Percent Change in Baseline Bone Mineral Density (BMD) After Parathyroidectomy in Patients With Primary Hyperparathyroidism
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|ClinicalTrials.gov Identifier: NCT03052075|
Recruitment Status : Recruiting
First Posted : February 14, 2017
Last Update Posted : February 14, 2018
|Condition or disease||Intervention/treatment|
|Primary Hyperparathyroidism||Other: Retrospective Data Review|
|Study Type :||Observational|
|Estimated Enrollment :||250 participants|
|Official Title:||Percent Change in Baseline Bone Mineral Density (BMD) After Parathyroidectomy in Patients With Primary Hyperparathyroidism|
|Actual Study Start Date :||September 3, 2014|
|Estimated Primary Completion Date :||September 2019|
|Estimated Study Completion Date :||September 2020|
Parathyroidectomy Data Review
The research plan is for a retrospective review to be performed of a prospectively maintained parathyroid database within the Department of Surgical Oncology at the University of Texas MD Anderson Cancer Center.
Other: Retrospective Data Review
Retrospective, uncontrolled pre- and post-test design in a case series of approximately 250 patients who underwent parathyroidectomy at MD Anderson Cancer Center (years 1990 - 2013 ) and had bone density measures recorded at baseline and at one year post-surgery. Data extracted from the surgical oncology database for bone mineral density measures for each patient at multiple sites including the lumbar spine, total hip (right/left), femoral neck (right/left), and distal 1/3 radius. All measures recorded from two time points: presurgical (baseline) and postsurgical (all follow-up available dates beginning at 1 year post-parathyroidectomy).
- Percent Change in Bone Mineral Density [ Time Frame: Baseline to at least one year after parathyroidectomy ]Data from the pre- and post-tests plotted and correlations assessed using the Pearson or Spearman rank correlation coefficient. Differences in pre- and post-operative bone mineral density measures at each site tested using a paired t-test.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03052075
|Contact: Nancy D. Perrier, MD||713-792-6940|
|United States, Texas|
|University of Texas MD Anderson Cancer Center||Recruiting|
|Houston, Texas, United States, 77030|
|Principal Investigator:||Nancy D. Perrier, MD||M.D. Anderson Cancer Center|