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Trial record 15 of 658 for:    Sevoflurane

Blood Levels of Sevoflurane and Desflurane

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ClinicalTrials.gov Identifier: NCT03015350
Recruitment Status : Completed
First Posted : January 10, 2017
Last Update Posted : March 5, 2018
Sponsor:
Information provided by (Responsible Party):
ebru biricik, Cukurova University

Brief Summary:
16 patients with American Society of AnesthesioIogy (ASA) physical status I-III will recruited to this study. Patients will divided to the 2 groups. %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D. Each groups will divide 2 subgroups. Two lung ventilation will be performed to Group Sa and Group Da, one lung ventilation will be performed to Group Sb and Group Db. At the time point 40.minutes first blood sample will given from patients. Blood sample will be taken at intervals of 10 minutes from groups of two lung ventilation. In groups of one lung ventilation, blood samples will be taken at the time interval of 10 minutes after one lung ventilation started. All blood samples will be assess in Gas Chromatography.

Condition or disease Intervention/treatment
Anesthetics, Inhalation Drug: Sevoflurane Drug: Desflurane

Detailed Description:

Investigator aimed to assess blood level of sevoflurane and desflurane during two lung ventilation and one lung ventilation. The investigators will use Gas Chromatography for define drugs levels. 16 patients with ASA I-III patients who undergo thoracotomy and abdominal surgery will be recruited to this study. Patients will divided in to the 2 groups. %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D during anesthesia maintenance. Each groups will divide 2 subgroups which are one lung ventilation groups and two lung ventilation groups. Two lung ventilation will be performed to Group Sa and Group Da, one lung ventilation will be performed to Group Sb and Group Db. Sequential blood samples will be taken from both arterial and central venous canula at the same time point. First blood samples will be taken at 40. minutes of anesthesia. Sequential samples will be taken at interval of 10 minutes during two lung ventilation. In one lung ventilation second blood samples will be taken at the 10. minutes of one lung ventilation. After than at the interval of 10 minutes, collection of blood samples both arterial and central venous will be continue.

All collection will assess with gas chromatography.


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Study Type : Observational
Actual Enrollment : 16 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Blood Levels of Sevoflurane and Desflurane During One Lung Ventilation
Study Start Date : December 2016
Actual Primary Completion Date : December 2017
Actual Study Completion Date : December 2017

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
two lung ventilation of Sevoflurane
In GroupSa, 1,5 % sevoflurane will be apply continuously and blood samples will be taken at intervals of 10 minutes starting from the 40th minute.
Drug: Sevoflurane
Measurement of blood desflurane level during one lung ventilation
Other Name: Blood sevoflurane level

one lung ventilation of Sevoflurane
In GroupSa, 1,5 % sevoflurane will be apply continuously and first samples will taken at the 40. minutes and collection of blood samples will be continue at intervals of 10 minutes after one lung ventilation started.
Drug: Sevoflurane
Measurement of blood desflurane level during one lung ventilation
Other Name: Blood sevoflurane level

two lung ventilation of Desflurane
In GroupSa, 6 % desflurane will be apply continuously and blood samples will be taken at intervals of 10 minutes starting from the 40th minute.
Drug: Desflurane
Measurement of blood desflurane level during one lung ventilation
Other Name: Blood desflurane level

one lung ventilation of desflurane
In GroupSa, 6 % desflurane will be apply continuously and first samples will taken at the 40. minutes and collection of blood samples will be continue at intervals of 10 minutes after one lung ventilation started.
Drug: Desflurane
Measurement of blood desflurane level during one lung ventilation
Other Name: Blood desflurane level




Primary Outcome Measures :
  1. Measurement of blood levels of Sevoflurane and Desflurane [ Time Frame: from 40th minute to the end of the operation ]
    Data collections will be ensured from arterial and venous blood sample and than samples will be assessed with gas chromatography and blood sevoflurane and desflurane level will be measured. Blood samples will take every 10 minutes. Only blood levels of sevoflurane and desflurane will be assessed.


Secondary Outcome Measures :
  1. determine of ventilation-perfusion mismatch with p(A-a)O2 [ Time Frame: from 40th minute to the end of the one lung ventilation ]
    During one lung ventilation, p(a-A)O2 will be assessed with arterial blood analyses



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Ages Eligible for Study:   25 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
16 patients with ASA I-III who undergo thoracotomy or abdominal surgery
Criteria

Inclusion Criteria: ASA I-II patients

  • Who undergo thoracotomy or abdominal surgery

Exclusion Criteria:

  • ASA IV and up patients
  • Patients who taken inotropic agent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03015350


Locations
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Turkey
Ebru Biricik
Adana, In The USA Or Canada, Please Select..., Turkey, 01380
Sponsors and Collaborators
Cukurova University
Investigators
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Principal Investigator: Ebru Biricik, MD Cukurova University

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Responsible Party: ebru biricik, MD, Anesthesiology specialist, Cukurova University
ClinicalTrials.gov Identifier: NCT03015350     History of Changes
Other Study ID Numbers: One lung ventilation
First Posted: January 10, 2017    Key Record Dates
Last Update Posted: March 5, 2018
Last Verified: November 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Keywords provided by ebru biricik, Cukurova University:
blood sevoflurane concentration
blood desflurane concentration
one lung ventilation

Additional relevant MeSH terms:
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Sevoflurane
Desflurane
Platelet Aggregation Inhibitors
Anesthetics, Inhalation
Anesthetics, General
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs