Early Detection of Cardiac Toxicity in Childhood Cancer Survivors
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|ClinicalTrials.gov Identifier: NCT03038997|
Recruitment Status : Terminated (IRB approval expired)
First Posted : February 1, 2017
Last Update Posted : December 4, 2018
|Condition or disease|
|Heart Failure Cardiotoxicity|
|Study Type :||Observational|
|Actual Enrollment :||42 participants|
|Official Title:||Early Detection of Cardiac Toxicity in Childhood Cancer Survivors|
|Study Start Date :||November 2014|
|Actual Primary Completion Date :||March 11, 2018|
|Actual Study Completion Date :||March 11, 2018|
- Echocardiogram marker measurements pre ABC chemo and post ABC [ Time Frame: At the end of each cardiac MRI exam through study completion, up to 5 years ]•Measure echocardiogram markers on pre anthracycline based chemotherapy (ABC) and post ABC echocardiograms, using standard echocardiogram measurements and speckle tracking.
- Detection of cardiac toxicity on MRI and echocardiogram [ Time Frame: At the end of each cardiac MRI exam through study completion, up to 5 years ]•Measure sensitivity of detecting cardiac toxicity between standard echocardiogram, speckle tracking on echo, and MRI
- Serum biomarkers correlation [ Time Frame: At the end of the study, up to 10 years ]•Correlate measurement of serum biomarkers with prevalence of cardiac changes measured on echocardiograms and MRI imaging.
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03038997
|United States, District of Columbia|
|Children's National Health System|
|Washington, District of Columbia, United States, 20010|
|Principal Investigator:||Niti Dham, MD||Children's National|