 | |
Centro de Pesquisa Clinica - CPCLIN | |
Sao Paulo, Brazil, 01228-200 | |
CEPIC - Centro Paulista de Investigacao Clinica | |
Sao Paulo, Brazil, 04266-010 | |
INCOR e Hospital das Clínicas da Universidade de São Paulo | |
Sao Paulo, Brazil, 05403-000 | |
CEMEC - Centro Multidisciplinar de Estudos Clínicos | |
São Bernardo do Campo, Brazil, 09780-000 | |
CDEC BRASIL - Centro de Desenvolvimento em Estudos Clínicos Brasil | |
São Paulo, Brazil, 04020-060 | |
Dr. Consulta | |
São Paulo, Brazil, 05016-090 | |
CEDOES - Diagnóstico e Pesquisa,Vitória | |
Vitória, Brazil, 29055-450 | |
Santa Casa de Votuporanga | |
Votuporanga, Brazil, 15500-003 | |
Canada, Alberta | |
Royal Alexandra Hospital | |
Edmonton, Alberta, Canada, T5H 3V9 | |
Canada, British Columbia | |
Medical Arts Health Research Group | |
North Vancouver, British Columbia, Canada, V7M 2H4 | |
Vancouver General Hospital | |
Vancouver, British Columbia, Canada, V5Z 1M9 | |
Victoria Heart Institute Foundation | |
Victoria, British Columbia, Canada, V8R 1B2 | |
Canada, Manitoba | |
St. Boniface General Hospital | |
Winnipeg, Manitoba, Canada, R2H 2A6 | |
Canada, New Brunswick | |
G.A. Research Associates Ltd | |
Moncton, New Brunswick, Canada, E1G 1A7 | |
Canada, Nova Scotia | |
QEII Health Sciences Centre | |
Halifax, Nova Scotia, Canada, B3H 3A7 | |
Canada, Ontario | |
Brampton Cardio Pulmonary Clinic | |
Brampton, Ontario, Canada, L6W 2X7 | |
Brampton Research Associates | |
Brampton, Ontario, Canada, L6Z 4N5 | |
JBN Medical Diagnostic Services Inc. | |
Burlington, Ontario, Canada, L7M 4Y1 | |
Cambridge Cardiac Care Inc. | |
Cambridge, Ontario, Canada, N1R 6V6 | |
Dr. Saul Vizel | |
Cambridge, Ontario, Canada, N1R 7R1 | |
Curnew Medicine Professional Corporation | |
Hamilton, Ontario, Canada, L8L 0A9 | |
Hamilton General Hospital | |
Hamilton, Ontario, Canada, L8L 2X2 | |
University Hospital (LHSC) | |
London, Ontario, Canada, N6A 5A5 | |
PACE (Partners in Advanced Cardiac Evaluation) | |
Newmarket, Ontario, Canada, L3Y 2P6 | |
M Heffernan Medicine Professional Corp. | |
Oakville, Ontario, Canada, L6K 3W7 | |
Kawartha Cardiology Clinical Trials | |
Peterborough, Ontario, Canada, K9J 0B2 | |
Heart Health Institute | |
Scarborough, Ontario, Canada, M1B 4Z8 | |
Scarborough Cardiology Research | |
Scarborough, Ontario, Canada, M1E 5E9 | |
Cardiovascular Contract Research Organization LTD | |
Sudbury, Ontario, Canada, P3E 3Y9 | |
Canadian Phase Onward Inc. | |
Toronto, Ontario, Canada, M3J 0K2 | |
North York Diagnostic and Cardiac Centre | |
Toronto, Ontario, Canada, M6B 1N6 | |
Mohan Babapulle Medicine Professional Medicine | |
Waterloo, Ontario, Canada, N2T 0C1 | |
Dr. Louis C.H. Yao | |
York, Ontario, Canada, M9N 1W4 | |
Canada, Quebec | |
ViaCar Recherche Clinique Inc | |
Brossard, Quebec, Canada, J4Z 2K9 | |
ViaCar Recherche Clinique Inc | |
Greenfield Park, Quebec, Canada, J4V 2G8 | |
Centre de Dépistage et Recherche Cardiovasculaire Rive-Sud | |
Longeuil, Quebec, Canada, J4M 2X1 | |
Montreal Heart Institute | |
Montreal, Quebec, Canada, H1T 1C8 | |
Clinique Santé Cardio MC | |
Montreal, Quebec, Canada, H1T 3Y7 | |
Montreal General Hospital - McGill University Health Centre | |
Montreal, Quebec, Canada, H3G 1A4 | |
McGill University Health Centre (MUHC) | |
Montreal, Quebec, Canada, H4A 3J1 | |
Canada, Saskatchewan | |
Royal University Hospital | |
Saskatoon, Saskatchewan, Canada, S7N 0W8 | |
Canada | |
IUCPQ (Laval University) | |
Quebec, Canada, G1V 4G5 | |
China | |
Cardiovascular Institute and Fu Wai Hospital | |
Beijing, China, 100037 | |
