Women's Heart Attack Research Program: Platelet Sub-Study (HARP) (HARP)
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|ClinicalTrials.gov Identifier: NCT03022552|
Recruitment Status : Recruiting
First Posted : January 16, 2017
Last Update Posted : May 23, 2018
|Condition or disease|
|Study Type :||Observational [Patient Registry]|
|Estimated Enrollment :||200 participants|
|Target Follow-Up Duration:||6 Months|
|Official Title:||Women's Heart Attack Research Program: Platelet Sub-Study (HARP); Platelet Collection for Women With Myocardial Infarction|
|Study Start Date :||August 2016|
|Estimated Primary Completion Date :||April 2020|
|Estimated Study Completion Date :||April 2020|
Women with myocardial infarction (MI) with demonstrated non-obstructive coronary artery disease during cardiac catheterization (less than 50% blockage in any major vessel).
Women with myocardial infarction (MI) with demonstrated obstructive coronary artery disease during cardiac catheterization (50% or greater blockage in any major vessel) or previous history of percutaneous coronary intervention (PCI) or or coronary artery bypass graft (CABG).
Women with stable angina that are age and race matched to women in the MINOCA arm that are clinically referred for cardiac catheterization
- Examination of Platelet Activity Markers [ Time Frame: 1 year ]
- Examination of Markers of Cardiovascular Disease Risk [ Time Frame: 1 year ]This will include additional examination of known thrombosis, Inflammation, metabolic disease, and lipids/lipoprotein markers.
- Cellular and molecular mechanism of myocardial infarction in women [ Time Frame: 1 year ]To further investigate this mechanism, recent advances in microRNA, RNA, DNA expression profiling, and plasma and serum collections will be used.
- Examination of non-coding and coding mRNA profiles in women with MI and matched controls [ Time Frame: 4 years ]Specific transcripts associated with platelet activation, plaque destabilization, and different cardiovascular diseases will be analyzed at the genetic level.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03022552
|Contact: Jeffrey Berger, MD||212 263 email@example.com|
|Contact: Harmony R Reynolds, MDfirstname.lastname@example.org|
|United States, New York|
|NYU Langone Medical Center||Recruiting|
|New York, New York, United States, 10016|
|Contact: Jeffrey Berger, MD|
|Principal Investigator:||Harmony R Reynolds, MD||NYU Langone Medical Center|