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Phase 2 Study of Pembrolizumab, DPX-Survivac Vaccine and Cyclophosphamide in Advanced Ovarian, Primary Peritoneal or Fallopian Tube Cancer

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ClinicalTrials.gov Identifier: NCT03029403
Recruitment Status : Not yet recruiting
First Posted : January 24, 2017
Last Update Posted : January 24, 2017
Sponsor:
Collaborators:
Information provided by (Responsible Party):

Study Description
Brief Summary:

This is a phase 2 study whose purpose is to see whether the combination of of pembrolizumab, DPX-Survivac vaccine and low-dose cyclophosphamide has anti-tumor activity in patients with advanced epithelial ovarian, fallopian tube or primary peritoneal cancer.

DPX-Survivac is an investigational vaccine. A vaccine is a substance that is often given to stimulate the body's immune system (the structure and processes in the body that protects against harmful substances) to help prevent against certain diseases. DPX-Survivac is a vaccine that may teach the immune system to recognize cancer cells and to kill them.

Pembrolizumab is a drug that is approved for the treatment of a certain type of melanoma (a type of skin cancer) and non-small cell lung cancer. Pembrolizumab blocks the function of a protein called programmed cell death receptor-1 (PD-1). PD-1 works by keeping the immune system from destroying cancer cells. Stopping PD-1 from working may help the immune system to fight cancer cells.

Cyclophosphamide is chemotherapy drug that is approved for the treatment of various cancers alone and in combination with other drugs.


Condition or disease Intervention/treatment Phase
Advanced Cancer Ovarian Cancer Primary Peritoneal Carcinoma Fallopian Tube Cancer Drug: Pembrolizumab Biological: DPX-Survivac Drug: Cyclophosphamide Phase 2

Detailed Description:

This study has two phases: a dose escalation phase and a dose expansion phase.

For the dose escalation part, groups of participants will receive one of two dose levels of study drugs to determine the best dose level for further testing.

Once the best dose level is found, additional participant will be enrolled to the dose expansion to further test the safety, tolerability, and efficacy of the study drugs at that dose level in specific types of cancers. All participants will receive pembrolizumab, DPX-Survivac, and low-dose cyclophosphamide.

Participants will be screened for eligibility by standard safety tests and procedures within 28 days of the start of the study drug. Tests and procedures done for research purposes only during this time include archival tumor tissue collection, fresh research biopsy, and blood sample collection for biomarker/genetic/immune research. Participants will also be asked if they agree to an optional fresh research biopsy at disease progression

Eligible participants will receive the following every 21 day cycle:

  • Pembrolizumab, intravenously, at 200 mg, on Day 1 of every cycle.
  • DPX-Survivac, by injection under the skin of the upper thigh in clinic. Participants will receive one priming dose of 0.25 mL of DPX-Survivac on Cycle 1 Day 1. After about 6 weeks, participants will receive an additional boosting dose of 0.25 or 0.5 mL DPX-Survivac depending on the assigned dose level.
  • Cyclophosphamide, orally, at 50 mg, twice a day, starting about 7 days before Cycle 1 Day 1, then continue 7 days off, 7 days on.

While receiving the study treatment, participants will be asked to visit the study site on Day 1 of Cycles 1-8 for tests and procedures. Tests and procedures done for research purposes only include additional blood sample collection and a second fresh research biopsy for biomarker/genetic/immune research.

Participants who benefit from the study treatment may be able to receive additional treatment if they progress after stopping the study treatment.

When participants are taken off the study treatment permanently, they will be asked to return to the study site for an End of Study Treatment visit about 30 days after stopping the study treatment to have tests and procedures done for safety purposes.

Participants who are taken off the study treatment for any reason other than disease progression will continue to have radiological assessments and blood draws every 12 weeks for the first year and every 24 weeks after year 1 until they start a new anti-cancer treatment, disease progression, or the study ends. Participants will continue to be followed for survival and to review any new anti-cancer therapies every 12 weeks.


Study Design

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 42 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Phase 2 Study of Pembrolizumab (MK-3475), DPX-Survivac Vaccine and Low Dose of Cyclophosphamide Combination in Patients With Advanced Ovarian, Primary Peritoneal or Fallopian Tube Cancer
Anticipated Study Start Date : March 13, 2017
Estimated Primary Completion Date : March 13, 2022
Estimated Study Completion Date : September 13, 2022