Beijing Friendship Hospital | |
Beijing, China, 100050 | |
First Hospital of Jilin University | |
Changchun, China, 130021 | |
Hunan Provincial People's Hospital | |
Changsha, China, 410005 | |
2nd Xiangya Hospital of Central South University | |
Changsha, China, 410011 | |
The Third Hospital of Changsha | |
Changsha, China, 410015 | |
Dongguan People's Hospital | |
Dongguan, China, 523059 | |
The First Affiliated Hospital of Fujian Medical University | |
Fuzhou, China, 350005 | |
The First Afiliated Hospital, Sun Yet-sen University | |
Guangzhou, China, 510080 | |
Guangzhou First Municipal People's Hospital | |
Guangzhou, China, 510180 | |
Haikou People's Hospital | |
Haikou, China, 570208 | |
HaiNan Provincial People's Hospital | |
Haikou, China, 570311 | |
The First Affiliated Hospital of Lanzhou University | |
Lanzhou, China, 730000 | |
The Second Affiliated Hospital of Lanzhou Medical University | |
Lanzhou, China, 730030 | |
The Affiliated Hospital of Southwest Medical University | |
Luzhou, China, 646099 | |
Nanchang University Affiliated 3rd Hospital | |
Nanchang, China, 330008 | |
First Hospital Affiliated with Nanjing Medical University | |
Nanjing, China, 210029 | |
Huashan Hospital, Fudan University | |
Shanghai, China, 200040 | |
General Hospital of Shenyang Military Region | |
Shenyang, China, 110016 | |
Shengjing Hospital of China Medical University | |
Shenyang, China, 110072 | |
Tianjin Union Medical Center Nankai University Affiliated Hospital | |
Tianjin, China, 300121 | |
Tongji Hospital, Tongji University | |
Wuhan, China, 430030 | |
Renmin Hospital of Wuhan University | |
Wuhan, China, 430060 | |
First Affiliated Hospital of Xi'an JiaoTong University | |
Xi'an, China, 710061 | |
Yanbian University Hospital | |
Yanji, China, 133000 | |
the first people hospital of Yue Yang | |
Yueyang, China, 414000 | |
Affiliated Hospital of Jiangsu University | |
Zhenjiang, China, 212013 | |
Colombia | |
Corazon IPS S.A.S. | |
Barranquilla, Colombia, 080003 | |
Centro de Reumatologia y Ortopedia SAS, Barranquilla | |
Barranquilla, Colombia, 080020 | |
IPS Centro Cientifico Asistencia | |
Barranquilla, Colombia, 080020 | |
CardioColombia S.A.S. | |
Bogota D.C, Colombia, 111611 | |
Endocare Research Institute | |
Bogota, Colombia, 111611 | |
IPS Centro Medico Julián Coronel S.A. | |
Cali, Colombia, 760002 | |
Fundación Valle del Lili | |
Cali, Colombia, 760032 | |
Centro de Investigaciones Clinicas S.A.S | |
Cali, Colombia, 760036 | |
Centro de Diagnostico Cardilogico | |
Cartagena, Colombia, 130001 | |
Centro cardiovascular Aristides | |
Cartagena, Colombia, 130010 | |
Fundación Cardiovascular de Colombia | |
Floridablanca, Colombia, 681002 | |
Asociacion IPS Medicos Internistas de Caldas | |
Manizales, Colombia, 170004 | |
Promotora Medica Las Americas SA | |
Medellin, Colombia, 050025 | |
Czechia | |
Poliklinika Humanitas | |
Bilovec, Czechia, 74301 | |
Internal and Cardiology Practice, MUDr. Karel Kamenik, Brno | |
Brno, Czechia, 603 00 | |
MUDr. Alexandra Ludkova | |
Brno, Czechia, 615 00 | |
University Hospital Brno | |
Brno, Czechia, 625 00 | |
Vojenska nemocnice Brno | |
Brno, Czechia, 63600 | |
Nemocnice Milosrdnych bratri | |
Brno, Czechia, 63900 | |
Fakultni nemocnice u sv. Anny v Brne | |
Brno, Czechia, 656 91 | |
Univ.Hosp U Svate Anny, I.Internal Clinic-Cardiology,Brno | |
Brno, Czechia, 65691 | |
Edumed s.r.o | |
Broumov, Czechia, 55001 | |
MUDr. Jan Hubac, s.r.o. Kardiologicka ambulance | |
Chrudim, Czechia, 53702 | |
Hospital Frydek Mistek | |
Frydek-Mistek, Czechia, 73818 | |
Nemocnice Havlickuv Brod p.o. | |
