Dietary Intake of Alpha-linolenic Acid in Elderly
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|ClinicalTrials.gov Identifier: NCT03025620|
Recruitment Status : Completed
First Posted : January 19, 2017
Last Update Posted : January 19, 2017
|Condition or disease||Intervention/treatment||Phase|
|Cardiovascular Diseases Inflammation Metabolism Disorder, Lipid||Dietary Supplement: Rapeseed oil Dietary Supplement: Sunflower oil||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||254 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Participant, Care Provider, Outcomes Assessor)|
|Official Title:||Investigation of the Relationship Between Alpha-linolenic Acid and Arterial, Biochemical, Biological Parameters in Older Persons With History of Cardiovascular Events and/or Moderate Cognitive Impairment|
|Study Start Date :||November 2006|
|Actual Primary Completion Date :||February 2011|
|Actual Study Completion Date :||December 2011|
Placebo Comparator: Sunflower arm
Participants were supplied with the usual diet of the hospital, daily enriched with 17.5g fat as follows during 42 days: 10 g of sunflower oil (with a high content in linoleic acid) were added into the dinner soup and 7.5g delivered through a 12.5g portion of margarine made with sunflower oil (60% fat) that replaced butter on the breakfast toasts.
Dietary Supplement: Sunflower oil
Placebo comparator arm : Dietary Supplement: sunflower oil supplementation (10g per day) and margarine with a high level of inoleic acid (12.5g per day) during 42 days.
Other Name: Linoleic acid
Active Comparator: Rapeseed arm
Participants were supplied with the usual diet of the hospital, daily enriched with 17.5g fat as follows during 42 days: 10 g of rapeseed oil (with a high content in alpha-linolenic acid) were added into the dinner soup and 7.5g delivered through a 12.5g portion of margarine made with rapeseed oil (60% fat) that replaced butter on the breakfast toasts.
Dietary Supplement: Rapeseed oil
Active comparator arm : Dietary Supplement: rapeseed oil supplementation (10g per day) and margarine with a high level of alpha-linolenic acid (12.5g per day) during 42 days.
Other Name: Alpha-linolenic acid
- Effects of diet supplementation on fatty acid composition in serum and red cell membrane phospholipids, at the end of dietary period [ Time Frame: 6 weeks ]Blood samples have been done at the beginning and at the end of the dietary period. Fatty acids analyses of the red cells and serum have been performed by GC method.
- Pulse wave velocity (PWV) [ Time Frame: 6 weeks ]
Pulse wave velocity values have been performed at the beginning and the end of the dietary period.
The purpose was to evaluate the relationship between PWV and dietary intakes of ALA.
- Others [ Time Frame: 6 weeks ]ApoB ApoA1 Oxydative parameters (ie CRP) Lp(a)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03025620
|hopital Emile Roux|
|Limeil Brevannes, France, 94450|
|Principal Investigator:||olivier henry, MD||Assistance Publique de Paris. Hopital Emile Roux|