Serum TRAP-5b Levels in Patients With Generalized Chronic Periodontitis
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|ClinicalTrials.gov Identifier: NCT03043066|
Recruitment Status : Completed
First Posted : February 3, 2017
Last Update Posted : February 3, 2017
|Condition or disease||Intervention/treatment||Phase|
|Chronic Periodontitis||Procedure: Scaling and root planing Drug: scaling and root planing along with antibiotic intervention||Not Applicable|
30 Chronic periodontitis subjects were divided into two groups- group A underwent scaling and root planing and group B underwent scaling and root planing with systemic administration of amoxicillin of 500 mg and metronidazole of 400 mg thrice daily for 7 days.
Periodontal parameters probing pocket depth and clinical attachment level were measured at baseline and at 3rd month. Serum TRAP-5b levels were also measured at baseline, 1 month and at 3rd month.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||30 participants|
|Intervention Model:||Parallel Assignment|
|Intervention Model Description:||Group A - scaling and root planing Group B - scaling and root planing along with antibiotic intervention of amoxicillin and metronidazole|
|Masking:||Double (Participant, Investigator)|
|Official Title:||The Effect of Non-surgical Periodontal Therapy With or Without Systemic Administration of Amoxicillin and Metronidazole on Serum Levels of TRAP-5b in Patients With Generalized Chronic Periodontitis - A Comparative Clinical Study|
|Actual Study Start Date :||March 1, 2016|
|Actual Primary Completion Date :||July 31, 2016|
|Actual Study Completion Date :||October 1, 2016|
Placebo Comparator: Group A -control group
15 subjects underwent scaling and root planing
Procedure: Scaling and root planing
subjects underwent full mouth supragingival and subgingival scaling
Other Name: Non-surgical periodontal therapy
Active Comparator: Group B-Interventional group
15 subjects underwent scaling and root planing along with antibiotic intervention of amoxicillin of 500 mg and metronidazole of 400 mg thrice daily for 7 days
Drug: scaling and root planing along with antibiotic intervention
subjects underwent full mouth supragingival and subgingival scaling along with antibiotic intervention of amoxicillin of 500 mg and metronidazole of 400 mg thrice daily for 7 days
Other Name: Systemic antibiotics
- Serum levels of TRAP-5b [ Time Frame: Baseline and 3 months ]Concentration of serum levels of TRAP-5b was assessed at baseline and at 3rd month using ELISA method.
- Probing pocket depth [ Time Frame: Baseline and 3 months ]Probing pocket depth was measured using Williams periodontal probe at baseline and at 3rd month
- Clinical attachment level [ Time Frame: Baseline and 3 months ]Clinical attachment level was measured as a distance between base of pocket and a fixed point on the crown, such as cemento-enamel junction at baseline and at 3rd month.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03043066
|Principal Investigator:||Sandhya CH, BDS||Meenakshi Ammal Dental College & Hospital|