Havlickuv Brod, Czechia, 580 22 | |
Gepamed s.r.o., Pulm. Outpat. Office, Hradec Kralove | |
Hradec Kralove, Czechia, 50002 | |
KardioLouny s.r.o. | |
Louny, Czechia, 440 01 | |
InterKardioML s.r.o. | |
Marianske Lazne, Czechia, 353 01 | |
Zdenek Vomacka | |
Olomouc, Czechia, 779 00 | |
PV-Kardiologie s.r.o. | |
Pardubice, Czechia, 53002 | |
Corintez s.r.o. | |
Prague, Czechia, 158 00 | |
Vseobecna fakultni nemocnice V Praze | |
Praha 2, Czechia, 128 00 | |
University Thomayer's Hospital | |
Praha 4 - Krc, Czechia, 140 59 | |
Institute for Clinical and Experimental Medicine | |
Praha 4, Czechia, 140 21 | |
University Hospital Motol | |
Praha 5, Czechia, 15006 | |
Kardio Vaclavik s.r.o. | |
Prerov, Czechia, 75000 | |
Nemocnice Trebic p.o. | |
Trebic, Czechia, 674 01 | |
Kardiologicka ambulance | |
Tremosna, Czechia, 33011 | |
Kardiologicka ambulance MUDr. Ferkl s.r.o. | |
Trutnov, Czechia, 541 01 | |
Clinical Trials Services s.r.o | |
Uherske Hradiste, Czechia, 68601 | |
Cardiology Private Practice | |
Unicov, Czechia, 783 91 | |
Angiocor s.r.o | |
Zlin, Czechia, 76001 | |
KIGE s.r.o | |
Znojmo, Czechia, 66902 | |
Germany | |
Universitätsklinikum Aachen, AöR | |
Aachen, Germany, 52074 | |
Praxis Dr. Rieker, Berlin | |
Berlin, Germany, 10789 | |
Vivantes Netzwerk für Gesundheit GmbH | |
Berlin, Germany, 10967 | |
Charité - Universitätsmedizin Berlin | |
Berlin, Germany, 12203 | |
Vivantes Netzwerk für Gesundheit GmbH | |
Berlin, Germany, 12351 | |
Charité - Universitätsmedizin Berlin | |
Berlin, Germany, 13353 | |
Klinikum Bielefeld gGmbH | |
Bielefeld, Germany, 33604 | |
Augusta-Kranken-Anstalt gGmbH | |
Bochum, Germany, 44791 | |
Praxis Dr. Menzel | |
Dessau-Roßlau, Germany, 06846 | |
St. Johannes Hospital Dortmund | |
Dortmund, Germany, 44137 | |
Städtisches Klinikum Dresden | |
Dresden, Germany, 01067 | |
Universitätsklinikum Carl Gustav Carus Dresden | |
Dresden, Germany, 01307 | |
Helios Klinikum Erfurt | |
Erfurt, Germany, 99089 | |
Studienzentrum Bocholderstraße | |
Essen, Germany, 45355 | |
ClinPhenomics GmbH & Co KG, Frankfurt | |
Frankfurt, Germany, 60596 | |
Universitätsmedizin Göttingen, Georg-August-Universität | |
Göttingen, Germany, 37075 | |
Medizinische Hochschule Hannover | |
Hannover, Germany, 30625 | |
Universitätsklinikum Heidelberg | |
Heidelberg, Germany, 69120 | |
Universitätsklinikum des Saarlandes | |
Homburg, Germany, 66421 | |
Universitätsklinikum Jena | |
Jena, Germany, 07740 | |
Universitätsklinikum Schleswig-Holstein, Campus Kiel | |
Kiel, Germany, 24105 | |
Asklepios Klinik Langen-Seligenstadt GmbH | |
Langen, Germany, 63225 | |
Märkische Gesundheitsholding GmbH & Co. KG, Klinikum Lüdenscheid | |
Lüdenscheid, Germany, 58515 | |
Praxis Dr. Sarnighausen, Lüneburg | |
Lüneburg, Germany, 21339 | |
Katholisches Klinikum Mainz | |
Mainz, Germany, 55131 | |
Gemeinschaftspraxis Drs. Kohler/Salbach, Mannheim | |
Mannheim, Germany, 68165 | |
Deutsches Herzzentrum München | |
München, Germany, 80636 | |
Gemeinschaftspraxis Dres Haggenmiller/Jeserich | |
Nürnberg, Germany, 90402 | |
Kardiologische Praxis Papenburg | |
Papenburg, Germany, 26871 | |
Universitätsklinikum Regensburg | |
Regensburg, Germany, 93053 | |
Praxis Dr. Stenzel, Riesa | |
Riesa, Germany, 01587 | |
Zentrum für Klinische Forschung | |
Wangen im Allgäu, Germany, 88239 | |
Josephs-Hospital Warendorf | |
Warendorf, Germany, 48231 | |
Kardiologische Praxis, Wermsdorf | |
Wermsdorf, Germany, 04779 | |
Petrus-Krankenhaus | |
Wuppertal, Germany, 42283 | |
Hungary | |
Lausmed Kft. Outpatient Unit of Internal Medicine | |
