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Trial record 89 of 123 for:    hypertension "vitamin d"

Comparison of Vitamin D Status and Vitamin D Receptor Polymorphisms in Patients With High Myopia and Primary Open-angle Glaucoma

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ClinicalTrials.gov Identifier: NCT03021629
Recruitment Status : Completed
First Posted : January 16, 2017
Last Update Posted : July 18, 2017
Sponsor:
Information provided by (Responsible Party):
Lv Yingjuan, Tianjin Medical University Eye Hospital

Brief Summary:
Vitamin D deficiency is known to be significantly associated with high myopia. This study investigated the vitamin D status in patients with high myopia and primary open-angle glaucoma, in order to understand the relationship between high myopia and the development of primary open-angle glaucoma.110 primary open-angle glaucoma patients, 110 high myopia patients and 110 age-matched people in the Han population were enrolled. Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by an enzyme-linked immuno-absorbent assay.Vitamin D receptor polymorphic analysis was studied by polymerase chain reaction-restriction fragment length polymorphism technique.

Condition or disease Intervention/treatment
Vitamin D Deficiency Primary Open-angle Glaucoma High Myopia Vitamin D Receptor Polymorphisms Other: Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by an enzyme-linked immuno-absorbent assay

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Study Type : Observational
Actual Enrollment : 500 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Comparison of Vitamin D Status and Vitamin D Receptor Polymorphisms in Patients With High Myopia and Primary Open-angle Glaucoma
Study Start Date : July 2013
Actual Primary Completion Date : December 2016
Actual Study Completion Date : December 2016


Group/Cohort Intervention/treatment
primary open-angle glaucoma patients
Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by an enzyme-linked immuno-absorbent assay
Other: Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by an enzyme-linked immuno-absorbent assay
Other Name: Vitamin D receptor polymorphic analysis was studied by polymerase chain reaction-restriction fragment length polymorphism technique

high myopia patients
Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by an enzyme-linked immuno-absorbent assay
Other: Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by an enzyme-linked immuno-absorbent assay
Other Name: Vitamin D receptor polymorphic analysis was studied by polymerase chain reaction-restriction fragment length polymorphism technique

age-matched people
Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by an enzyme-linked immuno-absorbent assay
Other: Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by an enzyme-linked immuno-absorbent assay
Other Name: Vitamin D receptor polymorphic analysis was studied by polymerase chain reaction-restriction fragment length polymorphism technique




Primary Outcome Measures :
  1. Serum levels of 1a, 25-Dihydroxyvitamin D3 [ Time Frame: 1 day visit ]

Secondary Outcome Measures :
  1. gene polymorphisms of vitamin D receptor [ Time Frame: 1 day visit ]

Biospecimen Retention:   Samples Without DNA
blood


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Ages Eligible for Study:   55 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
primary open-angle glaucoma patients, high myopia patients and age-matched people in the Han population
Criteria

Inclusion Criteria:

-primary open-angle glaucoma (1) intraocular pressure above 21 mmHg or more in each eye without therapy; (2) wide anterior chamber angle; (3)glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect in at least one eye;(4) visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry in at least one eye.

c(with refractive error >6D) were recruited.

Exclusion Criteria:

  • the presence of any secondary glaucoma with an exfoliation syndrome or a history of ocular trauma, high myopia, macular degeneration, other ocular diseases, and also a known history of systemic diseases and administration of vitamin D3 or other analog.

High myopia patients with ocular disease such as glaucoma, a history of administration of vitamin D3 or other analog or a history of retinopathy or connective tissue disorders associated with myopia, such as Stickler or Marfan syndromes, were not included.


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03021629


Locations
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China, Tianjin
Tianjin Medical University Eye Hospital
Tianjin, Tianjin, China, 300384
Sponsors and Collaborators
Lv Yingjuan

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Responsible Party: Lv Yingjuan, Director, Tianjin Medical University Eye Hospital
ClinicalTrials.gov Identifier: NCT03021629     History of Changes
Other Study ID Numbers: tjykdxykyy6
First Posted: January 16, 2017    Key Record Dates
Last Update Posted: July 18, 2017
Last Verified: July 2017

Additional relevant MeSH terms:
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Vitamin D Deficiency
Ocular Hypertension
Vitamin D
Glaucoma
Glaucoma, Open-Angle
Myopia
Eye Diseases
Refractive Errors
Avitaminosis
Deficiency Diseases
Malnutrition
Nutrition Disorders
Vitamins
Ergocalciferols
Dihydroxycholecalciferols
Micronutrients
Nutrients
Growth Substances
Physiological Effects of Drugs
Bone Density Conservation Agents
Calcium-Regulating Hormones and Agents