Inflammation, Diabetes, Ethnicity and Obesity Cohort (IDEO)
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|ClinicalTrials.gov Identifier: NCT03022682|
Recruitment Status : Recruiting
First Posted : January 16, 2017
Last Update Posted : October 18, 2021
Obesity affects over one third of US adults (>72 million, with BMI ≥30 kg/m2), and the proportion of US adults with BMI ≥40 kg/m2 has doubled in the last 20 years. Obesity is associated with increased mortality through its linkage to comorbidities including diabetes, hypertension, dyslipidemia, osteoarthritis, sleep apnea and psychosocial disturbances. Given its prevalence, impact on morbidity and mortality, and economic cost, limiting the spread of obesity and its consequences is one of the most important problems of our time.
In this proposed study, investigators will recruit subjects from a wide range of body mass index (BMI), ethnicity and Diabetes risk to collect data and blood, stool and adipose tissue samples in the San Francisco bay area.
|Condition or disease|
|Obesity Diabetes Mellitus|
|Study Type :||Observational|
|Estimated Enrollment :||200 participants|
|Official Title:||Development of a Multi-Ethnic, Multimodal Obesity Cohort|
|Study Start Date :||February 2015|
|Estimated Primary Completion Date :||December 2022|
|Estimated Study Completion Date :||December 2022|
Adipose tissue samples are collected from all subjects, including aspirational subcutaneous biopsies from nonsurgical subjects and excisional biopsies, performed intra-operatively by surgical collaborators as required.
Participants also undergo anthropometric measurements, stool collection, blood sample collection for circulating blood cells, serum, and plasma.
Dual-energy x-ray absorptiometry (DXA) scan for amount and distribution of body fat as well as bone density is performed.
Study subjects complete validated questionnaire inventories to measure bio-behavioral issues such as depression, stress, health locus of control, and dietary habits.
- Complete recruitment of IDEO cohort participants to spur novel and creative interactions between investigators that have transformative potential in obesity research. [ Time Frame: 5 years ]number of biological samples collected
- Adipose tissue inflammation and fibrosis [ Time Frame: 5 years ]Quantification ofpro-fibrotic and pro-inflammatory markers in the visceral and subcutaneous adipose tissue
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03022682
|Principal Investigator:||Suneil Koliwad, MD,PhD||University of California, San Francisco|