Baja, Hungary, 6500 | |
Belgyogyaszati es Kardiologiai Maganrendelo | |
Bekescsaba, Hungary, 5600 | |
Budai Irgalmasrendi Korhaz | |
Budapest, Hungary, 1023 | |
Clinexpert Kft. | |
Budapest, Hungary, 1033 | |
Bajcsy-Zsilinszky Hospital and Clinic | |
Budapest, Hungary, 1106 | |
Semmelweis University | |
Budapest, Hungary, 1122 | |
Milit.Hosp.-State Health Cent. | |
Budapest, Hungary, 1134 | |
Uzsoki Street Hospital, Budapest | |
Budapest, Hungary, 1145 | |
Nehezlegzes Ambulancia | |
Debrecen, Hungary, 4027 | |
University Debrecen Hospital | |
Debrecen, Hungary, 4032 | |
Bugat Pal Hospital, Gyongyos | |
Gyongyos, Hungary, 3200 | |
Studium Egeszseghaz Kft. | |
Kalocsa, Hungary, 6300 | |
Selye Janos Hospital Komarom | |
Komarom, Hungary, 2921 | |
Dorottya Kanizsai Hospital | |
Nagykanizsa, Hungary, 8800 | |
Medifarma-98 Kft. | |
Nyiregyhaza, Hungary, 4400 | |
Dr. Nagy Laszlo Kardiologiai Maganrendeles | |
Oroshaza, Hungary, 5900 | |
University of Pecs | |
Pecs, Hungary, 7624 | |
Da Vinci Private Clinic | |
Pecs, Hungary, 7635 | |
Fejer County Saint George University Teaching Hospital | |
Szekesfehervar, Hungary, 8000 | |
Veszpremi Sziv es Egeszseg Centrum | |
Veszprem, Hungary, 8200 | |
India | |
Doctor Jivraj Mehta Smarak Health Foundation | |
Ahmedabad, India, 380007 | |
Kamalnayan Bajaj Hospital | |
Aurangabad, India, 431 005 | |
Narayana Institute of Cardiac Sciences | |
Bangalore, India, 560099 | |
Rajarajeswari Medical College | |
Bengaluru, India, 560074 | |
Madras Medical Mission, | |
Chennai, India, 600 037 | |
Apollo Speciality Hospital | |
Chennai, India, 600006 | |
Medanta-The Medicity | |
Gurgaon, India, 122001 | |
GNRC Hospital | |
Guwahati, India, 781006 | |
B.M. Birla Heart research Centre | |
Kolkatta, India, 700027 | |
Siddhi Hospital | |
Nashik, India, 422007 | |
Vijan Cardiac and Critical Care Centre | |
Nasik, India, 422005 | |
GB Pant Hospital | |
New Delhi, India, 110002 | |
Fortis Escorts Heart Institute | |
New Delhi, India, 110025 | |
Sir Gangaram Hospital | |
New Delhi, India, 110060 | |
Batra Hospital and Medical Research Centre | |
New Delhi, India, 110062 | |
Italy | |
Azienda Ospedaliera G. Rummo | |
Benevento, Italy, 82100 | |
ASST Papa Giovanni XXIII - A.O. Papa Giovanni XXIII | |
Bergamo, Italy, 24127 | |
Azienda Ospedaliera Universitaria Arcispedale Sant'Anna | |
Cona (FE), Italy, 44124 | |
Ospedale della Val di Chiana Santa Margherita | |
Cortona, Italy, 52040 | |
Milano Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico | |
Milano, Italy, 20122 | |
Centro Cardiologico Monzino-IRCCS | |
Milano, Italy, 20138 | |
Azienda Ospedaliera Universitaria "Federico II" | |
Napoli, Italy, 80131 | |
Azienda Ospedaliera Universitaria Pisana | |
Pisa, Italy, 56126 | |
AOU Policlinico Umberto I | |
Roma, Italy, 00161 | |
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza | |
Roma, Italy, 00189 | |
Istituto Clinico Humanitas | |
Rozzano (MI), Italy, 20089 | |
IRCCS Gruppo Multimedica | |
Sesto San Giovanni (MI), Italy, 20099 | |
Azienda Servizi Sanitari 1 Triestina | |
Trieste, Italy, 34128 | |
Japan | |
Kasugai Municipal Hospital | |
Aichi, Kasugai, Japan, 486-8510 | |
Japanese Red Cross Nagoya Daini Hospital | |
Aichi, Nagoya, Japan, 466-8650 | |
Chiba Heart Clinic | |
Chiba, Chiba, Japan, 263-0043 | |
Kimitsu Chuo Hospital | |
Chiba, Kisarazu, Japan, 292-8535 | |
Seikeikai New Tokyo Heart Clinic | |
Chiba, Matsudo, Japan, 271-0077 | |
Ehime Prefectural Central Hospital | |
Ehime, Matsuyama, Japan, 790-0024 | |
Matsuyama Shimin Hospital | |
Ehime, Matsuyama, Japan, 790-0067 | |
Uwajima City Hospital | |
