Cognitive Function After Treatment of Primary CNS Malignancy
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In this study, the investigators propose to evaluate cognitive function and determine the feasibility of neurocognitive assessment using a select CogState test battery in patients with primary intracranial malignancies receiving photon- or proton-based cranial irradiation with curative intent. The investigators will use the CogState software to quantify changes in verbal learning, memory, and executive function over the initial months and years following radiation treatment. Cognitive changes and temporal patterns of function will be compared to baseline performance for each patient. Data regarding cognitive function, fatigue, quality of life, and standard patient reported outcomes will be collected to characterize the daily impact of treatment. In addition, observed outcomes will be correlated with dosimetry values, radiation dose volumes, and anatomic dose distribution.
characterize the rate and magnitude of change in cognitive performance within 12 months of completion of therapy in patients with intracranial malignancies receiving photon- or proton-based cranial irradiation with curative intent [ Time Frame: baseline, completion of treatment, 3 months, 6 months, 1 year and 2 years after radiotherapy ]
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Ages Eligible for Study:
4 Years and older (Child, Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients with primary CNS malignancy
Age ≥ 4 years with primary CNS malignancy
Able to use computer for assessment battery
Receiving photon- or proton-based radiation for primary intracranial malignancy
Demonstrates the capacity to sign informed consent