Neurophysiology of Surround Inhibition in the Human Motor Cortex
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|ClinicalTrials.gov Identifier: NCT03018262|
Recruitment Status : Recruiting
First Posted : January 12, 2017
Last Update Posted : November 13, 2019
Movement disorders have many different causes and symptoms. Researchers still do not fully understand which parts of the brain are involved in fine movement. They want to learn about which brain regions could be abnormal in people with movement disorders.
To better understand how the brain controls movement.
Healthy, right-handed adults age 18-70 years old.
Participants will be screened with a physical exam and questions about their handedness. They may have a urine test.
Participants will have 1 or 2 clinic visits. The first visit will last about 1.5 hours. The second will last about 3 hours.
Participants will have structural magnetic resonance imaging (MRI). A strong magnetic field and radio waves take pictures of the brain. Participants will lie on a table that slides in and out of a metal cylinder.
Participants may have transcranial magnetic stimulation. A wire coil is held on the scalp. A brief electrical current is passed through the coil and creates a magnetic pulse that stimulates the brain. Participants will wear a pair of glasses or a headband with small sensors so researchers can track head position.
Participants will perform a simple index finger movement task.
Participants may have surface electromyography from at least two hand muscles. Small metal disk or adhesive pad electrodes will be taped to the skin. Participants will be seated in a comfortable chair with their hands placed on a pillow.
Participants may have an electroencephalography. A cap with small disc electrodes will be placed on the scalp....
|Condition or disease|
Show Detailed Description
|Study Type :||Observational|
|Estimated Enrollment :||95 participants|
|Official Title:||Detailed Evaluation of the Neurophysiology of Surround Inhibition in the Human Motor Cortex|
|Study Start Date :||January 11, 2017|
|Estimated Primary Completion Date :||December 31, 2020|
|Estimated Study Completion Date :||December 31, 2020|
Healthy volunteers age between 18-70 years
- latency and amplitude of the different components of the TMS-evoked potentials [ Time Frame: throughout protocol ]Sub-study 1: latency and amplitude of the different components of the TMS- evoked potentials.
- Amplitude of the MEP in the EMG signal elicited by single/paired pulse TMS at rest or movement onset will give information about the corticospinal excitability. [ Time Frame: throughout protocol ]Sub-study 2: TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single/paired pulse TMS at rest or movement onset will give information about the corticospinal excitability.
- Amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single pulse TMS at rest or during a motor task will give information about the corticospinal excitability. [ Time Frame: throughout protocol ]Sub-study 3:TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single pulse TMS at rest or during a motor task will give information about the corticospinal excitability.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03018262
|Contact: Elaine P Considine, R.N.||(301) firstname.lastname@example.org|
|United States, Maryland|
|National Institutes of Health Clinical Center||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 email@example.com|
|Principal Investigator:||Mark Hallett, M.D.||National Institute of Neurological Disorders and Stroke (NINDS)|