Ehime, Uwajima, Japan, 798-8510 | |
Fukuiken Saiseikai Hospital | |
Fukui, Fukui, Japan, 918-8503 | |
Fukuoka University Chikushi Hospital | |
Fukuoka, Chikushino, Japan, 818-8502 | |
Fukuokaken Saiseikai Futsukaichi Hospital | |
Fukuoka, Chikushino, Japan, 818-8516 | |
Saiseikai Fukuoka General Hospital | |
Fukuoka, Fukuoka, Japan, 810-0001 | |
National Hospital Organization Kyushu Medical Center | |
Fukuoka, Fukuoka, Japan, 810-8563 | |
Kyushu University Hospital | |
Fukuoka, Fukuoka, Japan, 812-8582 | |
Steel Memorial Yawata Hospital | |
Fukuoka, Kitakyushu, Japan, 805-8508 | |
Japan Community Health Care Organization Kyushu Hospital | |
Fukuoka, Kitakyushu, Japan, 806-8501 | |
Shirakawa Kosei General Hospital | |
Fukushima, Shirakawa, Japan, 961-0005 | |
Ogaki Municipal Hospital | |
Gifu, Ogaki, Japan, 503-8502 | |
Chuno Kosei Hospital | |
Gifu, Seki, Japan, 501-3802 | |
Fukuyama City Hospital | |
Hiroshima, Fukuyama, Japan, 721-8511 | |
Shobara Red Cross Hospital | |
Hiroshima, Shobara, Japan, 727-0013 | |
Matsuda Cardiovascular Clinic | |
Hokkaido, Sapporo, Japan, 003-0026 | |
Teine Keijinkai Clinic | |
Hokkaido, Sapporo, Japan, 006-0811 | |
Tomakomai City Hospital | |
Hokkaido, Tomakomai, Japan, 053-8567 | |
Otaru Kyokai Hospital | |
Hokkaido,Otaru, Japan, 047-8510 | |
Hyogo Prefectural Amagasaki General Medical Center | |
Hyogo, Amagasaki, Japan, 660-8550 | |
Hyogo Brain and Heart Center | |
Hyogo, Himeji, Japan, 670-0981 | |
National Hospital Organization Kobe Medical Center | |
Hyogo, Kobe, Japan, 654-0155 | |
Mito Medical Center | |
Ibaraki, Higashiibaraki-gun, Japan, 311-3193 | |
Tokushukai Koga General Hospital | |
Ibaraki, Koga, Japan, 306-0041 | |
National Hospital Organization Kanazawa Medical Center | |
Ishikawa, Kanazawa, Japan, 920-8650 | |
Mitoyo General Hospital | |
Kagawa, Kanonji, Japan, 769-1695 | |
Kagawa Prefectural Central Hospital | |
Kagawa, Takamatsu, Japan, 760-8557 | |
Sekishinkai Second Kawasaki Saiwai Clinic | |
Kanagawa, Kawasaki, Japan, 212-0021 | |
Yamamoto Clinic | |
Kanagawa, Sagamihara, Japan, 252-0311 | |
Kanagawa Cardiovascular and Respiratory Center | |
Kanagawa, Yokohama, Japan, 236-0051 | |
Japanese Red Cross Kumamoto Hospital | |
Kumamoto, Kumamoto, Japan, 861-8520 | |
Seiwakai Suizenji Touya Hospital | |
Kumamoto, Kumamoto, Japan, 862-0950 | |
Kumamoto Rosai Hospital | |
Kumamoto, Yatsushiro, Japan, 866-8533 | |
Omi Medical Center | |
Kusatsu, Japan, 525-8585 | |
Uji-Tokushukai Medical Center | |
Kyoto, Uji, Japan, 611-0041 | |
Sendai Kousei Hospital | |
Miyagi, Sendai, Japan, 980-0873 | |
Sendai Tokushukai Hospital | |
Miyagi, Sendai, Japan, 981-3131 | |
National Hospital Organization Sendai Medical Center | |
Miyagi, Sendai, Japan, 983-8520 | |
Miyazaki Medical Association Hospital | |
Miyazaki, Miyazaki, Japan, 880-2102 | |
Hokushin General Hospital | |
Nagano, Nakano, Japan, 383-8505 | |
Nagasaki Medical Center | |
Nagasaki, Omura, Japan, 856-8562 | |
Oita Medical Center | |
Oita, Oita, Japan, 870-0263 | |
Okayama City General Medical Center | |
Okayama, Okayama, Japan, 700-8557 | |
Naha City Hospital | |
Okinawa, Naha, Japan, 902-8511 | |
Nanbu Tokushukai Hospital | |
Okinawa, Shimajiri-gun, Japan, 901-0493 | |
Urasoe General Hospital | |
Okinawa, Urasoe, Japan, 901-2132 | |
Higashiosaka City Medical Center | |
Osaka, Higashiosaka, Japan, 578-8588 | |
Kitano Hospital | |
Osaka, Osaka, Japan, 530-8480 | |
Yodogawa Christian Hospital | |
Osaka, Osaka, Japan, 533-0024 | |
Hokusetsu General Hospital | |
Osaka, Takatsuki, Japan, 569-8585 | |
San-Ai Hospital | |