Arms and Interventions

Arm Intervention/treatment
Experimental: Dose Escalation
Patients with epithelial ovarian, fallopian tube or primary peritoneal cancer.
Drug: Pembrolizumab
Given intravenously in clinic, at 200 mg, on Day 1 of every 21-day cycle.
Other Name: Keytruda
Biological: DPX-Survivac
Given by injection under the skin of the upper thigh in clinic. Participants will receive one priming dose of 0.25 mL of DPX-Survivac on Cycle 1 Day 1. After about 6 weeks, participants will receive an additional boosting dose of 0.25 or 0.5 mL DPX-Survivac.
Drug: Cyclophosphamide
Given orally, at 50 mg, twice a day, starting about 7 days before Cycle 1 Day 1, then continue 7 days off, 7 days on.
Other Name: Procytox
Experimental: Dose Expansion - Cohort A
Patients with platinum-sensitive epithelial ovarian, fallopian tube or primary peritoneal cancer.
Drug: Pembrolizumab
Given intravenously in clinic, at 200 mg, on Day 1 of every 21-day cycle.
Other Name: Keytruda
Biological: DPX-Survivac
Given by injection under the skin of the upper thigh in clinic. Participants will receive one priming dose of 0.25 mL of DPX-Survivac on Cycle 1 Day 1. After about 6 weeks, participants will receive an additional boosting dose of 0.25 or 0.5 mL DPX-Survivac.
Drug: Cyclophosphamide
Given orally, at 50 mg, twice a day, starting about 7 days before Cycle 1 Day 1, then continue 7 days off, 7 days on.
Other Name: Procytox
Experimental: Dose Expansion - Cohort B
Patients with platinum-resistant epithelial ovarian, fallopian tube or primary peritoneal cancer.
Drug: Pembrolizumab
Given intravenously in clinic, at 200 mg, on Day 1 of every 21-day cycle.
Other Name: Keytruda
Biological: DPX-Survivac
Given by injection under the skin of the upper thigh in clinic. Participants will receive one priming dose of 0.25 mL of DPX-Survivac on Cycle 1 Day 1. After about 6 weeks, participants will receive an additional boosting dose of 0.25 or 0.5 mL DPX-Survivac.
Drug: Cyclophosphamide
Given orally, at 50 mg, twice a day, starting about 7 days before Cycle 1 Day 1, then continue 7 days off, 7 days on.
Other Name: Procytox
Experimental: Dose Expansion - Cohort C
Patients with recurrent advanced epithelial ovarian, fallopian tube and primary peritoneal patients with uncommon tumor histologies, including clear cell, mucinous and low grade serous or low grade endometrioid ovarian subtypes.
Drug: Pembrolizumab
Given intravenously in clinic, at 200 mg, on Day 1 of every 21-day cycle.
Other Name: Keytruda
Biological: DPX-Survivac
Given by injection under the skin of the upper thigh in clinic. Participants will receive one priming dose of 0.25 mL of DPX-Survivac on Cycle 1 Day 1. After about 6 weeks, participants will receive an additional boosting dose of 0.25 or 0.5 mL DPX-Survivac.
Drug: Cyclophosphamide
Given orally, at 50 mg, twice a day, starting about 7 days before Cycle 1 Day 1, then continue 7 days off, 7 days on.
Other Name: Procytox


Outcome Measures

Primary Outcome Measures :
  1. Overall response rate (ORR) [ Time Frame: 5 years ]

Secondary Outcome Measures :
  1. Progression free survival (PFS) rate [ Time Frame: 5 years ]
  2. Overall survival (OS) rate [ Time Frame: 5 years ]
  3. Number of side effects [ Time Frame: 5 years ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients must have histologically or cytologically confirmed advanced epithelial ovarian, primary peritoneal or fallopian tube carcinomas.
  • Patients must have radiologically documented disease progression from their prior line of therapy.
  • Patients must have measurable disease based on RECIST 1.1.
  • Have received a front line platinum-based regimen (administered via either IV or IP) following primary or interval debulking surgery with documented disease recurrence.
  • Have fulfilled the following additional requirements regarding prior treatments depending on the cohort that the patient is to be enrolled in.
  • Eastern Cooperative Group (ECOG) performance status <=1.
  • Life expectancy greater than 16 weeks.
  • Availability of archival tumor tissue samples. Additional samples may be requested if tumor tissue provided is not adequate for quality and/or quantity as assessed by the laboratory.
  • Be willing to provide tumor tissue from a newly obtained core or excisional biopsy prior to start treatment and on day 15 of cycle 1.

Exclusion Criteria:

  • Patients who are receiving any other investigational agents.
  • Diagnosis of immunodeficiency or therapy with systemic steroid or any other form of immunosuppressive therapy within 7 days prior to the first dose of trial treatment.
  • History of autoimmune disease, such as but not restricted to, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematous, ankylosing spondylitis, scleroderma, or multiple sclerosis requiring treatment within the last two years. Patients with vitiligo or diabetes are not excluded.
  • Patients with history of thyroiditis within 5 years.
  • Patients with known history of active TB (Bacillus Tuberculosis).
  • Patients with known active central nervous system (CNS) metastases and/or carcinomatous meningitis.
  • Hypersensitivity to Pembrolizumab, DPX-Survivac immunovaccine, Cyclophosphamide or any of their excipients.
  • Patients that have received a live vaccine within 30 days of planned start of study therapy.
  • Prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2 agent or DPX-Survivac vaccine.
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03029403


Contacts
Contact: Amit Oza, M.D. 416-946-2818

Locations
Canada, Ontario
Princess Margaret Cancer Centre Not yet recruiting
Toronto, Ontario, Canada, M5G 2M9
Contact: Amit Oza, M.D.         
Principal Investigator: Amit Oza, M.D.         
Sponsors and Collaborators
University Health Network, Toronto
Merck Sharp & Dohme Corp.
ImmunoVaccine Technologies, Inc.
Investigators
Principal Investigator: Amit Oza, M.D. Princess Margaret Cancer Centre
More Information

Responsible Party: University Health Network, Toronto
ClinicalTrials.gov Identifier: NCT03029403     History of Changes
Other Study ID Numbers: PESCO
First Posted: January 24, 2017    Key Record Dates
Last Update Posted: January 24, 2017
Last Verified: January 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
Fallopian Tube Neoplasms
Genital Neoplasms, Female
Urogenital Neoplasms
Neoplasms by Site
Neoplasms
Fallopian Tube Diseases
Adnexal Diseases
Genital Diseases, Female
Cyclophosphamide
Pembrolizumab
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Antirheumatic Agents
Antineoplastic Agents, Alkylating
Alkylating Agents
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Myeloablative Agonists