The Effect of Using High-flow Nasal Oxygen-delivery System in Patients Under Intravenous General Anesthesia
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03019354|
Recruitment Status : Recruiting
First Posted : January 12, 2017
Last Update Posted : May 30, 2018
|Condition or disease||Intervention/treatment||Phase|
|Pulmonary Atelectases Lung Injury General Anesthesia||Device: high-flow nasal oxygen Device: Oxygen mask||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||60 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||The Effect of Using High-flow Nasal Oxygen-delivery System in Patients Under Intravenous General Anesthesia|
|Study Start Date :||January 2017|
|Estimated Primary Completion Date :||January 2019|
|Estimated Study Completion Date :||January 2019|
Experimental: high-flow nasal oxygen
high-flow nasal oxygen was used during intravenous general anesthesia
Device: high-flow nasal oxygen
Using high-flow nasal oxygen 10 L/min before anesthesia induction, then using high-flow nasal oxygen 30-50 L/min during intravenous general anesthesia.
Other Name: High-flow nasal cannula
Active Comparator: Oxygen mask
oxygen mask was used during intravenous general anesthesia
Device: Oxygen mask
Using oxygen mask with oxygen flow 10 L/min before and during intravenous general anesthesia.
- Chest CT image atelectatic area [ Time Frame: At the end of surgery ]lung atelectasis (-100 to +100 Hounsfield Unit) was calculated and as percent of the total area of the lung at the basal scan.
- postoperative pulmonary complications [ Time Frame: within the first 7 days after surgery ]postoperative pulmonary complications including pneumonia, pleural effusion, and acute lung injury.
- lung injury [ Time Frame: At the end of surgery ]lung injury biomarkers including Clara cell protein, Plasma neutrophil elastase.
- Respiratory gas exchange function [ Time Frame: At the end of surgery ]blood gas analysis including PaO2, PaCO2
- need for supplemental oxygen therapy [ Time Frame: within the first 7 days after surgery ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03019354
|Contact: Chung-Chih Shih, MD||+886 firstname.lastname@example.org|
|Contact: Chung-Chih Shih, MD||+886 email@example.com|
|National Taiwan University Hospital||Recruiting|
|Taipei, Taiwan, 10048|
|Contact: Chung CHih SHih, MD +886 972653379 firstname.lastname@example.org|
|Principal Investigator:||Chun-Yu Wu, MD,PhD||National Taiwan University Hospital|