Saitama, Saitama, Japan, 338-0837 | |
Kosekai Iwatsuki-minami Hospital | |
Saitama, Saitama, Japan, 339-0033 | |
Tokushima Prefectural Central Hospital | |
Tokushima, Tokushima, Japan, 770-8539 | |
National Hospital Organization Tokyo Medical Center | |
Tokyo, Meguro-ku, Japan, 152-8902 | |
Ome Municipal General Hospital | |
Tokyo, Ome, Japan, 198-0042 | |
Tokyo Rosai Hospital | |
Tokyo, Ota-ku, Japan, 143-0013 | |
Sekino Hospital | |
Tokyo, Toshima-ku, Japan, 171-0014 | |
Minami Wakayama Medical Center | |
Wakayama, Tanabe, Japan, 646-8558 | |
Kanmon Medical Center | |
Yamaguchi, Shimonoseki, Japan, 752-8510 | |
Korea, Republic of | |
Inje University Busan Paik Hospital | |
Busan, Korea, Republic of, 47392 | |
Dong-A University Hospital | |
Busan, Korea, Republic of, 49201 | |
Chungbuk National University Hospital | |
Cheongju-si, Korea, Republic of, 28644 | |
Chungnam National University Hospital | |
Daejeon, Korea, Republic of, 35015 | |
Chonnam National University Hospital | |
Gwangju, Korea, Republic of, 61469 | |
Seoul National University Bundang Hospital | |
Gyeonggi-Do, Korea, Republic of, 13620 | |
Gachon University Gil Medical Center | |
Incheon, Korea, Republic of, 21565 | |
Seoul National University Hospital | |
Seoul, Korea, Republic of, 03080 | |
Severance Hospital | |
Seoul, Korea, Republic of, 03722 | |
Asan Medical Center | |
Seoul, Korea, Republic of, 05505 | |
Samsung Medical Center | |
Seoul, Korea, Republic of, 06351 | |
Korea University Guro Hospital | |
Seoul, Korea, Republic of, 08308 | |
Wonju Severance Christian Hosp | |
Wonju-si, Korea, Republic of, 26426 | |
Mexico | |
Hospital Cardiologica Aguascalientes | |
Aguascalientes, Mexico, 20230 | |
Centro de Investigacion Biomedica y Farmaceutica, S.C. | |
Distrito Federal, Mexico, 03100 | |
Hospital Ramon Garibay | |
Guadalajara, Mexico, 44100 | |
Diseño y Planeación en Investigación Médica SC | |
Guadalajara, Mexico, 44130 | |
Unidad de Investigacion Clinica Cardiometabolica de Occident | |
Guadalajara, Mexico, 44150 | |
Cardiologia Clinica e Intervencionista | |
Guadalajara, Mexico, 44670 | |
Centro de Investigación Clinica Acelerada, S.C. | |
Mexico, Mexico, 07020 | |
Instituto Cardiovascular de Monclova, S de RL de CV | |
Monclova, Mexico, 25750 | |
CEDOPEC-Ctro Esp en Diab, Obesidad y Prev de Enf Cardiovasc | |
México, Mexico, C.P. 11650 | |
Hospital Universitario Dr Jose Eleuterio Gonzalez | |
Nuevo Leon, Mexico, 64460 | |
Centro Integral Medico SJR S.C. | |
San Juan del Rio, Mexico, 76800 | |
Cardioarritmias e Investigación S.C | |
San Luis Potosi, Mexico, 78213 | |
Centro de Investigacion Cardiovascular y Metabolica | |
Tijuana, Mexico, 22500 | |
Centro de Investigacion Medica Alberto Bazzoni S.A. de C.V. | |
Torreon, Mexico, 27000 | |
Netherlands | |
Ziekenhuisgroep Twente locatie Almelo | |
Almelo, Netherlands, 7609 PP | |
BovenIJ Ziekenhuis | |
Amsterdam, Netherlands, 1034 CS | |
Onze Lieve Vrouwe Gasthuis, Locatie West | |
Amsterdam, Netherlands, 1061 AE | |
Amsterdam UMC Locatie VUMC | |
Amsterdam, Netherlands, 1081HV | |
Onze Lieve Vrouwe Gasthuis | |
Amsterdam, Netherlands, 1091AC | |
Amsterdam UMC, Locatie AMC | |
Amsterdam, Netherlands, 1105 AZ | |
Rode Kruis Ziekenhuis Beverwijk | |
Beverwijk, Netherlands, 1942 LE | |
Tergooiziekenhuizen locatie Blaricum | |
Blaricum, Netherlands, 1261 AN | |
Amphia Ziekenhuis | |
Breda, Netherlands, 4818 CK | |
Ziekenhuis Gelderse Vallei | |
EDE, Netherlands, 6716 RP | |
Catharina Ziekenhuis | |
Eindhoven, Netherlands, 5623 EJ | |
Universitair Medisch Centrum Groningen | |
Groningen, Netherlands, 9713 GZ | |
Zuyderland Medisch Centrum | |
Heerlen, Netherlands, 6419 PC | |
Maastricht University | |
Maastricht, Netherlands, 6229 HX | |
Diaconessenhuis Meppel | |
Meppel, Netherlands, 7943 KA | |
St. Antonius ziekenhuis, locatie Nieuwegein | |
Nieuwegein, Netherlands, 3435 CM | |
Radboud Universitair Medisch Centrum | |
Nijmegen, Netherlands, 6525 GL | |
Franciscus Gasthuis | |
Rotterdam, Netherlands, 3045 PM | |
De Heel - Zaans Medisch Centrum | |
Zaandam, Netherlands, 1502 DV | |
Gelre Ziekenhuis Zutphen | |
Zutphen, Netherlands, 7207 AE | |
Poland | |
Univ. Clinic Hosp, Bialystok | |
Bialystok, Poland, 15-276 | |
KLIMED Marek Klimkiewicz | |
Bialystok, Poland, 15-765 | |
ClinicMed Badurski i wspolnicy Spolka Jawna, Bialystok | |
Bialystok, Poland, 15-879 | |
American Heart of Poland Sp. z o.o. | |
Bielsko-Biala, Poland, 43-316 | |
NZOZ Centrum Medyczne KERmed | |
Bydgoszcz, Poland, 85231 | |
Polsko-Amerykanskie Kliniki Serca | |
Chorzow, Poland, 32-500 | |
American Heart of Poland Sp. z o.o. | |
Dabrowa Gornicza, Poland, 41-300 | |
Poradnia Kardiologiczna Jaroslaw Jurowiecki | |
Gdansk, Poland, 80-286 | |
University Clinical Center, Gdansk | |
Gdansk, Poland, 80-952 | |
Indywidualna Specjalistyczna Praktyka Lekarska | |
Gdynia, Poland, 81-157 | |
NZOZ Pro-Cordis Sopockie Centrum Bad. Kardiolog. | |
Gdynia, Poland, 81-423 | |
Szpital Zakonu Bonifratow Sp. z o.o. | |
Katowice, Poland, 40-211 | |
Specialistic Cardiology&Hypertension Out-patient Clin,Kielce | |
Kielce, Poland, 25525 | |
Leszek Bryniarski Specialized Medical Cabinet | |
Krakow, Poland, 30-082 | |
Krakow Specialistic Hospital of John Paul II | |
Krakow, Poland, 31-202 | |
ETG Lodz | |
Lodz, Poland, 90-302 | |
Nzoz Salus | |
Lodz, Poland, 91-002 | |
Individual Specialized Practice | |
Lodz, Poland, 94-255 | |
Lowickie Cardiology Center | |
Lowicz, Poland, 99-400 | |
American Heart of Poland Sp. z o.o. | |
Nysa, Poland, 48-300 | |
Medicome Sp. z o.o. | |
Oswiecim, Poland, 32-600 | |
NZOZ HEUREKA, Piaseczno | |
Piaseczno, Poland, 05-500 | |
Specialized Practice Dr. Janusz Spyra | |
Ruda Slaska, Poland, 41-709 | |
Centrum Medyczne Medyk | |
Rzeszow, Poland, 35-055 | |
Lukmed Lukasz Wozniak | |
Siedlce, Poland, 08-110 | |
ETG Skierniewice | |
Skierniewice, Poland, 96-100 | |
KO-MED Centra Kliniczne Staszow | |
Staszow, Poland, 28-200 | |
The Provincial Polyclinical Hospital in Torun | |
Torun, Poland, 87-100 | |
American Heart of Poland Sp. z o.o. | |
Tychy, Poland, 43-100 | |
American Heart of Poland Sp. z o.o. | |
Ustron, Poland, 43-450 | |
Samodzielny Publiczny Centralny Szpital Kliniczny | |
Warszawa, Poland, 02-097 | |
ETG Warszawa | |
Warszawa, Poland, 02-793 | |
4. Military Clinical Hospital with Polyclinic SP ZOZ | |
Wroclaw, Poland, 50-981 | |
Zgierskie Center of Cardiology MED-PRO | |
Zgierz, Poland, 95-100 | |
Specialist Hospital J. Dietla NZOZ Specialized Clinic "Gemini" | |
Zychlin, Poland, 62-571 | |
Romania | |
Spitalul Clinic De Urgenta "Prof. Dr. Agrippa Ionescu" | |
Balotesti, Romania, 077015 | |
C.M.D.T.A. NEOMED, Brasov | |
Brasov, Romania, 500283 | |
CMDTA Washington, Bucharest | |
Bucharest, Romania, 011794 | |
Emergency Clinical Hospital 'Sf. Panteliomon' | |
Bucharest, Romania, 021659 | |
Emergency University Hospital, Bucharest | |
Bucharest, Romania, 022328 | |
Prof.C.C.Iliescu Hospital, National Institute of Cardiology | |
Bucharest, Romania, 022328 | |
Emergency University Hospital, Bucharest | |
Bucharest, Romania, 050098 | |
Spitalul Clinic Colentina | |
Bucuresti, Romania, 020125 | |
Spitalul Clinic "Prof. Dr. Theodor Burghele" | |
Bucuresti, Romania, 050659 | |
Clinica Medicala Data Plus SRL | |
Bucuresti, Romania, 10192 | |
S.C Cardiomed S.R.L | |
Craiova, Romania, 200505 | |
Spital Judetean Deva | |
Deva, Romania, 330084 | |
S.C Medicali's S.R.L | |
Timisoara, Romania, 300043 | |
Spitalul Clinic Judetean de Urgenta, Timisoara | |
Timisoara, Romania, 300723 | |
Singapore | |
National University Hospital | |
Singapore, Singapore, 119074 | |
National Heart Center | |
Singapore, Singapore, 169609 | |
Tan Tock Seng Hospital | |
Singapore, Singapore, 308433 | |
Khoo Teck Puat Hospital | |
Singapore, Singapore, 768828 | |
South Africa | |
Cardiology Clinical Research | |
Alberton, South Africa, 1449 | |
Iatros International | |
Bloemfontein, South Africa, 9301 | |
Universitas Hospital Cardiology Research | |
Bloemfontein, South Africa, 9301 | |
Corbod Research | |
Cape Town, South Africa, 7500 | |
TREAD Research | |
Cape Town, South Africa, 7500 | |
Tiervlei Trial Centre | |
Cape Town, South Africa, 7530 | |
Excellentis Clinical Trials | |
George, South Africa, 6529 | |
Clinresco | |
Johannesburg, South Africa, 1619 | |
Chris Hani Baragwanath Hospital: Cardiology Department | |
Johannesburg, South Africa, 1862 | |
MERC Research | |
Kempton Park, South Africa, 1619 | |
Into Research | |
Pretoria, South Africa, 181 | |
Dr JM Engelbrecht | |
Somerset West, South Africa, 7130 | |
Clinical Projects Research | |
Worcester, South Africa, 6850 | |
Spain | |
Hospital Quiron. I.C.U. | |
Barcelona, Spain, 08023 | |
Hospital Santa Creu i Sant Pau | |
Barcelona, Spain, 08025 | |
Hospital Sanitas CIMA | |
Barcelona, Spain, 08034 | |
Hospital Universitario Virgen de la Arrixaca | |
El Palmar, Spain, 30120 | |
Hospital General Universitario Gregorio Marañón | |
Madrid, Spain, 28007 | |
Hospital Ramón y Cajal | |
Madrid, Spain, 28034 | |
Hospital La Paz | |
Madrid, Spain, 28046 | |
Hospital Puerta de Hierro | |
Majadahonda, Spain, 28222 | |
Hospital Virgen de la Victoria | |
Malaga, Spain, 29010 | |
Hospital Clínico de Santiago | |
Santiago de Compostela, Spain, 15706 | |
Hospital Virgen Macarena | |
Sevilla, Spain, 41009 | |
Hospital General Universitario de Valencia | |
Valencia, Spain, 46014 | |
Hospital Arnau de Vilanova | |
Valencia, Spain, 46015 | |
United Kingdom | |
Barnet General Hospital | |
Barnet, United Kingdom, EN5 3DJ | |
University Hospital of Wales | |
Cardiff, United Kingdom, CF14 4XU | |
Park & St Francis Surgery | |
Eastleigh, United Kingdom, SO53 4ST | |
Wycombe General Hospital | |
High Wycombe, United Kingdom, HP11 2TT | |
Glenfield Hospital | |
Leicester, United Kingdom, LE3 9QP | |
St Bartholomew's Hospital | |
London, United Kingdom, EC1A 7BE | |
St Mary's Hospital | |
Newport, United Kingdom, PO30 5TG | |
Morriston Hospital | |
Swansea, United Kingdom, SA6 6NL |
Study Chair: | Boehringer Ingelheim | Boehringer Ingelheim |
Documents provided by Boehringer Ingelheim:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Boehringer Ingelheim |
ClinicalTrials.gov Identifier: | NCT03057951 |
Other Study ID Numbers: |
1245.110 2016-002278-11 ( EudraCT Number ) |
First Posted: | February 20, 2017 Key Record Dates |
Results First Posted: | June 6, 2022 |
Last Update Posted: | June 6, 2022 |
Last Verified: | June 2022 |
Studies a U.S. FDA-regulated Drug Product: | Yes |
Studies a U.S. FDA-regulated Device Product: | No |
Heart Failure Heart Diseases Cardiovascular Diseases Empagliflozin |
Sodium-Glucose Transporter 2 Inhibitors Molecular Mechanisms of Pharmacological Action Hypoglycemic Agents Physiological Effects of Drugs |